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Protective effect of tetramethylpyrazine on absolute ethanol-induced renal toxicity in mice

  • Original Paper
  • Published:
Journal of Biomedical Science

Abstract

Acute administration of absolute ethanol (10 ml/kg) per os to fasted mice produced extensive renal failure as measured by a rise in blood urea nitrogen and creatinine. Pretreatment with oral administration of tetramethylpyrazine (TMP) prevented such failure. The maximal effect against absolute ethanol-induced renal failure could be observed 1 h after TMP administration. In order to further investigate the renal protective mechanism of TMP, experiments on lipid peroxidation and superoxide scavenging activity were conducted. Renal homogenates made from mice treated with ethanol showed that TMP pretreatment had an antioxidant effect. Mice in acute renal failure had higher malonic dialdehyde concentrations than those pretreated with TMP. The renal protective mechanism of TMP was attributed, in part, to its prominent superoxide scavenging effect, which protects the kidney from superoxide-induced renal damage.

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Authors and Affiliations

  1. National Taipei College of Nursing, Taipei Medical University, Taiwan, ROC

    Chi-Feng Liu

  2. Medical Research Institute, Taipei Medical University, Taiwan, ROC

    Mei-Hsiu Lin

  3. Department of Experimental Diagnosis, Taipei Medical University Hospital, Taipei

    Hui-Wen Chang

  4. Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC

    Chun-Ching Lin

  5. Department of Medicine, Taipei Medical University, 250, Wu-hsing Street, Taipei, Taiwan (ROC)

    Song-Chow Lin PhD (Professor of Pharmacology)

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Liu, CF., Lin, MH., Lin, CC. et al. Protective effect of tetramethylpyrazine on absolute ethanol-induced renal toxicity in mice. J Biomed Sci 9, 299–302 (2002). https://doi.org/10.1007/BF02256584

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  • DOI: https://doi.org/10.1007/BF02256584

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