Abstract
We assessed the changes in cardiac condition in a patient with cardiac amyloidosis, by means of dual nuclei single photon emission computed tomographic (SPECT) images with technetium-99m-hydroxymethylene diphosphonate (99mTc-HMDP) and thallium-201 (201Tl). Dual SPECT showed a marked increase in myocardial99mTc-HMDP accumulation along with deterioration of symptoms and signs, while201Tl scintigraphy remained almost unchanges.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Kyle RA, Greipp PR: Amyloidosis (AL): Clinical and laboratory features in 229 cases.Mayo Clin Proc 58: 665–683, 1983
Siqueira-Filho AG, Cunha CLP, Tajik AJ, et al: M-mode and two-dimensional echocardiographic features in cardiac amyloidosis.Circulation 63: 188–196, 1981
Sivaram CA, Jugdutt BI, Amy RWM, et al: Cardiac amyloidosis: Combined use of two-dimensional echocardiography and electrocardiography in non-invasive screening before biopsy.Clin Cardiol 8: 511–518, 1985
Klein AL, Hatle LK, Taliercio CP, et al: Serial Doppler echocardiographic follow-up of left ventricular diastolic function in cardiac amyloidosis.J Am Coll Cardiol 16: 1135–1141, 1990
Kula RW, Engel WK, Line BR: Scanning for soft-tissue amyloid.Lancet 1: 92–93, 1977
Hongo M, Yamada H, Okubo S, et al: Cardiac involvement in systemic amyloidosis: Myocardial scintigraphic evaluation.J Cardiogr 15: 163–180, 1985 (in Japanese)
Hongo M, Hirayarna J, Fujii T, et al: Early identification of amyloid heart disease by technetium-99m-pyrophosphate scintigraphy: A study with familial amyloid polyneuropathy.Am Heart J 113: 654–662, 1987
Rossello R, Lomena F, Pons F, et al: Bone scan in systemic amyloidosis.Nucl Med Commun 9: 879–890, 1988
Hartmann A, Frenkel J, Hopf R, et al: Is technetium-99m-pyrophosphate scintigraphy valuable in the diagnosis of cardiac amyloidosis ?Int J Card Imag 5 : 227–231, 1990
Willerson JT, Parkey RW, Bonte FJ, et al: Patho-physiologic considerations and clinicopathological correlates of technetium-99m stannous pyrophosphate by myocardial scintigraphy.Semin Nucl Med 10: 54–69, 1980
Bevan JA, Tofe AJ, Benedict JJ, et al: Tc-99m HMDP (Hydroxymethylene Diphosphonate): A radiopharmaceutical for skeletal and acute myocardial infarct imaging. II. Comparison of Tc-99mhydroxymethylene diphosphonate (HMDP) with other technetium-labeled bone-imaging agents in a canine model.J Nucl Med 21: 967–970, 1980
Takezaki M, Ishida Y, Morozurni T, et al: Non-invasive diagnosis of cardiac involvement by technetium-99m-pyrophosphate (Tc-99m PYP) myocardial scintigraphy in 2 cases with familial amyloid polyneuropathy and 1 case with secondary amyloidosis.Kaku Igaku 26:1537–1543, 1989 (in Japanese)
Hongo M, Ikeda S: Echocardiographic assessment of the evolution of amyloid heart disease: A study with familial amyloid polyneuropathy.Circulation 73:249–256, 1986
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kobayashi, T., Sekiya, M., Fujiwara, Y. et al. A patient with cardiac amyloidosis presenting a rapid increase in technetium-99m-hydroxymethylene diphosphonate accumulation. Ann Nucl Med 7, 273–276 (1993). https://doi.org/10.1007/BF03164710
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF03164710