Summary
To demonstrate an as yet merely postulated generalized osteopathy in psoriatics, the serum calcium level, the alkaline phosphatase in the serum and the urinary excretion of hydroxyproline were evaluated in 24 patients with Ps and 24 patients with PA. Moreover, the bone bioptates from 25 patients with PA and 10 patients with Ps were examined histologically and measured morphometrically. The investigations provide evidence for the existence of a generalized “latent” osteopathy in terms of an elevated bone turnover rate without loss of bone volume (high turnover remodelling) in both patients with PA as well as those with Ps without arthritis. As a pathogenetically essential factor shared by dermatosis and “osteopathy”, latent vitamin D deficiency and/or D hormone resistance is discussed.
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References
Hoede, N., Morsches, B., Holzmann, H. Psoriasis — eine Allgemeinerkrankung. Internist 1974 15, 186–191.
Holzmann, H., Hoede, N., Hahn, K., Eissner, D., Knochenbefunde bei Psoriasis. Arch Dermatol Res 1978, 262, 191–196.
Holzmann, H., Altmeyer, P. Die psoriatische Osteoarthropathie aus dermatologischer Sicht. In: Arthritis und Spondylitis psoriatica, 73–81. Ed. F. Schilling, Darmstadt, Steinkopff, 1986.
Fassbender, H.G. Strukturen und Mechanismen extraartikulärer Knochenprozesse bei Osteoarthropathia psoriatica Therapiewoche 1981, 32, 4970–4976.
Fredrikson, T., Petterson, U. Severe psoriasis — oral therapy with an new retinoid. Dermatologica 1978, 157, 238–244.
Chalkins, E. Semi-quantitative criteria of estimating degrees of disease activity of rheumatoid arthritis. Committee Report to Am Rheum Assoc Juni 1962, quot. by Lansbury, 7. Methods of evaluating rheumatoid arthritis. Ed.: Hollander, J.L., In: Arthritis and Allied Conditions, Lea and Febiger, Philadelpha, 1972, p. 419–438.
Haury, H. Zur routinemässigen Bestimmung von Hydroxyprolin im Harn J Clin Chem Clin Biochem 1972, 10, 25–28.
Merz, W.A. Die Streckenmessung an gerichteten Strukturen im Mikroskop und ihre Anwendung zur Bestimmung von Oberflächen-Volumen-Relation im Knochengewebe Mikroskopie 1967, 22, 132–142.
Malluche, H.H., Fangerl, M.-F. Atlas of Mineralised Bone Histology, p. 38 Karger, München, Paris, London, New York, 1986.
Delling, G. Endokrine Osteopathie. Reihe: Veröff. aus der Pathologie G. Fischer, Stuttgart 1975, 98, 19–33.
Keiser, H.R., Sjoerdsma, A. Direct measurement of the rate of collagen synthesis in skin. Clin Chim Acta 23 (1969), 361–364.
Kreysel, H.W., Köhler, N. Die klinische Bedeutung der Hydroxyprolinausscheidung im Urin. Med Welt 1973, 24, 1654–1658.
Brunish, R., Sorensen, B. Urinary excretion of acid mucopolysaccharides and hydroxyproline in psoriasis. Dermatologica 1965, 130, 165–172.
Korting, G.W., Holzmann, H. Zur Hydroxyprolinausscheidung im Harn von Hautkranken Klin Wochenstr 1965, 43, 361–364.
Als, S.O., Gotfredsen, A., Christiansen, C. Relationship between local and total bone mineral in patients with rheumatoid arthritis and normal subjects. Clin Rheumatol 1983, 2, 265–271.
Hahn, T.J., Hahn, B.H. Osteopenia in patients with rheumatic diseases: principles of diagnosis and therapy. Arthritis Rheum 1976, 6, 165–188.
Reid, D.M., Kennedy, M.S.J., Nicoll, J., Smith, M.A., Tothill, P., Nuki, G. Total and peripheral bone mass in patients with psoriatic arthritis and rheumatoid arthritis. Clin Rheumatol 1986, 5, 372–378.
Als, S.O., Christiansen, C., Hellesen, C. Prevalence of decreased bone mass in rheumatoid arthritis: Relations to anti-inflammatory treatment. Clin Rheumatol 1984, 3, 201–208.
Cooper, C.W., Dety, S.B., Talmage, R.V. Inhibition of bone collagen synthesis by salicylates. Proc Soc Exp Biol Med 1964, 117, 881–888.
Lindholm, T.S., Tornkvist, H.. Inhibitory effect on formation and calcification exerted by the anti-inflammatory drug ibuprofen. Scand J Rheumatol 1981, 10, 38–42.
Feldmann, D., Chen, T., Hirst, M., Colston, K., Karasek, M., Cone, C. Demonstration of 1,25 dihydroxyvitamin D3-receptors in human skin biopsies. J Clin Endocrinol Metab 1980, 51, 1463–1465.
Simpson, R.U., de Luca, H.F. Characterisation of a receptor-like protein for 1,25-dihydroxyvitamin D3 in rat skin. Acad Proc Natl Sci 1980, 77, 5822–5826.
Fairley, H.A., Marcelo, C.L., Hogan, V.A., Vorhees, J. Increased calmodulin levels in psoriasis and low Ca++-regulated mouse epidermal keratinocyte cultures. J Invest Dermatol 1985, 84, 195–198.
Robinson, I.K., Freinkel, R.K., Gottschalk, S. Effect of retinoic acid and low calcium conditions of surface glyco-conjugates defined by differential lectin labelling in mouse epidermal cell culture. Br J Dermatol 1984, 110, 17–27.
Stanley, J.R., Yuspa, S.H. Specific epidermal protein markers modulated during calcium-induced terminal differentiation. J Cell Biol 1983, 96, 1809–1814.
Virvidakis, K., Brokalakis, J., Singhellakis, P., Mountekalakis, T. Effect of PUVA on intestinal calcium absorption. Br J Dermatol 1988, 118, 219–221.
Kragballe, H., Beck, H.I., Sogaard, H. Improvement of psoriaisis by a topical vitamin D3 analogue (MC 903) in a double-blind study. Br J Dermatol 1988, 119, 223–230.
Morimoto, S., Yoshikawa, K., Kozuka, K., Kitano, Y., Imanaka, S., Fukuo, K., Koh, E., Kumahara, Y. An open study of vitamin D3-treatment in psoriasis vulgaris. Br J Dermatol 1986, 115, 421–429.
Takamoto, S., Onishi, T., Morimoto, S., Imanaka, S., Yukawa, S., Kozuka, S., Kitano, Y., Seino, Y., Kumahara, Y. Effect of 1-alphahydroxycholecalciferol on psoriasis vulgaris: a pilot study. Calcif Tiss int 1986, 39, 360–364.
Gaillard, P. Parathyroid and bone tissue culture. In: The Parathyroids, Eds: Greep, R.O., R.V. Talmage. Springfield, Illinois, Thomas. 1961.
De Luca, H.F., Kleiner-Bossaller, A. Metaboliten von Vitamin D in der Regulation des Calcium- und Phosphatstoffwechsels. Mschr Kinderheilk 1973, 121, 329–337.
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Hein, G., Abendroth, K., Müller, A. et al. Studies on psoriatic osteopathy. Clin Rheumatol 10, 13–17 (1991). https://doi.org/10.1007/BF02208026
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DOI: https://doi.org/10.1007/BF02208026