References
Abrass CK (1986) Evaluation of sequential glomerular eluates from rats with Heymann nephritis. J Immunol 137:530–537
Abrass CK, Border WA, Glassock RJ (1980) Circulating immune complexes in rat with autologous immune complex nephritis. Lab Invest 42:1–7
Adler SG, Wang H, Ward HJ, Cohen AH, Border WA (1983) Electrical charge: Its role in the pathogenesis and prevention of experimental membranous nephropathy in the rabbit. J Clin Invest 71:487–499
Adler SP, Baker PJ, Johnson RF, Ochi P, Pritzl P, Couser WG (1986) Complement membrane attack complex stimulates pro-269 duction of reactive oxygen metabolites by cultured rat mesangial cells. J Clin Invest 77:762–774
Agodoa LYC, Gauthier VJ, Mannik M (1983) Precipitating antigen-antibody systems are required for the formation of subepithelial electron dense immune deposits in rat glomeruli. J Exp Med 158:1259–1272
Allegri L, Brianti E, Chatelet F, Manara GC, Ronco P, Verroust P (1986) Polyvalent antigen-antibody interactions are required for the formation of electron dense immune deposits in passive Heymann nephritis. Am J Pathol 126:1–6
Andres G, Brentjens JR, Caldwell PRB, Camussi G, Matuso S (1987) Formation of immune deposits and disease. Lab Invest 55:510–520
Assmann KJM, Ronco P, Tangelder MM, Lange WPH, Verroust P, Koene RAP (1985) Comparison of the antigenic targets involved in antibody-mediated glomerulonephritis in the mouse and in the rat. Am J Pathol 121:112–119
Bagchus WW, Vos JTWM, Hoedemaeker PhJ, Bakker WW (1986) The specificity of nephritogenic antibodies. III. Binding of anti- F×1A antibodies in glomeruli is dependent on dual specificity. Clin Exp Immunol 63:639–645
Barabas AZ, Lannigan R (1974) Induction of an autologous immune-complex glomerulonephritis in the rat by intravenous injection of heterologous anti-rat kidney antibody. I. Production of chronic progressive immune-complex glomerulonephritis. Br J Exp Pathol 55:47–55
Bariety J, Druet Ph, Samarq P, Lagrue G (1969) Histogenese des glomerulopathies “extra-membraneuses”. J Urol Nephrol 75:627–640
Bariety JM, Kazatchine MD, Hinglais N, Bhakdi S (1987) Association or independence of the C5b-9 terminal complex of complement and S protein in human diseased kidneys. In: Proceedings of the Xth Int Congress of Nephrology, London, p 372
Behar M, Katz A, Silverman M (1986) Biochemical characterization of brush border membrane antigens implicated in the pathogenesis of Heymann nephritis. Kidney Int 30:421–430
Behar M, Katz A, Silverman M (1987) A rat cell hybridoma model for study of autologous immune complex nephritis. Kidney Int 31:165a(Abstr)
Beregi E, Varga I (1974) Analysis of 260 cases of membranous glomerulonephritis in renal biopsy material. Clin Nephrol 2:213–228
Bhan AK, Schneeberger EE, Baird LG, Collins AB, Kamata K, Bradford D, Erikson ME, McCluskey RT (1985) Studies with monoclonal antibodies against brush border antigens in Heymann nephritis. Lab Invest 53:421–432
Bisecker G, Noble B, Andres GA, Koffler D (1984) Immunopathogenesis of Heymann’s nephritis. Clin Immunol Immunopathol 33:333–338
Bohle A, Buchhorn E, Edel HH, Renner E, Wehner E (1976a) Zur Pathologischen Anatomie der Glomerulonephritiden. In: Sarre H (ed) Nierenkrankheiten, 4th ed. Thieme, Stuttgart, p239
Bohle A, Eichenseher N, Fischbach H, Neild GH, Wehner H, Edel HH, Losse H, Renner E, Reichel W, Schuetterle E (1976b) The different forms of glomerulonephritis. Morphological and clinical aspects analyzed in 2500 patients. Klin Wochenschr 54:59–81
Border WA, Ward HJ, Kamis ES, Cohen AH (1982) Induction of membranous nephropathy in rabbits by administration of an exogenous cationic antigen: Demonstration of a pathogenic role for electrical charge. J Clin Invest 69:451–461
Brada D, Kerjaschki D, Roth J (1990) Cell type specific post-Golgi apparatus localization of a “resident” ER glycoprotein, glucosidase II. J Cell Biol (in press)
Brentjens JR, Andres GA (1989) Interaction of antibodies with renal surface antigens. Kidney Int 35:954–968
Buc MH, Condamine H, Kerjaschki D (1987) Rat Heymann nephritis antigen is closely related to brushin, a glycoprotein present in early mouse embryo epithelia. Ann Inst Pasteur 138:707–722
Cameron JS (1972) The natural history of glomerulonephritis. In: Black DA (ed) Renal Disease, 2nd ed. Blackwell, Oxford, p295
Cameron JS (1982) Membranous nephropathy: The treatment dilemma. Am J Kidney Dis 1:371–375
Camussi G, Brentjens JR, Noble B, Kerjaschki D, Malavasi F, Roholt OA, Farquhar MG, Andres GA (1985) Antibody-induced redistribution of Heymann antigen on the surface of cultured glomerular visceral epithelial cells: Possible role in the pathogenesis of Heymann glomerulonephritis. J Immunol 135:2409–2416
Camussi G, Salvidio G, Biesecker G, Brentjens J, Andres GA (1987) Heymann antibodies induce complement-dependent injury of rat glomerular visceral epithelial cells. J Immunol 139:2906–2918
Chatelet F, Brianti E, Ronco P, Roland J, Verroust P (1986a) Ultrastructural localization by monoclonal antibodies of brush border antigens expressed by glomeruli. I. Renal distribution. Am J Pathol 122:500–511
Chatelet F, Brianti E, Ronco P, Roland J, Verroust P (1986b) Ultrastructural localization by monoclonal antibodies of brush border antigens expressed by glomeruli: II. Extrarenal distribution. Am J Pathol 122:512–519
Collins AD, Andres GA, McCluskey RT (1981) Lack of evidence for a role of renal tubular antigen in human membranous glomerulonephritis. Nephron 27:297–301
Coudrier E, Kerjaschki D, Louvard D (1988) Cytoskeleton organization and submembranous interactions in intestinal and renal brush borders (Editorial Review). Kidney Int 34:309–320
Courtoy PJ, Picton DH, Farquhar MG (1983) Resolution and limitations of the immunoperoxidase procedure in the localization of extracellular matrix antigens. J Histochem Cytochem 31:945–952
Couser WG (1981) What are circulating immune complexes doing in glomerulonephritis? New Engl J Med 300:1230–1232
Couser WG, Baker PJ, Adler S (1984) Complement and the direct mediation of immune glomerular injury: A new perspective (Editorial Review). Kidney Int 28:879–891
Couser WG (1985a) Glomerular diseases, Chapter 62. In: Wynngaarden JB, Smith LR (eds) Cecil’s Textbook of Medicine. Philadelphia, Saunders, pp 568–589
Couser W (1985b) Mechanisms of glomerular injury in immunecomplex disease. Kidney Int 28:569–583
Couser WG, Steinmuller DR, Stilmant MM, Salant DJ, Lowenstein LM (1978) Experimental glomerulonephritis in the isolated perfused rat kidney. J Clin Invest 62:1275–1287
Cybulsky AV, Rennke HG, Feintzeig ID, Salant D (1986) Complement induced glomerular epithelial cell injury. Role of the membrane attack complex in rat membranous nephropathy. J Clin Invest 77:1096–1104
Dixon FJ, Feldman JD, Vazquez JJ (1961) Experimental glomerulonephritis. The pathogenesis of a laboratory model resembling the spectrum of human glomerulonephritis. J Exp Med 113:899–937
Douglas MFS, Rabideau DP, Schwartz MM, Lewis EJ (1981) Evidence on autologous immune complex nephritis. New Engl J Med 305:1326–1329
Doxsey SD, Kerjaschki D, Farquhar MG (1983) A large membrane glycoprotein (gp330) is a resident of coated pits of several absorptive epithelia. J Cell Biol 97:178a (Abstr)
Edgington TS, Glassock RJ, Dixon FJ (1967) Autologous immune complex pathogenesis of experimental allergic glomerulonephritis. Science 155:1432–1434
Edgington TS, Glassock RJ, Dixon FJ (1968) Autologous immune complex nephritis induced with renal tubular antigen. I. Identification and isolation of the pathogenic antigen. J Exp Med 127:555–572
Ehrenreich T, Churg J (1968) Pathology of membranous nephropathy. Pathol Annu 3:145–186
Erwin DT, Donadio JV, Holley KE (1973) The clinical course of idipathic membranous nephropathy. Mayo Clin Proc 48:697–701
Falk RJ, Podack E, Dalmasso AP, Jennette JC (1987) Localization of S Protein and its relationship to the membrane attack complex of complement in renal tissue. Am J Pathol 127:182–190
Fleuren GJ, Grond J, Hoedemaeker PhJ (1980) The pathogenic role of free-circulating antibody in autologous immune complex glomerulonephritis. Clin Exp Immunol 41:205–217
Germuth FG, Rodriguez E (1973) Immunopathology of the renal glomerulus. In: Immune complex deposition and anti-basement membrane disease. Little Brown, Boston
Goldstein JL, Anderson RGW, Brown MS (1979) Coated pits, coated vesicles, and receptor mediated endocytosis. Nature 279:679–683
Goodyear PR, Mills M, Kaplan BS (1985) Analysis of the Heymann nephritogenic glycoprotein in rat, mouse and human kidney. Biochem Cell Biol 64:441–449
Grupe WE, Kaplan MH (1969) Demonstration of an antibody to proximal tubular antigen in the pathogenesis of experimental autoimmune nephrosis in rats. J Lab Clin Med 74:400–409
Habib R, Kleinknecht C (1973) Idiopathic extramembranous glomerulonephritis in children. In: Kincaid-Smith P, Mathew TH, Becker EL (eds) Glomerulonephritis, morphology, natural history and treatment, part I. Wiley, New York, p 449
Heptinstall RH (1974) Pathology of the kidney, 2nd ed. Little, Brown and Co, Boston
Heymann W, Hackel DB, Harwood S, Wilson SGF, Hunter JLP (1959) Production of nephrotic syndrome in rats by Freunds adjuvants and rat kidney suspensions. Proc Soc Exp Biol Med 100:660–664
Heymann W, Knutec EP, Wilson SGF, Hunter JLP, Hackel DB, Okuda R, Cuppage L (1965) Experimental autoimmune renal disease in rats. Ann NY Acad Sci 124:310–326
Hinglais N, Kazatchine MD, Bhakdi S, Appay MD, Mandet C, Grossette J, Bariety J (1986) Immunohistochemical study of the C5b-9 complex of complement in normal kidneys. Kidney Int 30:399–412
Hoedemaeker PhJ, Weening JJ (1989) Relevance of experimental models for human nephropathy. Kidney Int 1015–1025
Hogendoorn PCW, Bruijn JA, van der Broek LJCM, DeHeer E, Foidart JM, Hoedemaeker PhJ, Fleuren GJ (1988) Antibodies to purified renal tubular epithelial antigens contain activity against laminin, fibronectin and type IV collagen. Lab Invest 58:278–286
Jenne D, Stanley KK (1985) Molecular cloning of S-protein, a link between complement, coagulation and cell-substrate adhesion. EMBO J 4:3153–3157
Jeraj K, Vernier RL, Sisson SP, Michael MF (1984) A new glomerular antigen in passive Heymann’s nephritis. Br J Exp Pathol 65:485–498
Kamata K, Baird LG, Erikson ME, Collins AB, McCluskey RT (1986) Characterization of antigen and antibody specificities involved in Heymann nephritis. J Immunol 135:2400–2412
Kanalas JJ, Makker SP (1988) A possible ligand of serum origin for the kidney autoantigen of Heymann nephritis. J Immunol 141:4152–4157
Kerjaschki D, Farquhar MG (1982) The pathogenic antigen of Heymann nephritis is a glycoprotein of the renal proximal tubule brush border. Proc Natl Acad Sci USA 79:5557–5561
Kerjaschki D, Farquhar MG (1983) Immunocytochemical localization of the Heymann nephritis antigen (gp330) in glomerular epithelial cells of normal Lewis rats. J Exp Med 157:667–686
Kerjaschki D, Farquhar MG (1985) Pathogenic antigen of Heymann nephritis (gp330): Identification, Isolation, and Localization. In: Robinson RR (ed) Nephrology, vol 1. Springer, Berlin Heidelberg New York, pp 560–574
Kerjaschki D, Noronha-Blob L, Sacktor B, Farquhar MG (1984) Microdomains of distinctive glycoprotein composition in the kidney proximal tubule brush borders. J Cell Biol 98:1505–1513
Kerjaschki D, Sawada H, Farquhar MG (1986) Immunoelectron microscopy in kidney research: Some contributions and limitations. Kidney Int 30:229–245
Kerjaschki D, Miettinnen A, Farquhar MG (1987a) Initial events in the formation of immune deposits in passive Heymann nephritis J Exp Med 166:109–128
Kerjaschki D, Horvat R, Binder S, Susani M, Dekan G, Ojha PP, Hillemanns P, Ulrich W, Donini U (1987 b) Identification of a 400-kD protein in the brush borders of human kidney tubules that is similar to gp330, the nephritogenic antigen of rat Heymann nephritis. Am J Pathol 129:183–191
Kerjaschki D, Schulze M, Binder S, Kain R, Ojha PP, Susani M, Horvat R, Baker P, Couser WG (1989) Transcellular transport and membrane insertion of the C5b-9 membrane attack complex of complement by glomerular epithelial cells in experimental membranous nephropathy. J Immunol 143:546–552
Leung CCK (1982) Isolation, partial characterization and localization of a rat renal tubular glycoprotein. Antibody-induced birth defects. J Exp Med 156:372–384
Madaio MP, Salant DJ, Cohen AJ, Adler S, Couser WG (1983) Comparative study of in situ immune deposit formation in active and passive Heymann nephritis. Kidney Int 23:498–505
Makker SP, Singh AK (1984) Characterization of the antigen (gp600) of Heymann nephritis. Lab Invest 50:287–293
Mannik M, Agodoa LYC, David KA (1983) Rearrangement of immune complexes in glomeruli leads to persistence and development of electron dense deposits. J Exp Med 157:1516–1528
Miettinen A, Törnroth T, Tikkanen I, Virtanen I, Linder E (1980) Heymann nephritis induced by kidney brush border glycoproteins. Lab Invest 43:547–555
Miettinen A, Törnroth T, Vartio T (1984) Expression of three brush border membrane polypeptides of high molecular weight in rat kidney and other epithelia. J Cell Biol 99:106a (Abstr)
Morgan P, Dambert JR, Esser A (1987) Recovery of human neutrophils from complement attack. Removal of the membrane attack complex by endocytosis and exocytosis. J Immunol 138:246–253
Naruse T, Kitamura D, Miyakawa Y, Shibata S (1973) Deposition of renal tubular epithelial antigens along the renal glomerular capillary walls of patients with membranous glomerulonephritis. J Immunol 110:1163–1169
Naruse T, Fukasawa T, Miyakawa Y (1975) Laboratory model of membranous glomerulonephritis in rats induced by pronasedigested homologous renal tubular epithelial antigen. Lab Invest 33:141–152
Naruse T, Fukasawa T, Umegae S, Oite S, Miyakawa Y (1978) Experimental membranous glomerulonephritis in rats: Correlation of ultrastructural changes with the serum level of autologous antibody against tubular antigen. Lab Invest 39:120–134
Natori Y, Hyakawa I, Shibata S (1986) Passive Heymann nephritis with acute and severe proteinuria induced by heterologous antibody against renal tubular brush border glycoprotein gp108. Lab Invest 55:63–70
Natori Y, Hayakawa I, Shibata S (1987a) Identification of gpl08, a pathogenic antigen of passive Heymann nephritis, as dipeptidyl peptidase IV. Clin Exp Immunol 70:434–439
Natori Y, Hayakawa I, Shibata S (1987b) Heymann nephritis in rats induced by human renal tubular antigens: Characterization of antigen and antibody specificities. Clin Exp Immunol 69:33–40
Natori Y, Hayakawa I, Shibata S (1989) Role of dipeptidyl peptidase IV (gpl08) in passive Heymann nephritis. Am J Pathol 134:405–410
Neale TJ, Wilson CB (1982) Glomerular antigens in Heymann nephritis: Reactivity of eluted and circulating antibody. J Immunol 128:323–330
Neale TJ, Couser WG, Salant DJ, Lowenstein LM, Wilson CB (1982) Specific uptake of Heymann’s nephritic kidney eluate by rat kidney. Lab Invest 46:450–453
Niles J, Collins B, Baird L, Erikson M, Bradford D, Pan G, Hsiung CK, Schneeberger EE, Bhan A, McCluskey RT (1987) Antibodies reactive with a renal glycoprotein and deposits in membranous nephritis (Abstr). Kidney Int 31:338
Oite TM, Batsford SR, Mihatsch M, Takamiya H, Vogt A (1982) Quantitative studies of the in situ immune complex glomerulonephritis in the rat induced by planted cationized antigen. J Exp Med 155:460–474
Ozawa M, Yonezawa S, Sato E, Muramatsu T (1982) A new glycoprotein antigen common to teratocarcinoma, visceral endoderm and renal tubular brush border. Dev Biol 91:351–359
Perkinson DT, Baker PJ, Couser WG, Johnson R, Adler S (1985) Membrane attack complex deposition in experimental glomerular injury. Am J Pathol 120:121–136
Podack ER, Müller-Eberhard HJ (1979) Isolation of human Sprotein, an inhibitor of the membrane attack complex of complement. J Biol Chem 254:9908–9914
Ponticelli C (1986) Prognosis and treatment of membranous nephropathy. Kidney Int 29:927–940
Pruchno CJ, Burns MW, Schulze M, Johnson RJ, Baker PJ, Couser WG (1989) Urinary excretion of C5b-9 reflects disease activity in passive Heymann nephritis. Kidney Int 36:65–71
Quigg RJ, Cybulsky AV, Jacobs JB, Salant DJ (1988) Anti-F×1A produces complement dependent cytotoxicity in glomerular epithelial cells. Kidney Int 34:43–61
Rastogy SD, Hart-Mercer J, Kerr DNS (1968) Idiopathic membranous glomerulonephritis in adults: remission following steroid therapy. QJ Med 38:335–349
Raychowdhury R, Niles J, McCluskey RT, Smith JA (1989) Autoimmune target in Heymann nephritis is a glycoprotein with homology to the LDL receptor. Science 244:1163–1165
Rodman JSD, Kerjaschki D, Merisko EC, Farquhar MG (1984) Presence of an extensive clathrin coat on the apical plasmalemma of the rat kidney proximal tubule cell. J Cell Biol 98:1630–1636
Ronco P, Melcion C, Geniteau E, Ronco L, Reininger P, Galceran P, Verroust P (1984a) Production and characterization of monoclonal antibodies against rat brush border antigens of the proximal convoluted tubule. Immunology 53:78–95
Ronco P, Allegri L, Melcion C, Pirotsky E, Appay MD, Bariety J, Pontillon F, Verroust P (1984b) A monoclonal antibody to brush borders and passive Heymann nephritis. Clin Exp Immunol 55:319–332
Ronco P, Neale TJ, Wilson CB, Galceran M, Verroust P (1986) An immunopathological study of a 330 kD protein defined by monoclonal antibodies and reactive with anti-RTEa5 antibodies and kidney eluates from active Heymann nephritis. J Immunol 136:125–130
Ronco P, Van Leer EHG, Chatelet F, Tauc M, Verroust P (1987) Brush border hydrolases expressed by glomerular epithelial cells are target antigens for the formation of immune deposits. Kidney Int 31:329a (Abstr)
Rosen S (1971) Membranous glomerulonephritis: Current status. Human Pathol 2:209–241
Sahali D, Mulliez N, Chatelet F, Dupuis R, Ronco P, Verroust P (1988) Characterization of a 280 kD protein restricted to the coated pits of the renal brush border and the epithelial cells of the yolk sac: Teratogenic effect of the specific monoclonal antibodies. J Exp Med 167:213–218
Salant D, Belok S, Madaio MP, Couser WG (1980) A new role for complement in experimental membranous nephropathy in rats. J Clin Invest 66:1339–1351
Schulze M, Baker PJ, Perkinson DT, Johnson RJ, Ochi RF, Stahl RAK, Couser WG (1989) Increased urinary excretion of C5b-9 distinguishes passive Heymann nephritis from other forms of experimental glomerulonephritis in the rat. Kidney Int 35:60–78
Sugisaki TJ, Klassen J, Andres GA, Milgrom FJ, McCluskey RT (1973) Passive transfer of Heymann’s nephritis with serum. Kidney Int 3:66–73
Thoenes W (1973) Pathohistologische Systematik der Glomerulonephritis — unter Berücksichtigung klinischer Aspekte. Nieren- und Hochdruckkrank 5:199–207
Thoenes G, Pielsticker K, Schubert G (1979) Transplantation-induced immune complex disease in rats with unilateral manifestation in the allografted kidney. Lab Invest 41:321–333
VanDamme BJC, Fleuren GJ, Bakker WW, Vernier RL, Hoedemaeker PhJ (1978) Experimental glomerulonephritis in the rat induced by antibodies directed against tubular antigens. V. Fixed glomerular antigens in the pathogenesis of heterologous immune complex nephritis. Lab Invest 38:502–510
Verroust P (1989) Nephrology Forum: Kinetics of immune deposits in membranous nephropathy. Kidney Int 1418–1428
Vogt A (1984) New aspects of the pathogenesis of immune complex glomerulonephritis: Formation of subepithelial deposits. Clin Nephrol 21:15–20
Whitworth J, Liebowitz S, Kennedy M, Cameron J, Evans D, Glassock R, Schoenfeld L (1976) Absence of glomerular renal epithelial antigen in membranous glomerulonephritis. Clin Nephrol 5:159–167
Zager RA, Couser WG, Andrews BS, Bolton WK, Pohl MA (1979) Radioimmunologic search for anti-tubular epithelial antibodies and circulating immune complexes in patients with membranous nephropathy. Nephron 24:10–16
Zanetti M, Mandet C, Duboust A, Bedrosiian J, Bariety J (1981) Demonstration of a passive Heymann-nephritis like mechanism in human kidney transplants. Clin Nephrol 15:272–288
Zollinger HU, Mihatsch JM (1978) Renal pathology in biopsy. Springer, Berlin Heidelberg New York, pp 261–278
Author information
Authors and Affiliations
Additional information
Supported by the Fonds zu Förderung der Wissenschaftlichen Forschung, Projekt No. P7712Med
Synonyms: Epimembranous glomerulonephritis; membranous glomerulopathy; extramembranous glomerulonephritis; transmembranous glomerulopathy; type II-nephritis (Ellis)
Prof. H.V. Zollinger in memoriam
Rights and permissions
About this article
Cite this article
Kerjaschki, D. The pathogenesis of membranous glomerulonephritis from morphology to molecules. Virchows Archiv B Cell Pathol 58, 253–271 (1989). https://doi.org/10.1007/BF02890080
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02890080