Summary
In calvaria cells cultured for 6 days in the presence of dichloromethanediphosphonate (Cl2MDP) (0.025 – 250 µM), the synthesis of prostaglandin E2 (PGE2) was inhibited by up to 90 %. Inhibition of PGE2 synthesis might be one mechanism whereby this diphosphonate inhibits bone resorption. This effect is not common to all diphosphonates since 25 µM 3-amino-1-hydroxypropane-1,1-diphosphonate (AHPDP) stimulated the synthesis of PGE2.
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Felix, R., Bettex, JD. & Fleisch, H. Effect of diphosphonates on the synthesis of prostaglandins in cultured calvaria cells. Calcif Tissue Int 33, 549–552 (1981). https://doi.org/10.1007/BF02409488
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DOI: https://doi.org/10.1007/BF02409488