Summary
In summary, it appears from this and other studies that trimetaphan has the potential for producing neuromuscular blockade when used in large doses or when combined with other muscle relaxants. The mode of action appears to be principally that of non-depolarizing neuromuscular blockade. Sodium nitroprusside, on the other hand, even in doses beyond these accepted clinically, does not affect neuromuscular transmission and unless otherwise contraindicated is safe to use with muscle relaxants.
Résumé
Les effets du Nitroprussiate de sodium et ceux du Trimetaphan sur la transmission neuromusculaire ont été étudiés chez la grenouille. Le Nitroprussiate ne modifie pas la transmission neuromusculaire alors que le Trimetaphan a des effets bloqueurs surtout au niveau du récepteur post-synaptique.
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Gergis, S.D., Sokoll, M.D. & Rubbo, J.T. Effect of sodium nitroprusside and trimetaphan on neuromuscular transmission in the frog. Canad. Anaesth. Soc. J. 24, 220–227 (1977). https://doi.org/10.1007/BF03006235
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DOI: https://doi.org/10.1007/BF03006235