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Immune Contributions to Osteoarthritis

  • Osteoimmunology (MB Humphrey and M Nakamura, Section Editors)
  • Published:
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Abstract

Purpose of the Review

Mounting evidence supports a role of low-grade inflammation in the pathophysiology of osteoarthritis (OA). We review and discuss the role of synovitis, complement activation, cytokines, and immune cell population in OA.

Recent Findings

Using newer imaging modalities, synovitis is found in the majority of knees with OA. Complement activation and pro-inflammatory cytokines play a significant role in the development of cartilage destruction and synovitis. Immune cell infiltration of OA synovial tissue by sub-populations of T cells and activated macrophages correlates with OA disease progression and pain.

Summary

The innate and acquired immune system plays a key role in the low-grade inflammation found associated with OA. Targets of these pathways my hold promise for future disease-modifying osteoarthritis drugs (DMOADs).

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Acknowledgements

This study was supported by Presbyterian Health Foundation (MBH) and Veterans Affairs PECASE (MBH).

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Authors and Affiliations

  1. Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA

    Erika Barboza Prado Lopes

  2. Department of Medicine, University of Oklahoma Health Sciences Center, 975 N.E. 10th St, BRC 256, Oklahoma City, OK, 73104, USA

    Adrian Filiberti, Syed Ali Husain & Mary Beth Humphrey

  3. Oklahoma City Veterans Affairs, Oklahoma City, OK, USA

    Mary Beth Humphrey

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  1. Erika Barboza Prado Lopes
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Correspondence to Mary Beth Humphrey.

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Mary Beth Humphrey, Erika Barboza Prado Lopes, Adrian Filiberti, and Syed Ali Husain declare that they have no conflict of interest.

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All report studies with human or animal subjects performed by the authors have been previously published and complied with all applicable ethical standards.

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Lopes, E.B.P., Filiberti, A., Husain, S.A. et al. Immune Contributions to Osteoarthritis. Curr Osteoporos Rep 15, 593–600 (2017). https://doi.org/10.1007/s11914-017-0411-y

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