Abstract
The present study was undertaken in 100 subjects, 30 diabetics without complication (group I), 40 diabetics with retinopathy (group II) and 30 non diabetic as normal control group (group III). Blood sugar levels, magnesium, cholesterol and triglyceride were analyzed from plasma and serum. The results were correlated with degree of diabetic control from the levels of glycosylated hemoglobin. Serum magnesium levels in group II were found to be significantly lowered than in group I. There was also significant difference in magnesium levels of group I and group III. We found a significant correlation between the glycosylated hemoglobin and magnesium levels in our study.
The results also indicate that the patients with diabetic retinopathy showed significant rise in serum cholesterol and triglyceride. Probably hypomagnesemia and increased serum cholesterol and triglyceride levels are responsible for microvascular changes in diabetes leading to retinopathy. The purpose of this study was thus to gather information about the degree of control of diabetes and magnesium status.
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References
Mather, H.M., Nisbet, J.A., Burton, G.H.,et al. (1979) Hypomagnesemia in diabetes. Clin chem. Acta. 95, 235–242.
Fort, P. and Lifshitz, F. (1986) Magnesium status in children with insulin dependent diabetes mellitus. J. Am. coll. Nutr. 5, 69–78.
Ewald, U., Gebre-Medhin, M. and Turemo, T. (1983) Hypomagnesemia in diabetic children. Acta. Paediatr. Scand. 72, 367–371.
Ceriello, A., Giugliano, D., Dellorurso, P. and Passariello, N. (1982) Hypomag-nesemia in relation to diabetic retinopathy. Diabetic care. 5, 558–559.
Wada, M., Fuji, S., Takemura, T.,et al. (1983) Magnesium levels and diabetic retinopathy. Magnes. Bull. 1, 12–14.
Cahill, G.F., Etzwiler, D.D. and Freinkel N., (1976) Control and Diabetes N. Engl. J. Med. 294, 1004–1005.
Siperstein, M.D., Foster, D.W., Knowles, H.C., Jr., Levine R., Madison L.L. and Roth, J. (1977) Control of blood glucose and diabetic vascular disease. N. Engl. J. Med. 296, 1060–1063.
Peterson, C.M. and Jones, R.L. (1977) Minor hemoglobins, diabetic control and disease of post synthetic modification. Ann. Intern. Med. 87, 489.
Fluckiger, R. and Winter Halter, K.H. (1976) invitro synthesis of HbA1C. REBS lett., 71, 356–360.
Seelig, M.S. and Heggtveit, A. (1974) Magnesium interrelationship in IHD. Am. J. clin. Nutr. 27, 59–79.
Grofton, G. and Borter, M.A. (1992) The role of magnesium in diabetes mellitus. J Diabetes complications. 6, 143–149.
Durlach, J., Altura, B. and Altura, B.M. (1983) Highlights and summary of the 10th Annual French Colloquium on Magnesium. Magnesium. 2, 330–336.
Yajnikcs, C.S., Smith, R.F., Hockaday, T.D.R. and Ward, N.I. (1984) Fasting plasma magnesium concentration and glucose disposal in diabetes. B.M.J. 288, 1032–1034.
McNair, P., Christian, C. and Madsbad, S. (1978) Hypomagnesemia a risk factor in diabetic retinopathy. Diabetes. 27, 1075–1077.
Linderman, R.D., Adler, S., Yeingst, M.J. and Beard, E.S. (1967) Influence of various nutrients on urinary divalent cation excretion. J. Lab. Clin. Med. 70, 236–245.
Lemann, J., Jr. Lemon E.J., Piering, W.R., Prien, E.L., Jr. and Riconoti, E.S. (1970) Evidence that glucose ingestion inhibits net renal tubular reabsorption of calcium and magnesium in man. J. Lab. Clin. Med. 75, 578–585.
Lennon, E.J., Lemann, J., Jr. Prerimg, W.F., and Iarson, L.S. (1974) The effect of glucose on urinary cation excretion during chronic extracellular volume expansion in normal man. J. Clin. Invest. 53, 1424–1433.
Koeing, R.J., Peterson, C.M., Jones, R.L., Saddek, C.et al. (1976). Correlation of glucose regulation and HbA1c in diabetes N. Engl. J. med. 295, 417.
Gonen, B., Rochman, H., Tanega, B.P. and Rubenstein, H. (1977) correlation between HbA1 levels and clinical diabetic control.
Ronal, J., Koeing, Charles M., Peterson, Robert L, Jones, Christopher Saudik, Mark Leherman (1975) Synthesis of hemoglobin A1c in normal and diabetic mice: potential model of basement membrane thickening. Proc. Natl Acad. Sui. USA. 72, 3687–3691.
Boucher, B.J., Welch, S.G. and Beer, M. (1981) Glycosylated haemoglobin in diagnosis of D.M. and for assessment of chronic hyperglycemia. Diabetologia. 21, 34.
Davis, R.E., Nicol, D.J., McCann, V.J.et al. (1978) HbA1 levels in patients with diabetes. Mellitus Med. J. Aust. 1, 530.
Gabby, K.H., Hasta, R., Breslow, J.L., Ellison, R.C., Bunn, H.F. and Gallop, P.M. (1977) Glycosylated Hb and long term glucose control in D.M. J. Clin. Endocrinol. Metabol. 44 (5), 859–864.
Peterson, C.M., Ronald, J., Kowing, B.S.et al. (1977) correlation of serum Triglyceride levels and HbA1c conc. In D.M. Diabetes 26, 507–509 May.
Srivastava, B.N., Mehta, S.G., Pachori, Anita, Bodkhe, R.R. and Gupta, J.C. (1987) Study of HbA1C in IDDM with particular refrence to microangiopathy. J. Diabetic Association. Vol XXVII, Apr.
Rodriguez-Moran, M. and Guerrero-Romero, F. (2003) Oral Magnesium Supplementation Improves Insulin Sensitivity and Metabolic Control in Type-II Diabetic Subject. Diabetes Care. Apr, 26(4), 1147–1152.
Lal, J.et al. (2003) Effect of Oral Magnesium Supplementation on the Lipid profile and Blood Glucose of Patients with Type-II Diabetes Mellitus. J.A.P.I. 51, 37–42.
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Kareem, I., Jaweed, S.A., Bardapurkar, J.S. et al. Study of magnesium, glycosylated hemoglobin and lipid profile in diabetic retinopathy. Indian J Clin Biochem 19, 124–127 (2004). https://doi.org/10.1007/BF02894270
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DOI: https://doi.org/10.1007/BF02894270