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Anti-inflammatory and PG inhibitory effects of phenacetin and acetaminophen

  • Immunosuppression and Inflammation
  • Published:
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Abstract

Although acetaminophen and phenacetin do not inhibit PG synthesis when added directly to isolated rat platelets and when given orally, both drugs inhibit carrageenan-induced hindpaw edema — a widely used inflammatory assay method. It does not appear that the anti-inflammatory effects of these non-steroidal drugs (unlike other well-known non-steroidal drugs) can be explained on the basis of PG-synthetase inhibition.

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Authors and Affiliations

  1. The Upjohn Company, 49001, Kalamazoo, Michigan, USA

    E. Myles Glenn, Barbara J. Bowman & Norman A. Rohloff

Authors
  1. E. Myles Glenn
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  2. Barbara J. Bowman
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  3. Norman A. Rohloff
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Glenn, E.M., Bowman, B.J. & Rohloff, N.A. Anti-inflammatory and PG inhibitory effects of phenacetin and acetaminophen. Agents and Actions 7, 513–516 (1977). https://doi.org/10.1007/BF02111123

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  • DOI: https://doi.org/10.1007/BF02111123

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