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Effects of sodium-valproate administration on plasma ACTH levels in patients with ACTH hypersecretion

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Abstract

The effects of the acute administration of sodium-valproate (400 mg po) on plasma ACTH levels were studied in 4 patients with Cushing’s disease, 1 with Nelson’s syndrome and in 3 with Addison’s disease. No significant reduction of corticotropin concentration was observed, as compared to saline infusion. These data do not favor the hypothesis of an inhibitory role of sodium-valproate on ACTH secretion in such patients.

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Authors and Affiliations

  1. Clinica Medica II, Padiglione Sacco, Via F. Sforza 35, 20122, Milano, Italy

    B. Ambrosi M.D., D. Bochicchio & E. Riva

  2. Cattedra di Endocrinologia, Università di Milano, Via F. Sforza 35, 20122, Milano, Italy

    G. Faglia

Authors
  1. B. Ambrosi M.D.
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  2. D. Bochicchio
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  3. E. Riva
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  4. G. Faglia
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Ambrosi, B., Bochicchio, D., Riva, E. et al. Effects of sodium-valproate administration on plasma ACTH levels in patients with ACTH hypersecretion. J Endocrinol Invest 6, 305–306 (1983). https://doi.org/10.1007/BF03347595

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  • DOI: https://doi.org/10.1007/BF03347595

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