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Comparative activity of the topical quinolone OPC-7251 against bacteria associated with acne vulgaris

  • New Antimicrobial Agents
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Abstract

The antibacterial activity of the topical quinolone OPC-7251 against bacteria commonly found in acne vulgaris was tested in vitro by an agar dilution method. The MIC50 was 0.25 mg/l forPropionibacterium acnes, 0.125 mg/l forPropionibacterium granulosum, 0.03 mg/l forStaphylococcus aureus and 0.06 mg/l for coagulase-negative staphylococci. Compared with seven other antibiotics tested (ciprofloxacin, penicillin, erythromycin, tetracycline, clindamycin, fusidic acid and gentamicin), OPC-7251 had potent activity against both propionibacteria and staphylococci and the lowest incidence of resistant strains.

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Authors and Affiliations

  1. Institute of Medical Microbiology, Free University of Berlin, Hindenburgdamm 27, 1000, Berlin 45, Germany

    K. Vogt & H. Hahn

  2. Department of Dermatology, Division of Mycology and Microbiology, University of Leipzig, Liebigstraße 21, 7010, Leipzig, Germany

    J. Hermann & U. F. Haustein

  3. Department of Dermatology, University Medical Center Steglitz, Free University of Berlin, Hindenburgdamm 30, 1000, Berlin 45, Germany

    U. Blume, H. Gollnick & C. E. Orfanos

Authors
  1. K. Vogt
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  2. J. Hermann
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  3. U. Blume
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  4. H. Gollnick
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  5. H. Hahn
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  6. U. F. Haustein
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  7. C. E. Orfanos
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Vogt, K., Hermann, J., Blume, U. et al. Comparative activity of the topical quinolone OPC-7251 against bacteria associated with acne vulgaris. Eur. J. Clin. Microbiol. Infect. Dis. 11, 943–945 (1992). https://doi.org/10.1007/BF01962381

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  • DOI: https://doi.org/10.1007/BF01962381

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