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Once-daily administration of ceftriaxone in the treatment of meningitis and other serious infections in children

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Abstract

Forty-three children (ten neonates, 15 infants and 18 older children) were treated with single daily doses of ceftriaxone (50 to 100 mg/kg) intravenously or intramuscularly for serious bacterial infections. The infections included meningitis (31 patients), brain abscesses (four patients), septicaemia (three patients), pleuro-pneumonia (two patients), septic arthritis and soft tissue phlegmona (three patients). No other antibacterial agents were used except in four patients with brain abscesses, in whom ceftriaxone was combined with ornidazole. The overall bacteriological cure rate was 98%, and sterilisation of the cerebrospinal fluid occurred in 27 of 28 patients (96%) with proven bacterial meningitis. Two patients died, three survived with severe neurological sequelae; one neonate required partial gut resection. A complete clinical cure was achieved in the remaining 37 patients. Only one treatment failure was directly related to the drug therapy. The only side effects noted were sterilisation of the gut with overgrowth ofCandida albicans in 35% of neonates and infants, and prolonged fever in 13% of all patients. Ceftriaxone given in a 24-hourly regimen is convenient and highly effective in serious bacterial infections in children and is without significant toxicity.

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References

  1. Shelton, S., Nelson, J. D., McCracken, G. H.: In vitro susceptibility of gram-negative bacilli from pediatric patients to moxalactam, cefotaxime, Ro 13-9904, and other cephalosporins. Antimicrobial Agents and Chemotherapy 1980, 18: 476–479.

    PubMed  Google Scholar 

  2. McCracken, G. H., Nelson, J. D., Grimm, L.: Pharmacokinetics and bacteriological efficacy of cefoperazone, cefuroxime, ceftriaxone and moxalactam in experimentalStreptococcus pneumoniae andHaemophilus influenzae meningitis. Antimicrobial Agents and Chemotherapy 1982, 21: 262–267.

    PubMed  Google Scholar 

  3. Schaad, U. B., McCracken, G. H., Loock, C. A., Thomas, M. L.: Pharmacokinetics and bacteriological efficacy of moxalactam, cefotaxime, cefoperazone and rocephin in experimental bacterial meningitis. Journal of Infectious Diseases 1981, 143: 156–163.

    PubMed  Google Scholar 

  4. Patel, I. H., Miller, K., Weinfeld, R., Spicehandler, J.: Multiple intraveous dose pharmacokinetics of ceftriaxone in man. Chemotherapy 1981, Supplement 1, 27: 47–56.

    Google Scholar 

  5. Schaad, U. B., Stoeckel, K.: Single-dose pharmacokinetics of ceftriaxone in infants and young children. Antimicrobial Agents and Chemotherapy 1982, 21: 248–253.

    PubMed  Google Scholar 

  6. Del Rio, M., McCracken, G. H., Nelson, J. D., Chrane, D., Shelton, S.: Pharmacokinetics and cerebrospinal fluid bactericidal activity of ceftriaxone in the treatment of pediatric patients with bacterial meningitis. Antimicrobial Agents and Chemotherapy 1982, 22: 622–627.

    PubMed  Google Scholar 

  7. Steele, R. W., Eyre, L. B., Bradscher, R. W., Weinfeld, R. E., Patel, I. H., Spicehandler, J.: Pharmacokinetics of ceftriaxone in pediatric patients with meningitis. Antimicrobial Agents and Chemotherapy 1983, 23: 191–194.

    PubMed  Google Scholar 

  8. Chadwick, E. G., Yogev, R., Shulman, S. T., Weinfeld, R. E., Patel, I. H.: Single-dose ceftriaxone pharmacokinetics in pediatric patients with central nervous system infections. Journal of Pediatrics 1983, 102: 134–137.

    PubMed  Google Scholar 

  9. McCracken, G. H., Siegel, J. D., Threlkeld, N., Thomas, M.: Ceftriaxone pharmacokinetics in newborn infants. Antimicrobial Agents and Chemotherapy 1983, 23: 341–343.

    PubMed  Google Scholar 

  10. Bauer, A., Kirby, W., Sherris, J., Turck, M.: Antibiotic susceptibility testing by a standardizing single disc method. American Journal of Clinical Pathology 1966, 45: 493–496.

    PubMed  Google Scholar 

  11. Uchiyama, N., Greene, G. R., Kitts, D. B., Thrupp, L. D.: Meningitis due toHaemophilus influenzae type B resistant to ampicillin and chloramphenicol. Journal of Pediatrics 1980, 97: 421–424.

    PubMed  Google Scholar 

  12. Anderson, K. C., Maurer, M. J., Dajani, A. S.: Pneumococci relatively resistant to penicillin: a prevalence survey in children. Journal of Pediatrics 1980, 97: 939–941.

    PubMed  Google Scholar 

  13. Stoeckel, K., McNamara, P. J., Brandt, R., Plozza-Nottebrock, H., Ziegler, W. H.: Effects of concentration-dependent plasma protein binding on ceftriaxone kinetics. Clinical Pharmacology and Therapeutics 1981, 29: 650–657.

    PubMed  Google Scholar 

  14. Del Rio, M., Chrane, D., Shelton, S., McCracken, G. H., Nelson, J. D.: Ceftriaxone versus ampicillin and chloramphenicol for treatment of bacterial meningitis in children. Lancet 1983, 1: 1241–1244.

    PubMed  Google Scholar 

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  1. University Children's Hospital, Steinwiesstr. 75, 8032, Zurich, Switzerland

    E. Martin

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  1. E. Martin
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Martin, E. Once-daily administration of ceftriaxone in the treatment of meningitis and other serious infections in children. Eur. J, Clin. Microbiol. 2, 509–515 (1983). https://doi.org/10.1007/BF02013918

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