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Transplantation of isologous islets of langerhans in diabetic rats

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Summary

Isologous isolated islets of Langerhans were transplanted into the peritoneum and, via the portal vein, into the liver of diabetic rats. In both groups almost normal blood glucose and serum insulin levels were achieved for a period of three months. Glucose tolerance tests were markedly improved. Morphological examination of the transplanted islets and immunohistochemical tests for insulin and glucagon showed the liver to be a more suitable site for islet grafting than the peritoneum.

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Authors and Affiliations

  1. Department of Surgery and Anatomy, Ernst-Moritz-Arndt-University, Greifswald

    Dietmar Lorenz, Jürgen Petermann, Ruthard Beckert, Klaus-Dieter Rosenbaum, Manfred Ziegler & Alfred Dorn

  2. Zentralinstitut für Diabetes «Gerhardt Katsch», Karlsburg

    Dietmar Lorenz, Jürgen Petermann, Ruthard Beckert, Klaus-Dieter Rosenbaum, Manfred Ziegler & Alfred Dorn

Authors
  1. Dietmar Lorenz
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  2. Jürgen Petermann
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  3. Ruthard Beckert
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  4. Klaus-Dieter Rosenbaum
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  5. Manfred Ziegler
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  6. Alfred Dorn
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Lorenz, D., Petermann, J., Beckert, R. et al. Transplantation of isologous islets of langerhans in diabetic rats. Acta diabet. lat 12, 30–40 (1975). https://doi.org/10.1007/BF02581110

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  • DOI: https://doi.org/10.1007/BF02581110

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