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The vitamin D3 receptor in the context of the nuclear receptor superfamily

The central role of the retinoid X receptor

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Abstract

The nuclear hormone 1 α,25-dihydroxyvitamin D3 (VD) is an important regulator of calcium homeostasis and is also a modulator of the cell cycle. The genomic actions of the hormone are mediated by a single transcription factor, the vitamin D3 receptor (VDR). On the majority of the known VD response elements, VDR binds as heterodimeric complex with the retinoid X receptor (RXR), which is a member of the nuclear receptor superfamily like VDR. RXR supports not only the DNA binding affinity and specificity of VDR, but allosterically also its transactivation properties. Moreover RXR is a partner in other hormone response systems, which supports the idea that the different nuclear hormone signaling pathways are functionally linked.

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    Carsten Carlberg PhD

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Carlberg, C. The vitamin D3 receptor in the context of the nuclear receptor superfamily. Endocr 4, 91–105 (1996). https://doi.org/10.1007/BF02782754

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