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Iron deposition in cranial bone marrow with sickle cell disease: MR assessment using a fat suppression technique

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Abstract

Thirteen patients with sickle cell disease (SCD) undergoing transfusion therapy and 8 control patients were examined by magnetic resonance imaging to discriminate bone marrow change due to iron deposition from hematologic marrow hyperplasia. Using T1-weighted spin echo images, only two subjects showed extremely low signal intensity marrow compatible with iron deposition. However, using T2-weighted fast spin echo images with fat suppression, cranial bone marrow in SCD patients with transfusion therapy showed considerably lower signal than that of controls. The main cause of marrow signal decrease in SCD patients with transfusion therapy was considered to be iron deposition due to repeated transfusion therapy rather than red marrow hyperplasia.

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Authors and Affiliations

  1. Department of Radiology, Tulane University Medical Center, 1430 Tulane Avenue, 70112-2699, New Orleans, LA, USA

    K. Kaneko (Fuji Visiting Scientist at Tulane University), M. S. Kogutt & A. E. Robinson

  2. Department of Pediatrics, Tulane University Medical Center, New Orleans, LA, USA

    J. H. Humbert

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  1. K. Kaneko
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  2. J. H. Humbert
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  3. M. S. Kogutt
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  4. A. E. Robinson
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Kaneko, K., Humbert, J.H., Kogutt, M.S. et al. Iron deposition in cranial bone marrow with sickle cell disease: MR assessment using a fat suppression technique. Pediatr Radiol 23, 435–438 (1993). https://doi.org/10.1007/BF02012442

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  • DOI: https://doi.org/10.1007/BF02012442

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