Skip to main content
Log in

Effect of interleukin 2 on intractable herpes virus infection and chronic eczematoid dermatitis in a patient with Wiskott-Aldrich syndrome

  • Immunology/Allergology
  • Published:
European Journal of Pediatrics Aims and scope Submit manuscript

Abstract

Recombinant interleukin 2 (rIL2) was administered to a patient with Wiskott-Aldrich syndrome for the treatment of an intractabel facial herpetiforme lesion. This treatment appeared to be effective in suppressing the virus activity. At the same time, a transient improvement of the chronic eczematoid dermatitis was observed. During rIL2 administration, the CD3+ and CD4+ subsets of peripheral blood lymphocytes increased in number. These changes might play an important role in the induction of anti-viral immunity and in the improvement of dermatits.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Abbreviations

rIL2:

recombinant Interleukin 2

WAS:

Wiskott-Aldrich syndrome

References

  1. Bich-Thuy LT, Dukovich M, Peter NJ, Fauci AS, Kehrl JH, Green WC (1987) Direct activation of human resting T cells by IL2: the role of an IL2 receptor distinct from the Tac protein. J Immunol 139:1550–1556

    PubMed  Google Scholar 

  2. Chien CH, Hsieh K-H (1990) Interleukin-2 immunotherapy in children. Pediatr 86:937–943

    Google Scholar 

  3. Fisher SJ, Cui TY, Zhang L, Hartman L, Grahl K, Zhang G-Y, Tarpey J, Damsky CH (1989) Adhessive and invasive interaction of human cytotrophoblast cells in vitro. J Cell Biol 109:891–902

    Article  PubMed  Google Scholar 

  4. Grimm EA, Mazumder A, Zhang HZ, Rosenberg SA (1982) Lymphokine-activated killer cell phenomenon: lysis of natural killer-resistant fresh solid tumor cells by interleukin 2-activated autologous human preipheral blood lymphocytes. J Exp Med 155:1823–1841

    PubMed  Google Scholar 

  5. Henney CS, Kuribayashi K, Kern DE, Gillis S (1981) Interleukin-2 augments natural killer cell activity. Nature 291:335–338

    Article  PubMed  Google Scholar 

  6. Miyasaka N, Darnell B, Baron S, Talal N (1984) Interleukin-2 enhances natural killing of normal lymphocytes. Cell Immunol 84:154–162

    Article  PubMed  Google Scholar 

  7. Ochs HD, Slichter SJ, Harker LA, Von Behrens WE, Clark RA, Wedgwiid RJ (1980) The Wiskott-Aldrich syndrome: studies of lymphocytes, granulocytes, and platelets. Blood 55:243–256

    PubMed  Google Scholar 

  8. Pahwa R, Chatila T, Pahwa S, Paradise C, Day NK, Geha R, Schwartz SA, Slade H, Oyaizu N, Good RA (1989) Recombinant interleukin 2 therapy in severe combined immunodeficiency disease. Proc Natl Acad Sci 86:5069–5073

    PubMed  Google Scholar 

  9. Rosenberg SA, Lotze MT, Muul LM, Chnag AE, Avis FP, Leitman S, Linehan WM, Robertson CN, Lee RE, Rubin JT, Seipp CA, Simpson CG, White DE (1987) A progress report on the treatment of 157 patients with advanced cancer using lymphokineactivated killer cells and interleukin-2 or high dose interleukin-2 alone. N Engl J Med 316:889–897

    PubMed  Google Scholar 

  10. Rouse BT, Miller LS, Turtinen L, Moore RN (1985) Augmentation of immunity to herpes simplex virus by in vivo administration of interleukin2. J Immunol 134:926–930

    PubMed  Google Scholar 

  11. Schmid DS (1988) The human MHC-restricted cellular response to herpes simplex virus type 1 is mediated by CD4+, CD8- T cells and is resticted to the DR region of the MHC complex. J Immunol 140:3610–3616

    PubMed  Google Scholar 

  12. Sharon M, Siegel JP, Tosato G, Yodoi J, Gerrard TL, Leonard WJ (1988) The human interleukin 2 receptor chain (P70) Direct identification, partial purification, and patterns of expression on peripheral blood mononuclear cells. J Exp Med 167:1265–1270

    Article  PubMed  Google Scholar 

  13. Siegel JP, Sharon M, Smith PL, Leanard WJ (1987) The IL-2 receptor chain (P70): role in mediating signals for LAK, NK, and proliferative activities. Science 238:75–78

    PubMed  Google Scholar 

  14. Torpey DJ, Lindsley MD, Rinald CR (1989) HLA-restricted lysis of herpes simplex virus-infected monocytes and macrophages mediated by CD4+ and CD8- T lymphocytes. J Immunol 142:1325–1332

    PubMed  Google Scholar 

  15. Trinchieri G, Kobayashi MM, Clark SC, Seehra J, London L, Perussia B (1984) Response of resting human peripheral blood natural killer cells to interleukin 2. J Exp Med 160:1147–1169

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Azuma, H., Sakata, H., Saijyou, M. et al. Effect of interleukin 2 on intractable herpes virus infection and chronic eczematoid dermatitis in a patient with Wiskott-Aldrich syndrome. Eur J Pediatr 152, 998–1000 (1993). https://doi.org/10.1007/BF01957224

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01957224

Key words

Navigation