Abstract
Serum levels of 11-deoxycortisol were determined in 182 hirsute women. Three patients presented high basal 11-deoxycortisol levels and an exaggerated response of this steroid to ACTH stimulation. A fourth patient had normal basal 11-deoxycortisol but was hyperresponsive to ACTH stimulation. Therefore diagnosis of late-onset 11 β-hydroxylase deficiency was made in 4 out of 182 hirsute women with a prevalence of 2.2% in the group studied. In these patients, clinical findings and other hormonal patterns were not different from those of other women suffering from hirsutism.
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Carmina, E., Malizia, G., Pagano, M. et al. Prevalence of late-onset 11 β-hydroxylase-deficiency in hirsute patients. J Endocrinol Invest 11, 595–598 (1988). https://doi.org/10.1007/BF03350188
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DOI: https://doi.org/10.1007/BF03350188