Abstract
Experimental studies were done on rats on compensatory absorptive capacity following Martin's operation for extensive aganglionosis. Experimental aganglionosis was produced in the descending colon of rats by serosal application of 0.1% benzalkonium chloride solution. Wide side-toside anastomosis was performed between the aganglionic colon and the distal ileum, removing the remaining colon. As to absorptive capacity of water and electrolytes, this experimental intestine was compared, with other intestines, especially control intestine, in which similar side-to-side anastomosis was done between the normal colon and the normal ileum. “Experimental” as well as control intestine showed higher absorptive capacities of water, Na and Cl per unit length than did summed up values of the ileum and the colon per unit length. Postoperative body weight curves showed fairly good increases and appearance of feces showed a fair improvement in the experimental group. Autopsy of experimental intestine revealed marked dilatation of the anastomosed ileum and mucosal hypertrophy of the anastomosed colon. These results suggested a favorable compensatory absorptive capacity following Martin's operation.
Similar content being viewed by others
References
Martin, L.W.: Surgical management of Hirschsprung's disease involving the small intestine. Arch. Surg. 97: 183–189, 1968.
Martin, L.W.: Surgical management of total colonic aganglionosis. Ann. Surg. 176: 343–346, 1972.
Prevot, J., Bodart, N., Babut, J.M. and Mourot, M.: Hirschsprung's disease with total colonic involvement. Therapeutic problems, Progr. Pediatr. Surg. 4: 63–89, 1972.
Burrington, J.D. and Wayne, E.R.: Modified Duhamel procedure for treatment of total aganglionic colon in childhood. J. Pediatr. Surg. 11: 391–398, 1976.
Sato, A., Yamamoto, M., Imamura, K., Kashiki, Y., Kunieda, T. and Sakata, K.: Pathophysiology of aganglionic colon and anorectum: an experimental study on aganglionosis produced by a new method in the rat. J. Pediatr. Surg. 13: 399–405, 1978.
Sakata, K., Kunieda, T., Furuta, T. and Sato, A.: Selective destruction of intestinal nervous elements by local application of benzalkonium solution in the rat. Experientia 35: 1611–1612, 1979.
Suzuki, J.: Study on water and electrolytes transport in the rat intestine. Jap. J. Gastroenterology 70: 673–682, 1973.
Reynell, P.C. and Spray, G.H.: The simultaneous measurement of absorption and transit in the gastro-intestinal tract of the rat. J. Physiol. 131: 452–462, 1956.
Deveroede, G.J. and Phillips, S.F.: Studies of the perfusion technique for colonic absorption. Gastroenterology 56: 92–199, 1969.
Curran, P.F. and Solomon, A.K.: Ion and water fluxes in the ileum of rats. J. Gen. Physiol. 41: 143–168, 1957.
Schanker, L.S., Tocco, D.J., Brodie, B.B. and Hogben, C.A.M.: Absorption of drugs from the rat small intestine. J. Pharmacol. Exp. Ther. 123: 81–88, 1958.
Levitan, R., Fordtran, J.S., Burrows, B.A. and Ingelfinger, F.J.: Water and salf absorption in the human colon. J. Clin. Invest. 41: 1754–1759,. 1962.
Wright, H.K., Poskitt, T., Cleveland, J.C. and Herskovic, T.: Effect of colon resection on morphology and absorptive capacity of ileum in the rat. Gastroenterology 54: 1285, 1968.
Wright, H.K., Cleveland, J.C., Tilson, M.D. and Herskovic, T.: Morphology and absorptive capacity of the ileum after ileostomy in man. Amer. J. Surg. 117: 242–245, 1969.
Wright, H.K., Poskitt, T., Cleveland, J.C. and Herskovic, T.: The effect of total colectomy on morphology and absorptive capacity of ileum in the rat. J. Surg. Res. 9: 301–304, 1969.
Masesa, P.C.: Changes in the rat small intestine after subtotal colectomy, J. Physiol. 256: 47p, 1976.
Masesa, P.C. and Forrester, J.M.: Consequences of partial and subtotal colectomy in the rat. Gut 18: 37–44, 1977.
Perrault, J., Stockwell, M., Stephens, C. and Forstner, G.: Malabsorption and pouch ulcerations following the Martin repair for total colonic aganglionosis. J. Pediatr. Surg. 14: 458–461, 1979.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kunieda, T., Hosono, Y. & Sakata, K. Experimental studies on intestinal absorption following Martin's operation. The Japanese Journal of Surgery 11, 481–484 (1981). https://doi.org/10.1007/BF02469035
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02469035