Summary
Previous experiments have shown that local irradiation of the carotid arteries of hypercholesterolemic rabbits results in the development of atheromatosis in the irradiated areas of the arteries. The process starts with the adherence of monocytes to the endothelial layer, their entrance into the subendothelial space, and their subsequent transformation into lipophages (foam cells). Prevention of this type of plaque formation can be achieved by prednisolone (in a lower concentration than previously used) (Vos et al. 1981) and by VP16-213 (Vepesid).
Differential blood cell counts demonstrated that the animals subjected to treatment with prednisolone developed a moderate relative lymphocytopenia, whereas treatment with Vepesid resulted in a severe monocytopenia.
Since prednisolone treatment only partially prevented plaque formation, whereas Vepesid seemed to fully inhibit the development of plaques, we conclude that although a role of the lymphocyte in the process of plaque formation cannot be excluded, the monocyte seems to play a crucial role in the pathogenesis of radiation-induced atheromatosis.
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References
Aarnoudse MW (1979) Vessel wall damage by X-rays and 15 MeV neutrons. An experimental study. Thesis, University of Groningen, Groningen, The Netherlands
Gerrity RG (1981) The role of the monocyte in atherogenesis. I. Transition of blood-borne monocytes into foam cells in fatty lesions. Am J Pathol 103:181–190
Gerrity RG, Naito HK, Richardson M, Schwartz CJ (1979) Dietary induced atherogenesis in swine: Morphology of the intima in prelesion stages. Am J Pathol 95:775–786
Hansson GK, Björnheden T, Bylock A, Bondjers G (1981) Fc-dependent binding of monocytes to areas with endothelial injury in the rabbit aorta. Exp Mol Pathol 34:264–280
Parrillo JE, Fauci AS (1979) Mechanisms of glucocorticoid action on immune processes. Ann Rev Pharmacol Toxicol 19:179–201
Smit Sibinga CTh (1973) Prevention of vessel damage in experimental irradiation. Bibl Anat 12:242–248
Thörig L, Thompson J, Eulderink F, Emeis JJ, Van Furth R (1980) Effects of monocytopenia and anticoagulation in experimental streptococcus sanguis endocarditis. Br J Exp Pathol 61:108–116
Vos J, Dijk F, Aarnoudse MW, Lamberts HB (1981) Prevention of radiation-induced atheromatous plaque formation by prednisolone. A morphologic exploration. Cell Biol Int Rep 5:466
Vos J, Aarnoudse MW, Dijk F, Lamberts HB (1983) On the cellular origin and development of atheromatous plaques. A light and electron microscopic study of combined X-ray and hypercholesterolemia-induced atheromatosis in the carotid artery of the rabbit. Virchows Arch [Cell Pathol] 43:1–16
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Aarnoudse, M.W., Lamberts, H.B., Dijk, F. et al. Monocytes and radiation-induced atheromatosis in rabbits. Virchows Archiv B Cell Pathol 47, 211–216 (1984). https://doi.org/10.1007/BF02890204
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DOI: https://doi.org/10.1007/BF02890204