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Renal excretion of drugs during postnatal development in piglets

  • Comparative Pharmacology
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Abstract

The renal excretion of organic acids involves three mechanisms: glomerular filtration, active tubular secretion and passive tubular reabsorption. The postnatal development of each of these mechanisms was assessed in piglets. From birth to 8 weeks of life glomerular filtration rate (GFR) and clearance of p-amino-hippurate (PAH) rose twofold while the maximal tubular secretion of PAH (TmPAH) rose fourfold. Thus, the active secretion increased in parallel with GFR when the transport mechanism was unsaturated, whereas it increased about twofold more than GFR at saturation point. Age differences in the passive reabsorption were evaluated by using sulphachlorpyridazine (SCP) as test substance. Although the renal handling of SCP includes both secretion and reabsorption, the age-dependent rise in the ratio between clearance of ultrafiltrable SCP and GFR indicated a relative decrease in reabsorption with age.

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Authors and Affiliations

  1. Department of Pharmacology and Toxicology, Royal Veterinary and Agricultural University, 1870, Copenhagen V, Denmark

    Christian Friis

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  1. Christian Friis
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Friis, C. Renal excretion of drugs during postnatal development in piglets. Vet Res Commun 7, 349–352 (1983). https://doi.org/10.1007/BF02228644

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  • DOI: https://doi.org/10.1007/BF02228644

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