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Angiogenesis and organ transplantation

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Abstract

Angiogenesis is a vessel development process that maintains the vascular supply for organ function. Regulation of angiogenesis is provided by positive factors, such as vascular endothelial or basic fibroblast growth factors, and negative factors, such as thrombospondin and macrophage-derived inflammatory cytokines. While the role of angiogenesis in the wound healing, embryogenesis, tumor growth and proliferative diseases is clear, in organ transplantation it is not yet well established. Herein we discuss the potential role of angiogenesis in chronic renal disease and in transplant settings.

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Abbreviations

Ang-1:

angiopoietin 1

Ang-2:

angiopoietin 2

APC:

antigen-presenting cell

bFGF FGF-2:

basic fibroblast growth factor

CD:

cluster of differentiation

Eta-1:

early T-lymphocyte activation-1

HGF/SF:

hepatocyte growth factor/scatter factor

ICAM-1:

intercellular adhesion molecule-1

IL-2:

intrleukin 2

I-R:

ischemia-reperfusion

TGF-β1 :

transforming growth factor β1

TSP-1:

thrombospondine-1

VCAM-1:

vascular cell adhesion molecule-1

VEGF:

vascular endothelial growth factor

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Authors and Affiliations

  1. Department of Nephrology, Transplant Center, Institute for Clinical and Experimental Medicine, 140 21, Prague, Czechia

    J. Rajnoch & O. Viklický

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  1. J. Rajnoch
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  2. O. Viklický
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Correspondence to O. Viklický.

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The study was supported by grants of theCzech Ministry of Health (ND6641/3-2001, CEZ L17/98: 00023001).

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Rajnoch, J., Viklický, O. Angiogenesis and organ transplantation. Folia Microbiol 49, 499–505 (2004). https://doi.org/10.1007/BF02931524

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