Skip to main content
Log in

The pathogenesis of membranous glomerulonephritis from morphology to molecules

  • Review Article
  • Published:
Virchows Archiv B

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  • Abrass CK (1986) Evaluation of sequential glomerular eluates from rats with Heymann nephritis. J Immunol 137:530–537

    PubMed  CAS  Google Scholar 

  • Abrass CK, Border WA, Glassock RJ (1980) Circulating immune complexes in rat with autologous immune complex nephritis. Lab Invest 42:1–7

    Google Scholar 

  • Adler SG, Wang H, Ward HJ, Cohen AH, Border WA (1983) Electrical charge: Its role in the pathogenesis and prevention of experimental membranous nephropathy in the rabbit. J Clin Invest 71:487–499

    Article  PubMed  CAS  Google Scholar 

  • Adler SP, Baker PJ, Johnson RF, Ochi P, Pritzl P, Couser WG (1986) Complement membrane attack complex stimulates pro-269 duction of reactive oxygen metabolites by cultured rat mesangial cells. J Clin Invest 77:762–774

    Article  PubMed  CAS  Google Scholar 

  • Agodoa LYC, Gauthier VJ, Mannik M (1983) Precipitating antigen-antibody systems are required for the formation of subepithelial electron dense immune deposits in rat glomeruli. J Exp Med 158:1259–1272

    Article  PubMed  CAS  Google Scholar 

  • Allegri L, Brianti E, Chatelet F, Manara GC, Ronco P, Verroust P (1986) Polyvalent antigen-antibody interactions are required for the formation of electron dense immune deposits in passive Heymann nephritis. Am J Pathol 126:1–6

    Google Scholar 

  • Andres G, Brentjens JR, Caldwell PRB, Camussi G, Matuso S (1987) Formation of immune deposits and disease. Lab Invest 55:510–520

    Google Scholar 

  • Assmann KJM, Ronco P, Tangelder MM, Lange WPH, Verroust P, Koene RAP (1985) Comparison of the antigenic targets involved in antibody-mediated glomerulonephritis in the mouse and in the rat. Am J Pathol 121:112–119

    PubMed  CAS  Google Scholar 

  • Bagchus WW, Vos JTWM, Hoedemaeker PhJ, Bakker WW (1986) The specificity of nephritogenic antibodies. III. Binding of anti- F×1A antibodies in glomeruli is dependent on dual specificity. Clin Exp Immunol 63:639–645

    PubMed  CAS  Google Scholar 

  • Barabas AZ, Lannigan R (1974) Induction of an autologous immune-complex glomerulonephritis in the rat by intravenous injection of heterologous anti-rat kidney antibody. I. Production of chronic progressive immune-complex glomerulonephritis. Br J Exp Pathol 55:47–55

    PubMed  CAS  Google Scholar 

  • Bariety J, Druet Ph, Samarq P, Lagrue G (1969) Histogenese des glomerulopathies “extra-membraneuses”. J Urol Nephrol 75:627–640

    CAS  Google Scholar 

  • Bariety JM, Kazatchine MD, Hinglais N, Bhakdi S (1987) Association or independence of the C5b-9 terminal complex of complement and S protein in human diseased kidneys. In: Proceedings of the Xth Int Congress of Nephrology, London, p 372

  • Behar M, Katz A, Silverman M (1986) Biochemical characterization of brush border membrane antigens implicated in the pathogenesis of Heymann nephritis. Kidney Int 30:421–430

    Article  Google Scholar 

  • Behar M, Katz A, Silverman M (1987) A rat cell hybridoma model for study of autologous immune complex nephritis. Kidney Int 31:165a(Abstr)

    Google Scholar 

  • Beregi E, Varga I (1974) Analysis of 260 cases of membranous glomerulonephritis in renal biopsy material. Clin Nephrol 2:213–228

    Google Scholar 

  • Bhan AK, Schneeberger EE, Baird LG, Collins AB, Kamata K, Bradford D, Erikson ME, McCluskey RT (1985) Studies with monoclonal antibodies against brush border antigens in Heymann nephritis. Lab Invest 53:421–432

    PubMed  CAS  Google Scholar 

  • Bisecker G, Noble B, Andres GA, Koffler D (1984) Immunopathogenesis of Heymann’s nephritis. Clin Immunol Immunopathol 33:333–338

    Article  Google Scholar 

  • Bohle A, Buchhorn E, Edel HH, Renner E, Wehner E (1976a) Zur Pathologischen Anatomie der Glomerulonephritiden. In: Sarre H (ed) Nierenkrankheiten, 4th ed. Thieme, Stuttgart, p239

    Google Scholar 

  • Bohle A, Eichenseher N, Fischbach H, Neild GH, Wehner H, Edel HH, Losse H, Renner E, Reichel W, Schuetterle E (1976b) The different forms of glomerulonephritis. Morphological and clinical aspects analyzed in 2500 patients. Klin Wochenschr 54:59–81

    Article  PubMed  CAS  Google Scholar 

  • Border WA, Ward HJ, Kamis ES, Cohen AH (1982) Induction of membranous nephropathy in rabbits by administration of an exogenous cationic antigen: Demonstration of a pathogenic role for electrical charge. J Clin Invest 69:451–461

    Article  PubMed  CAS  Google Scholar 

  • Brada D, Kerjaschki D, Roth J (1990) Cell type specific post-Golgi apparatus localization of a “resident” ER glycoprotein, glucosidase II. J Cell Biol (in press)

  • Brentjens JR, Andres GA (1989) Interaction of antibodies with renal surface antigens. Kidney Int 35:954–968

    Article  PubMed  CAS  Google Scholar 

  • Buc MH, Condamine H, Kerjaschki D (1987) Rat Heymann nephritis antigen is closely related to brushin, a glycoprotein present in early mouse embryo epithelia. Ann Inst Pasteur 138:707–722

    Article  Google Scholar 

  • Cameron JS (1972) The natural history of glomerulonephritis. In: Black DA (ed) Renal Disease, 2nd ed. Blackwell, Oxford, p295

    Google Scholar 

  • Cameron JS (1982) Membranous nephropathy: The treatment dilemma. Am J Kidney Dis 1:371–375

    PubMed  CAS  Google Scholar 

  • Camussi G, Brentjens JR, Noble B, Kerjaschki D, Malavasi F, Roholt OA, Farquhar MG, Andres GA (1985) Antibody-induced redistribution of Heymann antigen on the surface of cultured glomerular visceral epithelial cells: Possible role in the pathogenesis of Heymann glomerulonephritis. J Immunol 135:2409–2416

    PubMed  CAS  Google Scholar 

  • Camussi G, Salvidio G, Biesecker G, Brentjens J, Andres GA (1987) Heymann antibodies induce complement-dependent injury of rat glomerular visceral epithelial cells. J Immunol 139:2906–2918

    PubMed  CAS  Google Scholar 

  • Chatelet F, Brianti E, Ronco P, Roland J, Verroust P (1986a) Ultrastructural localization by monoclonal antibodies of brush border antigens expressed by glomeruli. I. Renal distribution. Am J Pathol 122:500–511

    CAS  Google Scholar 

  • Chatelet F, Brianti E, Ronco P, Roland J, Verroust P (1986b) Ultrastructural localization by monoclonal antibodies of brush border antigens expressed by glomeruli: II. Extrarenal distribution. Am J Pathol 122:512–519

    PubMed  CAS  Google Scholar 

  • Collins AD, Andres GA, McCluskey RT (1981) Lack of evidence for a role of renal tubular antigen in human membranous glomerulonephritis. Nephron 27:297–301

    PubMed  CAS  Google Scholar 

  • Coudrier E, Kerjaschki D, Louvard D (1988) Cytoskeleton organization and submembranous interactions in intestinal and renal brush borders (Editorial Review). Kidney Int 34:309–320

    Article  PubMed  CAS  Google Scholar 

  • Courtoy PJ, Picton DH, Farquhar MG (1983) Resolution and limitations of the immunoperoxidase procedure in the localization of extracellular matrix antigens. J Histochem Cytochem 31:945–952

    PubMed  CAS  Google Scholar 

  • Couser WG (1981) What are circulating immune complexes doing in glomerulonephritis? New Engl J Med 300:1230–1232

    Google Scholar 

  • Couser WG, Baker PJ, Adler S (1984) Complement and the direct mediation of immune glomerular injury: A new perspective (Editorial Review). Kidney Int 28:879–891

    Article  Google Scholar 

  • Couser WG (1985a) Glomerular diseases, Chapter 62. In: Wynngaarden JB, Smith LR (eds) Cecil’s Textbook of Medicine. Philadelphia, Saunders, pp 568–589

    Google Scholar 

  • Couser W (1985b) Mechanisms of glomerular injury in immunecomplex disease. Kidney Int 28:569–583

    Article  PubMed  CAS  Google Scholar 

  • Couser WG, Steinmuller DR, Stilmant MM, Salant DJ, Lowenstein LM (1978) Experimental glomerulonephritis in the isolated perfused rat kidney. J Clin Invest 62:1275–1287

    Article  PubMed  CAS  Google Scholar 

  • Cybulsky AV, Rennke HG, Feintzeig ID, Salant D (1986) Complement induced glomerular epithelial cell injury. Role of the membrane attack complex in rat membranous nephropathy. J Clin Invest 77:1096–1104

    Article  PubMed  CAS  Google Scholar 

  • Dixon FJ, Feldman JD, Vazquez JJ (1961) Experimental glomerulonephritis. The pathogenesis of a laboratory model resembling the spectrum of human glomerulonephritis. J Exp Med 113:899–937

    Article  PubMed  CAS  Google Scholar 

  • Douglas MFS, Rabideau DP, Schwartz MM, Lewis EJ (1981) Evidence on autologous immune complex nephritis. New Engl J Med 305:1326–1329

    PubMed  CAS  Google Scholar 

  • Doxsey SD, Kerjaschki D, Farquhar MG (1983) A large membrane glycoprotein (gp330) is a resident of coated pits of several absorptive epithelia. J Cell Biol 97:178a (Abstr)

    Article  Google Scholar 

  • Edgington TS, Glassock RJ, Dixon FJ (1967) Autologous immune complex pathogenesis of experimental allergic glomerulonephritis. Science 155:1432–1434

    Article  PubMed  CAS  Google Scholar 

  • Edgington TS, Glassock RJ, Dixon FJ (1968) Autologous immune complex nephritis induced with renal tubular antigen. I. Identification and isolation of the pathogenic antigen. J Exp Med 127:555–572

    Article  PubMed  CAS  Google Scholar 

  • Ehrenreich T, Churg J (1968) Pathology of membranous nephropathy. Pathol Annu 3:145–186

    Google Scholar 

  • Erwin DT, Donadio JV, Holley KE (1973) The clinical course of idipathic membranous nephropathy. Mayo Clin Proc 48:697–701

    PubMed  CAS  Google Scholar 

  • Falk RJ, Podack E, Dalmasso AP, Jennette JC (1987) Localization of S Protein and its relationship to the membrane attack complex of complement in renal tissue. Am J Pathol 127:182–190

    PubMed  CAS  Google Scholar 

  • Fleuren GJ, Grond J, Hoedemaeker PhJ (1980) The pathogenic role of free-circulating antibody in autologous immune complex glomerulonephritis. Clin Exp Immunol 41:205–217

    PubMed  CAS  Google Scholar 

  • Germuth FG, Rodriguez E (1973) Immunopathology of the renal glomerulus. In: Immune complex deposition and anti-basement membrane disease. Little Brown, Boston

    Google Scholar 

  • Goldstein JL, Anderson RGW, Brown MS (1979) Coated pits, coated vesicles, and receptor mediated endocytosis. Nature 279:679–683

    Article  PubMed  CAS  Google Scholar 

  • Goodyear PR, Mills M, Kaplan BS (1985) Analysis of the Heymann nephritogenic glycoprotein in rat, mouse and human kidney. Biochem Cell Biol 64:441–449

    Article  Google Scholar 

  • Grupe WE, Kaplan MH (1969) Demonstration of an antibody to proximal tubular antigen in the pathogenesis of experimental autoimmune nephrosis in rats. J Lab Clin Med 74:400–409

    PubMed  CAS  Google Scholar 

  • Habib R, Kleinknecht C (1973) Idiopathic extramembranous glomerulonephritis in children. In: Kincaid-Smith P, Mathew TH, Becker EL (eds) Glomerulonephritis, morphology, natural history and treatment, part I. Wiley, New York, p 449

    Google Scholar 

  • Heptinstall RH (1974) Pathology of the kidney, 2nd ed. Little, Brown and Co, Boston

    Google Scholar 

  • Heymann W, Hackel DB, Harwood S, Wilson SGF, Hunter JLP (1959) Production of nephrotic syndrome in rats by Freunds adjuvants and rat kidney suspensions. Proc Soc Exp Biol Med 100:660–664

    PubMed  CAS  Google Scholar 

  • Heymann W, Knutec EP, Wilson SGF, Hunter JLP, Hackel DB, Okuda R, Cuppage L (1965) Experimental autoimmune renal disease in rats. Ann NY Acad Sci 124:310–326

    Article  PubMed  CAS  Google Scholar 

  • Hinglais N, Kazatchine MD, Bhakdi S, Appay MD, Mandet C, Grossette J, Bariety J (1986) Immunohistochemical study of the C5b-9 complex of complement in normal kidneys. Kidney Int 30:399–412

    Article  PubMed  CAS  Google Scholar 

  • Hoedemaeker PhJ, Weening JJ (1989) Relevance of experimental models for human nephropathy. Kidney Int 1015–1025

  • Hogendoorn PCW, Bruijn JA, van der Broek LJCM, DeHeer E, Foidart JM, Hoedemaeker PhJ, Fleuren GJ (1988) Antibodies to purified renal tubular epithelial antigens contain activity against laminin, fibronectin and type IV collagen. Lab Invest 58:278–286

    PubMed  CAS  Google Scholar 

  • Jenne D, Stanley KK (1985) Molecular cloning of S-protein, a link between complement, coagulation and cell-substrate adhesion. EMBO J 4:3153–3157

    PubMed  CAS  Google Scholar 

  • Jeraj K, Vernier RL, Sisson SP, Michael MF (1984) A new glomerular antigen in passive Heymann’s nephritis. Br J Exp Pathol 65:485–498

    PubMed  CAS  Google Scholar 

  • Kamata K, Baird LG, Erikson ME, Collins AB, McCluskey RT (1986) Characterization of antigen and antibody specificities involved in Heymann nephritis. J Immunol 135:2400–2412

    Google Scholar 

  • Kanalas JJ, Makker SP (1988) A possible ligand of serum origin for the kidney autoantigen of Heymann nephritis. J Immunol 141:4152–4157

    PubMed  CAS  Google Scholar 

  • Kerjaschki D, Farquhar MG (1982) The pathogenic antigen of Heymann nephritis is a glycoprotein of the renal proximal tubule brush border. Proc Natl Acad Sci USA 79:5557–5561

    Article  PubMed  CAS  Google Scholar 

  • Kerjaschki D, Farquhar MG (1983) Immunocytochemical localization of the Heymann nephritis antigen (gp330) in glomerular epithelial cells of normal Lewis rats. J Exp Med 157:667–686

    Article  PubMed  CAS  Google Scholar 

  • Kerjaschki D, Farquhar MG (1985) Pathogenic antigen of Heymann nephritis (gp330): Identification, Isolation, and Localization. In: Robinson RR (ed) Nephrology, vol 1. Springer, Berlin Heidelberg New York, pp 560–574

    Google Scholar 

  • Kerjaschki D, Noronha-Blob L, Sacktor B, Farquhar MG (1984) Microdomains of distinctive glycoprotein composition in the kidney proximal tubule brush borders. J Cell Biol 98:1505–1513

    Article  PubMed  CAS  Google Scholar 

  • Kerjaschki D, Sawada H, Farquhar MG (1986) Immunoelectron microscopy in kidney research: Some contributions and limitations. Kidney Int 30:229–245

    Article  PubMed  CAS  Google Scholar 

  • Kerjaschki D, Miettinnen A, Farquhar MG (1987a) Initial events in the formation of immune deposits in passive Heymann nephritis J Exp Med 166:109–128

    Article  PubMed  CAS  Google Scholar 

  • Kerjaschki D, Horvat R, Binder S, Susani M, Dekan G, Ojha PP, Hillemanns P, Ulrich W, Donini U (1987 b) Identification of a 400-kD protein in the brush borders of human kidney tubules that is similar to gp330, the nephritogenic antigen of rat Heymann nephritis. Am J Pathol 129:183–191

    PubMed  CAS  Google Scholar 

  • Kerjaschki D, Schulze M, Binder S, Kain R, Ojha PP, Susani M, Horvat R, Baker P, Couser WG (1989) Transcellular transport and membrane insertion of the C5b-9 membrane attack complex of complement by glomerular epithelial cells in experimental membranous nephropathy. J Immunol 143:546–552

    PubMed  CAS  Google Scholar 

  • Leung CCK (1982) Isolation, partial characterization and localization of a rat renal tubular glycoprotein. Antibody-induced birth defects. J Exp Med 156:372–384

    Article  PubMed  CAS  Google Scholar 

  • Madaio MP, Salant DJ, Cohen AJ, Adler S, Couser WG (1983) Comparative study of in situ immune deposit formation in active and passive Heymann nephritis. Kidney Int 23:498–505

    Article  PubMed  CAS  Google Scholar 

  • Makker SP, Singh AK (1984) Characterization of the antigen (gp600) of Heymann nephritis. Lab Invest 50:287–293

    PubMed  CAS  Google Scholar 

  • Mannik M, Agodoa LYC, David KA (1983) Rearrangement of immune complexes in glomeruli leads to persistence and development of electron dense deposits. J Exp Med 157:1516–1528

    Article  PubMed  CAS  Google Scholar 

  • Miettinen A, Törnroth T, Tikkanen I, Virtanen I, Linder E (1980) Heymann nephritis induced by kidney brush border glycoproteins. Lab Invest 43:547–555

    PubMed  CAS  Google Scholar 

  • Miettinen A, Törnroth T, Vartio T (1984) Expression of three brush border membrane polypeptides of high molecular weight in rat kidney and other epithelia. J Cell Biol 99:106a (Abstr)

    Google Scholar 

  • Morgan P, Dambert JR, Esser A (1987) Recovery of human neutrophils from complement attack. Removal of the membrane attack complex by endocytosis and exocytosis. J Immunol 138:246–253

    PubMed  CAS  Google Scholar 

  • Naruse T, Kitamura D, Miyakawa Y, Shibata S (1973) Deposition of renal tubular epithelial antigens along the renal glomerular capillary walls of patients with membranous glomerulonephritis. J Immunol 110:1163–1169

    Google Scholar 

  • Naruse T, Fukasawa T, Miyakawa Y (1975) Laboratory model of membranous glomerulonephritis in rats induced by pronasedigested homologous renal tubular epithelial antigen. Lab Invest 33:141–152

    PubMed  CAS  Google Scholar 

  • Naruse T, Fukasawa T, Umegae S, Oite S, Miyakawa Y (1978) Experimental membranous glomerulonephritis in rats: Correlation of ultrastructural changes with the serum level of autologous antibody against tubular antigen. Lab Invest 39:120–134

    PubMed  CAS  Google Scholar 

  • Natori Y, Hyakawa I, Shibata S (1986) Passive Heymann nephritis with acute and severe proteinuria induced by heterologous antibody against renal tubular brush border glycoprotein gp108. Lab Invest 55:63–70

    PubMed  CAS  Google Scholar 

  • Natori Y, Hayakawa I, Shibata S (1987a) Identification of gpl08, a pathogenic antigen of passive Heymann nephritis, as dipeptidyl peptidase IV. Clin Exp Immunol 70:434–439

    PubMed  CAS  Google Scholar 

  • Natori Y, Hayakawa I, Shibata S (1987b) Heymann nephritis in rats induced by human renal tubular antigens: Characterization of antigen and antibody specificities. Clin Exp Immunol 69:33–40

    PubMed  CAS  Google Scholar 

  • Natori Y, Hayakawa I, Shibata S (1989) Role of dipeptidyl peptidase IV (gpl08) in passive Heymann nephritis. Am J Pathol 134:405–410

    CAS  Google Scholar 

  • Neale TJ, Wilson CB (1982) Glomerular antigens in Heymann nephritis: Reactivity of eluted and circulating antibody. J Immunol 128:323–330

    PubMed  CAS  Google Scholar 

  • Neale TJ, Couser WG, Salant DJ, Lowenstein LM, Wilson CB (1982) Specific uptake of Heymann’s nephritic kidney eluate by rat kidney. Lab Invest 46:450–453

    PubMed  CAS  Google Scholar 

  • Niles J, Collins B, Baird L, Erikson M, Bradford D, Pan G, Hsiung CK, Schneeberger EE, Bhan A, McCluskey RT (1987) Antibodies reactive with a renal glycoprotein and deposits in membranous nephritis (Abstr). Kidney Int 31:338

    Google Scholar 

  • Oite TM, Batsford SR, Mihatsch M, Takamiya H, Vogt A (1982) Quantitative studies of the in situ immune complex glomerulonephritis in the rat induced by planted cationized antigen. J Exp Med 155:460–474

    Article  PubMed  CAS  Google Scholar 

  • Ozawa M, Yonezawa S, Sato E, Muramatsu T (1982) A new glycoprotein antigen common to teratocarcinoma, visceral endoderm and renal tubular brush border. Dev Biol 91:351–359

    Article  PubMed  CAS  Google Scholar 

  • Perkinson DT, Baker PJ, Couser WG, Johnson R, Adler S (1985) Membrane attack complex deposition in experimental glomerular injury. Am J Pathol 120:121–136

    PubMed  CAS  Google Scholar 

  • Podack ER, Müller-Eberhard HJ (1979) Isolation of human Sprotein, an inhibitor of the membrane attack complex of complement. J Biol Chem 254:9908–9914

    Google Scholar 

  • Ponticelli C (1986) Prognosis and treatment of membranous nephropathy. Kidney Int 29:927–940

    Article  PubMed  CAS  Google Scholar 

  • Pruchno CJ, Burns MW, Schulze M, Johnson RJ, Baker PJ, Couser WG (1989) Urinary excretion of C5b-9 reflects disease activity in passive Heymann nephritis. Kidney Int 36:65–71

    Article  PubMed  CAS  Google Scholar 

  • Quigg RJ, Cybulsky AV, Jacobs JB, Salant DJ (1988) Anti-F×1A produces complement dependent cytotoxicity in glomerular epithelial cells. Kidney Int 34:43–61

    Article  PubMed  CAS  Google Scholar 

  • Rastogy SD, Hart-Mercer J, Kerr DNS (1968) Idiopathic membranous glomerulonephritis in adults: remission following steroid therapy. QJ Med 38:335–349

    Google Scholar 

  • Raychowdhury R, Niles J, McCluskey RT, Smith JA (1989) Autoimmune target in Heymann nephritis is a glycoprotein with homology to the LDL receptor. Science 244:1163–1165

    Article  PubMed  CAS  Google Scholar 

  • Rodman JSD, Kerjaschki D, Merisko EC, Farquhar MG (1984) Presence of an extensive clathrin coat on the apical plasmalemma of the rat kidney proximal tubule cell. J Cell Biol 98:1630–1636

    Article  PubMed  CAS  Google Scholar 

  • Ronco P, Melcion C, Geniteau E, Ronco L, Reininger P, Galceran P, Verroust P (1984a) Production and characterization of monoclonal antibodies against rat brush border antigens of the proximal convoluted tubule. Immunology 53:78–95

    Google Scholar 

  • Ronco P, Allegri L, Melcion C, Pirotsky E, Appay MD, Bariety J, Pontillon F, Verroust P (1984b) A monoclonal antibody to brush borders and passive Heymann nephritis. Clin Exp Immunol 55:319–332

    PubMed  CAS  Google Scholar 

  • Ronco P, Neale TJ, Wilson CB, Galceran M, Verroust P (1986) An immunopathological study of a 330 kD protein defined by monoclonal antibodies and reactive with anti-RTEa5 antibodies and kidney eluates from active Heymann nephritis. J Immunol 136:125–130

    PubMed  CAS  Google Scholar 

  • Ronco P, Van Leer EHG, Chatelet F, Tauc M, Verroust P (1987) Brush border hydrolases expressed by glomerular epithelial cells are target antigens for the formation of immune deposits. Kidney Int 31:329a (Abstr)

    Google Scholar 

  • Rosen S (1971) Membranous glomerulonephritis: Current status. Human Pathol 2:209–241

    Article  CAS  Google Scholar 

  • Sahali D, Mulliez N, Chatelet F, Dupuis R, Ronco P, Verroust P (1988) Characterization of a 280 kD protein restricted to the coated pits of the renal brush border and the epithelial cells of the yolk sac: Teratogenic effect of the specific monoclonal antibodies. J Exp Med 167:213–218

    Article  PubMed  CAS  Google Scholar 

  • Salant D, Belok S, Madaio MP, Couser WG (1980) A new role for complement in experimental membranous nephropathy in rats. J Clin Invest 66:1339–1351

    Article  PubMed  CAS  Google Scholar 

  • Schulze M, Baker PJ, Perkinson DT, Johnson RJ, Ochi RF, Stahl RAK, Couser WG (1989) Increased urinary excretion of C5b-9 distinguishes passive Heymann nephritis from other forms of experimental glomerulonephritis in the rat. Kidney Int 35:60–78

    Article  PubMed  CAS  Google Scholar 

  • Sugisaki TJ, Klassen J, Andres GA, Milgrom FJ, McCluskey RT (1973) Passive transfer of Heymann’s nephritis with serum. Kidney Int 3:66–73

    Article  PubMed  CAS  Google Scholar 

  • Thoenes W (1973) Pathohistologische Systematik der Glomerulonephritis — unter Berücksichtigung klinischer Aspekte. Nieren- und Hochdruckkrank 5:199–207

    Google Scholar 

  • Thoenes G, Pielsticker K, Schubert G (1979) Transplantation-induced immune complex disease in rats with unilateral manifestation in the allografted kidney. Lab Invest 41:321–333

    PubMed  CAS  Google Scholar 

  • VanDamme BJC, Fleuren GJ, Bakker WW, Vernier RL, Hoedemaeker PhJ (1978) Experimental glomerulonephritis in the rat induced by antibodies directed against tubular antigens. V. Fixed glomerular antigens in the pathogenesis of heterologous immune complex nephritis. Lab Invest 38:502–510

    PubMed  Google Scholar 

  • Verroust P (1989) Nephrology Forum: Kinetics of immune deposits in membranous nephropathy. Kidney Int 1418–1428

  • Vogt A (1984) New aspects of the pathogenesis of immune complex glomerulonephritis: Formation of subepithelial deposits. Clin Nephrol 21:15–20

    PubMed  CAS  Google Scholar 

  • Whitworth J, Liebowitz S, Kennedy M, Cameron J, Evans D, Glassock R, Schoenfeld L (1976) Absence of glomerular renal epithelial antigen in membranous glomerulonephritis. Clin Nephrol 5:159–167

    PubMed  CAS  Google Scholar 

  • Zager RA, Couser WG, Andrews BS, Bolton WK, Pohl MA (1979) Radioimmunologic search for anti-tubular epithelial antibodies and circulating immune complexes in patients with membranous nephropathy. Nephron 24:10–16

    Article  PubMed  CAS  Google Scholar 

  • Zanetti M, Mandet C, Duboust A, Bedrosiian J, Bariety J (1981) Demonstration of a passive Heymann-nephritis like mechanism in human kidney transplants. Clin Nephrol 15:272–288

    PubMed  CAS  Google Scholar 

  • Zollinger HU, Mihatsch JM (1978) Renal pathology in biopsy. Springer, Berlin Heidelberg New York, pp 261–278

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

Supported by the Fonds zu Förderung der Wissenschaftlichen Forschung, Projekt No. P7712Med

Synonyms: Epimembranous glomerulonephritis; membranous glomerulopathy; extramembranous glomerulonephritis; transmembranous glomerulopathy; type II-nephritis (Ellis)

Prof. H.V. Zollinger in memoriam

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kerjaschki, D. The pathogenesis of membranous glomerulonephritis from morphology to molecules. Virchows Archiv B Cell Pathol 58, 253–271 (1989). https://doi.org/10.1007/BF02890080

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02890080

Keywords

Navigation