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Changning pattern of chronic renal failure and renal replacement therapy in children and adolescents: a 20-year single centre study

  • Nephrology/Urology
  • Published:
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Abstract

We analysed the demographic data, clinical course and survival on different forms of renal replacement therapy (RRT) of 374 children and adolescents with chronic renal failure observed between 1969 and 1988 and compared the findings for the four subsequent 5-year periods. The proportion of children below 5 years of age rose from 21% to 47%. With time the incidence of glomerulonephritis increased and that of pyelonephritis decreased. As RRT became more common, more very young children and more adolescents were admitted to the study. In the last 5 years continuous ambulatory peritoncal dialysis (CAPD) and haemodialysis (HD) were performed to the same extent as the initial form of RRT. The time a subject had to wait for a first transplant decreased from 36 to 21 months. Between 1969 and 1988 overall survival on any form of RRT increased to 77% after 10 years of therapy. In the last observation period 2-year patient survival was 100% both on HD and CAPD. First cadaver graft survival after 4 years improved from 25% in 1969–1973 to 69% in 1984–1988.

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Abbreviations

CAPD:

continuous ambulatory peritoneal dialysis

CRF:

chronic renal failure

EDTA:

European Dialysis and Transplant Association

ESRD:

end-stage renal disease

HD:

hacmodialysis

RRT:

renal replacement therapy

SCr:

serum creatinine concentration

TP:

transplantation

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Authors and Affiliations

  1. Division of Paediatric Nephrology, Department of Paediatrics, University of Heidelberg, Im Neuenheimer Feld 150, W-6900, Heidelberg, Germany

    K. Schärer, U. Reiss, O. Mehls, N. Gretz, D. E. Müller-Wiefel & A. Wingen

  2. Division of Urology, Department of Surgery, University of Heidelberg, Im Neuenheimer Feld 150, W-6900, Heidelberg, Germany

    K. Möhring

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  1. K. Schärer
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  2. U. Reiss
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  3. O. Mehls
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  4. N. Gretz
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  5. K. Möhring
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  6. D. E. Müller-Wiefel
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  7. A. Wingen
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Schärer, K., Reiss, U., Mehls, O. et al. Changning pattern of chronic renal failure and renal replacement therapy in children and adolescents: a 20-year single centre study. Eur J Pediatr 152, 166–171 (1993). https://doi.org/10.1007/BF02072498

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  • DOI: https://doi.org/10.1007/BF02072498

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