Summary
The development of the mucosal immune system in the human fetus has been studied in some detail. Aggregates of T and B cells form early Peyer's patches by 16 weeks gestation and by 19 weeks organised Peyer's patches with T and B cell zones are seen. T cells populate the mucosal lamina propria and epithelium from 11 weeks gestation and increase in number thereafter. As in the adult, most intrepithelial lymphocytes are CD8+ and most lamina propria T cells are CD4+. By 20 weeks, villus epithelial cells are HLA-DR+ and secretory component is also expressed. In the absence of lumenal stimulation in the fetus there is no intestinal secretory IgA antibody response. A few IgA plasma cells are present in fetal salivary glands but the number does not dramatically increase until after birth.
References
Bockman DE, Cooper MD, Early lymphoepithelial relationships in human appendix. A combined light and electron microscopic study. Gastreanterology 68: 1160, 1975.
Bridges RA, Condie RM, Zak SJ, Good RA, The morphologic basis of antibody formation development during the neonatal period. J Lab Clin Med 53: 331, 1959
Cornes JS, Number size and distribution of Peyer's pathches in the human small intestine. 1. The development of Peyer's patches. Gut 6: 225, 1965.
Eberl-Rothe G, Langegger PA, Über die Entwicklung der Peyerschen Platten. Z Anat Entwicklungsgeschichte 117:26, 1953
Iwase T, Moro I, Mestecky J, Immunohistochemical study of the ontogeny of the secretory immune system. In: McGhee JR, Mestecky J, Ogra PL, Bienenstock J (eds) Recent advances in mucosal immunology. Advances in experimental medicine and biology. Plenum, New York, p 1359, 1987
Janossy G, Tidman N, Selby WS, Thomas JA, Granger S, Kung PC, Goldstein G, Human T lymphocytes of inducer and suppressor type occupy different microenvironments. Nature 288: 81, 1980
MacDonald TT, Ontogeny of the immune system of the gut. CRC Press, Boca Raton, 1990.
MacDonald TT, Spencer J, Evidence that activated mucosal T cells play a role in the pathogenesis of enteropathy in human small intestine. J Exp Med 167: 1341, 1988
MacDonald TT, Weinel A, Spencer J, HLA-DR expression in human fetal intestinal epithelium. Gut 29: 1342, 1988
Mellander L, Carlsson B, Hanson LA, Secretory IgA and IgM antibodies toE. coli and poliovirus type 1 antigens occur in amniotic fluid, meconium and saliva from newborns. A neonatal immune response without antigenic exposure: a result of anti-idiotypic induction? Clin Exp Immunol 63: 555, 1986
Monk TJ, Spencer J, Cerf-Bensussan N, MacDonald TT, Activation of mucosal T-cells in situ with anti-CD3 antibody: phenotype of the activated T cells and their distribution within the mucosal micro-environment. Clin Exp Immunol 74: 216, 1988
Moxey PC, Trier JS, Specialised cell type in the human fetal small intestine. Anat Rec 191: 269, 1978
Ogra SS, Ogra PL, Lippes J, Tomasi TB, Immunohistologic localization of immunoglobulins, secretory component, and lactoferrin in the developing human fetus. Proc Soc Exp Biol Med 139: 570, 1972
Orlic D, Lev R, A electronmicroscopic study of intraepithelial lymphocytes in human fetal small intestine. Lab Invest 37: 554, 1977
Perkkio M, Savilahti E, Time of appearance of immunoglobulin-containing cells in the mucosa of the neonatal intestine. Pediatr Res 14: 953, 1980
Petit JC, Galinha A, Salomon J-C, Immunoglobulins in the intestinal content of the human fetus with special reference to IgA. Eur J Immunol 3: 373, 1973
Scott H, Solheim BG, Brandtzaeg P, Thorsby E, HLA-DR-like antigens in the epithelium of the human small intestine. Scand J Immunol 12: 77, 1980
Selby WS, Janossy G, Mason DY, Jewell DP, Expression of HLA-DR antigens by colonic epithelium in inflammatory bowel disease. Clin Exp Immunol 53: 614, 1983
Silverstein AM, Lukes RJ, Fetal response to antigenic stimulus. 1. Plasmacellular and lymphoid reactions in the human fetus to intrauterine infection. Lab Invest 11: 918, 1962
Spencer J, Dillon SB, Isaacson PG, MacDonald TT, T cell sub-classes in fetal human ileum. Clin Exp Immunol 65: 553, 1986
Spencer J, Finn T, Isaacson PG, Human Peyer's patches: an immunohistochemical study. Gut 27: 405, 1986
Spencer J, MacDonald TT, Isaacson PG, Heterogeneity of nonlymphoid cells expressing HLA-D region antigens in human fetal gut. Clin Exp Immunol 67: 415, 1987
Spencer J, Isaacson PG, Diss TC, MacDonald TT, Expression of disulfide-linked and non-disulfide linked forms of the T cell receptor gamma/delta heterodimer in human intestinal intraepithelial lymphocytes. Eur J Immunol 19: 1335, 1989
Spencer J, Isaacson PG, Walker-Smith JA, MacDonald TT, Heterogencity of intraepithelial sub-populations in fetal and post-natal intestine. J Pediatr Gastroenterol Nutr 9: 173, 1989
Spencer J, MacDonald TT, Diss TC, Walker-Smith JA, Ciclitira PJ, Isaacson PG, Changes in intraepithelial lymphocyte subpopulations in coeliac disease and enteropathy associated T cell lymphoma (malignant histiocytosis of the intestine). Gut 30: 339, 1989
Takemura T, Eishi Y, Distribution of secretory component and immunoglobulins in the developing lung. Am J Dig Dis 131: 130, 1985
Thrane PS, Rognum TO, Huitfeldt HS, Brandtzaeg P, The distribution of HLA-DR determinants, secretory component, amylase, lysozyme, IgA, IgM and IgD in fetal and postnatal salivary glands. In: McGhee JR, Mestecky J, Ogra PL, Bienenstock J (eds) Recents advances in mucosal immunology, Advances in experimental medicine and biology. Plenum, New York, p 1431, 1987
Thrane PS, Rognum TO, Brandtzaeg P, Ontogenesis of the secretory immune system and innate defence factors in human parotid glands. Clin Exp Immunol 86: 342, 1991
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Braegger, C.P., Spencer, J. & MacDonald, T.T. Ontogenetic aspects of the intestinal immune system in man. Int J Clin Lab Res 22, 1–4 (1992). https://doi.org/10.1007/BF02591385
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DOI: https://doi.org/10.1007/BF02591385