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Local recurrence and survival in soft-tissue sarcomas

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Abstract

Background: There is a continuous interest in the literature concerning the management and survival after treatment of local recurrence in sarcomas because it is one of the most common types of recurrence.

Design: We retrospectively reviewed 93 patients treated for local recurrence from soft-tissue sarcoma.

Methods: We evaluated prognostic parameters (grade, tumor size, location) and the effect of treatment on survival.

Results: Resection of all the gross tumor at first visit to our Institute for local recurrence was accomplished in 88 patients (95%). Of the 59 patients with extremity tumors, six (10%) required an amputation. At a mean follow-up of 66 months, further local recurrence was noted in 27%. The estimated 5-year survival rate was 100% for patients with grade I tumors (n=16), 77% for grade II (n=31), and 45% for grade III tumors (n=46) (p=0.0002). This value was 78% for tumors ≤5 cm and 57% for those >5 cm (p=0.03).

Conclusions: Local recurrence is resectable and limb preservation is possible in the majority of patients. The overall 5-year survival rate was 65%. Survival after treatment of local recurrence is determined mainly by the grade and secondarily by the size of the tumor as for primary sarcomas.

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References

  1. Vezeridis MP, Moore R, Karakousis CP. Metastatic patterns in soft-tissue sarcomas.Arch Surg 1983;118:915–8.

    CAS  PubMed  Google Scholar 

  2. Yang JC, Glatstein EJ, Rosenberg SA, Antman KH. Sarcomas of soft tissues. In: DeVita VT jr, Hellman S, Rosenberg SA, eds.Cancer. Principles and practice of oncology. 4th ed. Philadelphia: JB Lippincott, 1993:1436–88.

    Google Scholar 

  3. Mazeron JJ, Suit HD. Lymph nodes as sites of metastases from sarcomas of soft tissue.Cancer 1987;60:1800–8.

    CAS  PubMed  Google Scholar 

  4. Weiss SW, Enzinger FM. Malignant fibrous histiocytoma: an analysis of 200 cases.Cancer 1978;41:2250–66.

    CAS  PubMed  Google Scholar 

  5. Karakousis CP, Blumenson LE, Canavese G, Rao U. Surgery for disseminated abdominal sarcoma.Am J Surg 1992;163:560–4.

    Article  CAS  PubMed  Google Scholar 

  6. Karakousis CP, Emrich J, Rao U, Khalil M. Limb salvage in soft-tissue sarcomas with selective combination of modalities.Eur J Surg Oncol 1991;17:71–80.

    CAS  PubMed  Google Scholar 

  7. Eilber FR, Giuliamo AE, Huth R, Mirra JJ, Morton DL. High grade soft-tissue sarcomas of the extremity: UCLA experience with limb salvage. In: Wagener DJT, ed.Primary chemotherapy in cancer medicine. New York: Alan R Liss, 1985:59–74.

    Google Scholar 

  8. Rosenberg SA, Tepper J, Glatstein E, et al. The treatment of soft-tissue sarcomas of the extremities: prospective randomized evaluation of 1) limb-sparing surgery plus radiation therapy compared with amputation and 2) the role of adjuvant chemotherapy.Ann Surg 1982;196:305–15.

    CAS  PubMed  Google Scholar 

  9. Lindberg RD, Martin RG, Romsdahl MM, Barkley HT. Conservative surgery and postoperative radiotherapy in 300 adults with soft- tissue sarcomas.Cancer 1981;47:2391–7.

    CAS  PubMed  Google Scholar 

  10. Abbas JS, Holyoke ED, Moore R, Karakousis CP. The surgical treatment and outcome of soft-tissue sarcoma.Arch Surg 1981;116:765–9.

    CAS  PubMed  Google Scholar 

  11. Shiu MH, Castro EB, Hajdu SI, Fortner JC. Surgical treatment of 297 soft-tissue sarcomas of the lower extremity.Ann Surg 1975;182:597–602.

    CAS  PubMed  Google Scholar 

  12. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations.J Am Stat Assoc 1958;53:457–86.

    Google Scholar 

  13. Cox DR. Regression models and life-tables.J R Stat Soc B 1971;34:187–220.

    Google Scholar 

  14. Suit HD, Mankin HJ, Wood WC, Proppes KH. Preoperative, intraoperative, and postoperative radiation in the treatment of primary soft-tissue sarcoma.Cancer 1985;55:2659–67.

    CAS  PubMed  Google Scholar 

  15. Brennan MF, Casper ED, Harrison LB, Shiu MH, Gaynor J, Hajdu SI. The role of multimodality therapy in soft-tissue sarcoma.Ann Surg 1991;214:328–38.

    CAS  PubMed  Google Scholar 

  16. Eilber FR, Eckardt JJ, Rosen G, Fu YS, Seeger LL, Selch MT. Neoadjuvant chemotherapy with radiotherapy in the multidisciplinary management of soft-tissue sarcomas of the extremity.Surg Oncol Clin North Am 1993;2:611–20.

    Google Scholar 

  17. Karakousis CP, Emrich LJ, Rao U, Khalil M. Selective combination of modalities in soft tissue sarcomas: limb salvage and survival.Semin Surg Oncol 1988;4:78–81.

    CAS  PubMed  Google Scholar 

  18. Karakousis CP, Emrich LJ, Rao U, Krishnamsetty RM. Feasibility of limb salvage and survival in soft tissue sarcomas.Cancer 1986;57:484–91.

    CAS  PubMed  Google Scholar 

  19. Potter DA, Kinsell T, Glatstein E, et al. High-grade soft tissue sarcomas of the extremities.Cancer 1986;58:190–205.

    CAS  PubMed  Google Scholar 

  20. Potter DA, Glenn J, Kinsella T, et al. Patterns of recurrence in patients with high-grade soft tissue sarcomas.J Clin Oncol 1985;3:353–66.

    CAS  PubMed  Google Scholar 

  21. Giuliano AE, Eilber FR, Morton DL. The management of locally recurrent soft-tissue sarcoma.Ann Surg 1982;196:87–91.

    CAS  PubMed  Google Scholar 

  22. Lawrence W Jr, Donegan WL, Nachimuth N, et al. Adult soft tissue sarcomas. A pattern of care survey of the American College of Surgeons.Ann Surg 1987;205;349–59.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. From the Millard Fillmore Hospitals, State University of New York, and Roswell Park Cancer Institute, Buffalo, New York

    Constantine P. Karakousis MD, PhD

  2. Montefiore University Hospital, Pittsburgh, Pennsylvania, USA

    Uma Rao MD

Authors
  1. Constantine P. Karakousis MD, PhD
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  2. C. Proimakis MD
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  3. Uma Rao MD
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  4. Augustine F. Velez MD
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  5. Deborah L. Driscoll BA
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Karakousis, C.P., Proimakis, C., Rao, U. et al. Local recurrence and survival in soft-tissue sarcomas. Annals of Surgical Oncology 3, 255–260 (1996). https://doi.org/10.1007/BF02306280

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  • DOI: https://doi.org/10.1007/BF02306280

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