Abstract
Experimental gastric ulcers, produced by submucosal injection of acetic acid in rats were studied in relationship to healing. Small ulcers healed completely within 40 days after induction; moderately severe ulcers were sometimes found at 150 days, and probably resulted from repeated healing and reulceration. Large severe ulcers partially healed and then became reexacerbated; they frequently increased in size up to 250 days, thus resembling chronic gastric lesions. Throughout the experimental periods, adhesion of the ulcer base with adjacent organs and delayed gastric emptying were found in most animals. After ulceration, an increase in gastric volume and acid output and a decrease in protease activity of gastric contents were found in chronic fistula rats with experimental ulcers. The secretory changes observed here may have been secondary to gastric ulceration and/or delayed gastric emptying. The factors responsible for the reexacerbation of the experimental ulcer remain unidentified.
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Flood CA, Howes EL: Experimental study of the effect of histamine on the healing of gastric defects-artificial gastric ulcer. Surg Gynecol Obstet 58:136, 1934
Janowitz HD, Weinstein VA, Shaer RG, Cereghini JF, Hollander F: The effect of cortisone and corticotropin on the healing of gastric ulcer. An experimental study. Gastroenterology 34:11, 1958.
Kahn DS, Phillips MJ, Skoryna SC: Chronic experimental gastric ulcer in the rat receiving intermittent cortisone administration. Exp Mol Pathol 2:481, 1963
Skoryna SC, Webster DR, Kahn DS: A new method of production of experimental gastric ulcer. The effects of hormonal factors of healing. Gastroenterology 34:1, 1958
Friedman JC, Hamburger WW: Experimental chronic gastric ulcer. JAMA 58:380, 1914
Rigler SP, Oberhelman HA, Brasher PH, Landor JH, Dragstedt LR: Pvloric stenosis and gastric ulcer. Arch Surg 71:191, 1955
Dragstedt LR, Vaughn AM: Gastric ulcer studies. Arch Surg 8:791, 1924
Williams AW: The healing of experimental gastric ulcers. Br J Surg 48:564, 1961
Takagi K, Okabe S, Saziki R: A new method for the production of chronic gastric ulcer in rats and the effect of several drugs on its healing. Jap J Pharmacol 19:418, 1970
Okabe S, Roth JLA, Pfeiffer CJ: Differential healing periods of the acetic acid ulcer model in rats and cats. Experientia 27:146, 1971
Okabe S, Pfeiffer CJ: The acetic acid ulcer model—a procedure for chronic duodenal or gastric ulcer, Peptic Ulcer. Edited by CJ Pfeiffer. Copenhagen, Munksgaard, 1971, pp 13–20
Brodie DA, Hanson HM: A study of the factors involved in the production of gastric ulcers by the restraint technique. Gastroenterology 38:353, 1960
Alphin RS, Lin TN: Preparation of chronic denervated gastric pouches in the rat. Am J Physiol 197:257, 1959
Chiang L, Sanchez-Chiang L, Wolf S, Tang J: The separate determination of human pepsin and gastricsin. Proc Soc Exp Biol Med 122:700, 1966
Ivy AC, Grossman MI, Bachrach WH: Rate of healing of acute and chronic ulcers, Peptic Ulcer. Philadelphia, Blakiston, 1950, pp 146–154
Haubrich WS: The clinical recognition and pathological anatomy of intractability of peptic ulcer disease. Ann NY Acad Sci 99:114, 1962
Haubrich WS, Roth JLA, Bockus HL: The clinical significance of penetration and confined perforation in peptic ulcer disease. Gastroenterology 25:173, 1953
Norris JR, Haubrich WS: The incidence and clinical features of penetration in peptic ulceration. JAMA 178:112, 1961
Okabe S, Roth JLA, Pfeiffer CJ: A method for experimental, penetrating gastric and duodenal ulcer in rats. Am J Dig Dis 16:277, 1971
Dragstedt LR, Woodward ER, Linares CA, et al: The pathogenesis of gastric ulcer. Ann Surg 160:497, 1964
Dragstedt LR, Woodward ER: Gastric stasis, a cause of gastric ulcer. Scand J Gastroenterol (Supple) 6:243, 1970
Beazell JM, Ivy AC: Chronic gastric ulcer following bilateral vagotomy in the rabbit and in the dog. Arch Pathol 22:213, 1936
Ivy AC, Fauley GB: The chronicity of ulcers in the stomach and upper intestine. Am J Surg 11:531, 1931
Brodie DA: The mechanism of gastric hyperacidity produced by pylorus ligation in the rat. Am J Dig Dis 11:231, 1966
Grossman MI: Stimulation of secretion of acid by distention of denervated fundic pouches in dogs. Gastroenterology 41:385, 1961
Grossman MI: Secretion of acid and pepsin in response to distention of vagally innervated fundic gland area in dogs. Gastroenterology 42:718, 1962
Grossman MI, Robertson CR, Ivy AC: Proof of a hormonal mechanism for gastric secretion—the humoral transmission of the distention stimulus. Am J Physiol 153:1, 1948
Crean GP: Observations on the regulation of the growth of the gastric mucosa, Gastric Secretion, Mechanisms and Control. Edited by TK Schnitka, JLA Gilbert, RC Harrison. Oxford, Pergamon Press, 1965, pp 33–39
Crean GP, Hogg DF, Rumsey RDE: Hyperplasia of the gastric mucosa produced by duodenal obstruction. Gastroenterology 56:193, 1969
Sircus W: Consideration on the effect of obstruction on gastric secretion, Gastric Secretion, Mechanisms and Control. Edited by TK Schnitka, JLA Gilbert, RC Harrison. Oxford, Pergamon Press, 1965, pp 293–302
Vagne M, Grossman MI: Gastric and pancreatic secretion in response to gastric distention in dogs. Gastroenterology 57:300, 1969
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Supported by the William H. Rorer Gastroenterology Research Fund.
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Okabe, S., Pfeiffer, C.J. Chronicity of acetic acid ulcer in the rat stomach. Digest Dis Sci 17, 619–629 (1972). https://doi.org/10.1007/BF02231748
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DOI: https://doi.org/10.1007/BF02231748