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Doxorubicin cardiotoxicity detected by indium 111 myosin-specific imaging

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Abstract

A patient with primary hepatoma, treated with doxorubicin and presenting with atypical electrocardiographic findings, was investigated with myosin-specific monoclonal antibody radiolabelled with indium-111. Despite a normal ejection fraction, myosin-specific scintigraphy was positive, indicating doxorubicin cardiotoxicity.

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References

  • Alexander J, Dainiak N, Berger HJ et al. (1979) Serial assessment of doxorubicin cardiotoxicity with quantitative radionuclide angiocardiography. N Engl J Med 300:278–283

    PubMed  Google Scholar 

  • Carrio I, Berna L, Estorch M et al. (1989) Noninvasive follow-up of heart transplant patients with quantitative In-111 antimyosin scintigraphy (abstract). J Nucl Med 30:862

    Google Scholar 

  • Carrio I, Berna L, Estorch M, Duncker G (1990) Risk stratification of heart transplant patients during long term follow-up by means of In-111 antimyosin scintigraphy (abstract). Eur J Nucl Med 16:391

    Article  Google Scholar 

  • Jain D, Crawley JC, Lahiri A, Rafley EB (1990) Indium-111 antimyosin images compared with triphenyl tetrazolium chloride staining in a patient six days after myocardial infarction. J Nucl Med 31:231–233

    PubMed  Google Scholar 

  • Johnson LL, Seldin DW, Becker LC et al. (1989) Antimyosin imaging in acute transmural myocardial infarction: results of a multicenter clinical trial. J Am Coll Cardiol 13:27–35

    PubMed  Google Scholar 

  • Khaw B, Fallon J, Beller G et al. (1979) Specificity of localization of myosin specific antibody fragments in experimental myocardial infarction. Circulation 60:1527–1531

    PubMed  Google Scholar 

  • Khaw B, Scott J, Fallon J et al. (1982) Myocardial injury quantification by cell sorting initiated with antimyosin fluorescent spheres. Science 217:1050–1053

    PubMed  Google Scholar 

  • Khaw B, Yasuda T, Gold H et al. (1987) Acute myocardial infarct imaging with indium-111 labelled monoclonal antibody fab. J Nucl Med 28:1671–1678

    PubMed  Google Scholar 

  • Marchandise B, Schroeder E, Bosly A et al. (1989) Early detection of doxorubicin cardiotoxicity: interest of Doppler echocardiographic analysis of left ventricular filling dynamics. Am Heart J 118:92–98

    Article  PubMed  Google Scholar 

  • Mason JW, Bristow MR, Billingham ME, Daniel JR (1976) Invasive and non invasive methods of assessing Adriamycin cardiotoxic effects in man: superiority of histopathologic assessment using endomyocardial biopsy. Cancer Treat 62:857–864

    Google Scholar 

  • Obrador D, Ballester M, Carrio I, Berna L, Pons-Llado G (1989a) High prevalence of myocardial antimyosin antibody uptake in patients with chronic idiopathic dilated cardiomyopathy. J Am Coll Cardiol 13:1289–1293

    PubMed  Google Scholar 

  • Obrador D, Ballester M, Carrio I et al. (1989b) Monoclonal antibody studies vs light microscopy in the detection of myocyte damage (abstract). Eur Heart J 10:247

    Google Scholar 

  • Yasuda T, Palacios I, Dec GW et al. (1987) Indium-111 monoclonal antibody imaging in the diagnosis of acute myocarditis. Circulation 76:306–311

    PubMed  Google Scholar 

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Lekakis, J., Vassilopoulos, N., Psichoyiou, H. et al. Doxorubicin cardiotoxicity detected by indium 111 myosin-specific imaging. Eur J Nucl Med 18, 225–226 (1991). https://doi.org/10.1007/BF02262734

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  • DOI: https://doi.org/10.1007/BF02262734

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