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Computer assisted analysis of hand radiographs in infantile hypophosphatasia carriers

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Abstract

Hand radiographs of 49 carriers of infantile hypophosphatasia and 67 non-carriers were evaluated using two Apple IIe Computer Programs and an Apple Graphics Tablet. CAMPS (1) was used to determine the bone lengths and calculate the metacarpophalangeal profiles. A newly developed program (ADAM) was used to determine bone density based on percent cortical area of the second metacarpal. Carriers of infantile hypophosphatasia had significantly less dense bones.

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References

  1. MacPherson RI, Kroeker M, Houston CS (1972) Hypophosphatasia. J Canad Assoc Radiol 23: 16

    PubMed  Google Scholar 

  2. Chodirker BN, Evans JA, Seargeant LE, Cheang MS, Greenberg CR (1990) Hyperphosphatemia in infantile hypophosphatasia: Implications for carrier diagnosis and screening. Am J Hum Genet 46: 280

    PubMed  Google Scholar 

  3. Coupland SG, McLeod DR, Wesenberg RL, Lowry RB (1985) CAMPS: Computer-automated Metacarpophalangeal Profile System. Am J Med Genet 22: 375

    PubMed  Google Scholar 

  4. Poznanski AK (1984) The hand in radiologic diagnosis with gamust and pattern profiles (2nd ed.) WB Saunders, Philadelphia 58

    Google Scholar 

  5. Garn SM, Hertzog K, Poznanski AK, Nagy JM (1972) Metacarpophalangeal length in the evaluation of skeletal malformations. Radiology 105: 375

    PubMed  Google Scholar 

  6. Garn SM Leonard WR, Poznanski AK (1987) Applications of the pattern variability index (σ3) to the quantification of dysmorphogenesis in the hand. Am J Med Genet 27: 143

    PubMed  Google Scholar 

  7. Breslow NE, Day NE (1980) Statistical methods in cancer research. Vol. 1. The analysis of case-control studies. IARC, Lyon, France

    Google Scholar 

  8. Fraser D (1957) Hypophosphatasia. Am J Med 22: 730

    Article  PubMed  Google Scholar 

  9. Eastman JR, Bixler D (1983) Clinical, laboratory and genetic investigations of hypophosphatasia: Support for autosomal dominant inheritance with homozygous lethality. J Craniofacial Dev Biol 3: 213

    Google Scholar 

  10. Chodirker BN, Coburn SP, Seargeant LE, Whyte MP, Greenberg CR (1990) Increased plasma pyridoxal-5′-phosphate levels before and after pyridoxine loading in carriers of perinatal/infantile hypophosphatasia. J Inher Met Dis 13: 891

    Article  Google Scholar 

  11. Smith DW (1982) Recognizable patterns of human malformations. 3rd edn. Saunders, Philadelphia 354–355

    Google Scholar 

  12. Vogel F (1984) Clinical consequences of heterozygosity for autosomal recessive diseases. Clin Genet 25: 381

    PubMed  Google Scholar 

  13. Jandel Scientific Newsletter (1988) vol 2 # 3

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Authors and Affiliations

  1. Department of Pediatrics and Child Health, University of Manitoba, Manitoba, Canada

    B. N. Chodirker, C. R. Greenberg, J. A. Evans & M. H. Reed

  2. Department of Human Genetics, University of Manitoba, Manitoba, Canada

    B. N. Chodirker, C. R. Greenberg & J. A. Evans

  3. Department of Radiology, University of Manitoba, Manitoba, Canada

    M. H. Reed

  4. Community Health Sciences, University on Manitoba, Manitoba, Canada

    M. Cheang & J. A. Evans

  5. Department of Electrical and Computer Engineering, University of Waterloo, Ontario, Canada

    D. Roy

  6. Section of Clinical Genetics, Department of Pediatrics, FE 231-685 William Avenue, R3E 0Z2, Winnipeg, Manitoba, Canada

    B. N. Chodirker

Authors
  1. B. N. Chodirker
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  2. D. Roy
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  3. C. R. Greenberg
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  4. M. Cheang
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  5. J. A. Evans
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  6. M. H. Reed
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Chodirker, B.N., Roy, D., Greenberg, C.R. et al. Computer assisted analysis of hand radiographs in infantile hypophosphatasia carriers. Pediatr Radiol 21, 216–219 (1991). https://doi.org/10.1007/BF02011052

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  • DOI: https://doi.org/10.1007/BF02011052

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