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Intraarticular injection ofPropionibacterium acnes causes an erosive arthritis in rats

  • Models of Inflammation and Arthritis
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Abstract

Formalin killedPropionibacterium acnes, was injected intraarticularly into the stifle joint of rats. The reaction was assessed by radiologic and histologic examination. A single injection induced a marginally erosive synovitis that receded by day 30. A second injection administered in the same joint resulted in tissue destruction that was evident radiographically. Treatment by dexamethasone and some disease modifying drugs, i.e. chloroquine, hydroxychloroquine, sodium aurothiomalate and cyclophosphamide, significantly inhibited cartilage and bone erosion while nonsteroidal antiinflammatory agents had no effect.

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Authors and Affiliations

  1. Syntex Research, Institute of Biological Sciences, 3401 Hillview Avenue, 94304, Palo Alto, CA, USA

    B. S. Trimble, C. J. Evers, S. A. Ballaron & J. M. Young

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  1. B. S. Trimble
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  2. C. J. Evers
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  3. S. A. Ballaron
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  4. J. M. Young
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Trimble, B.S., Evers, C.J., Ballaron, S.A. et al. Intraarticular injection ofPropionibacterium acnes causes an erosive arthritis in rats. Agents and Actions 21, 281–283 (1987). https://doi.org/10.1007/BF01966491

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  • DOI: https://doi.org/10.1007/BF01966491

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