Summary
Silybin (I), silydianin (II) and silychristin (III), the main constituents of silymarin, inhibit the formation of prostaglandins in vitro. The inhibition is log-linearly dependent on the concentration of the effectors.
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G. Hahn, H.D. Lehmann, M. Kürten, H. Uebel and G. Vogel, Arzneimittel-Forsch.18, 698 (1968). —G. Vogel, W. Trost, R. Braatz, K.P. Odenthal, G. Brüsewitz, H. Antweiler and R. Seeger, Arzneimittel-Forsch.25, 82, 179 (1975). —R. Braatz and C.C. Schneider, eds: Symposium on the Pharmacodynamics of Silymarin. Urban & Schwarzenberg, München-Berlin-Wien 1976.
H. Wagner, P. Diesel and M. Seitz, Arzneimittel-Forsch.24, 466 (1974).
H.M. Rauen, H. Schriewer, U. Tegtbauer and J.F. Lasana, Experientia29, 1372 (1973); Arzneimittel-Forsch.23, 145 (1973). — H. Schriewer and H.M. Rauen, Arzneimittel-Forsch.26, 235 (1976).
A. Bindoli, L. Cavallini and N. Siliprandi, Epatologia23, 219 (1977); Biochem. Pharmac.26, 2405 (1977); Pharmac. Res. Commun.10, 133 (1978).
E. Castigli, I. Mezzasoma, D. Marini and G. Porcellati, Annali Fac. Med. Chir. Univ. Perugia67, 15 (1976). — E. Castigli, I. Montanini, R. Robert and G. Porcellati, Pharmac. Res. Commun.9, 59 (1977). — I. Montanini, E. Castigli, U.G. Arienti and G. Porcellati, Farmaco, ed. sci.32, 141 (1977).
F. Fiebrich and H. Koch, Experientia35, 1548 (1979).
A. Greimel and H. Koch, Experientia33, 1417 1568 (1977). Planta medica32, 323, 331 (1977); Biochem. Physiol. Pflanzen173, 91 (1978).
E.D. Wills, Biochem. J.99, 667 (1966).
J. Robak and B. Sobanska, Biochem. Pharmac.25, 2233 (1976).
M. Hamberg and B. Samuelsson, J. biol. Chem.242, 5336, 5344 (1967); Proc. natl Acad. Sci. USA70, 899 (1973),71, 3400 (1974). —M. Hamberg, J. Svensson, T. Wakabayashi and B. Samuelsson, Proc. natl Acad. Sci. USA71, 345 (1974). —M. Hamberg, J. Svensson and B. Samuelsson, Proc. natl Acad. Sci. USA71, 3824 (1974),72, 2994 (1975). — C. Malmsten, M. Hamberg, J. Svensson and B. Samuelsson, Proc. natl. Acad. Sci. USA72, 1446 (1975).
H. Bekemeier, A.J. Giessler and R. Hirschelmann, Pharmazie29, 671 (1974).
G.P. Lewis and P.J. Piper, Nature254, 308 (1975).
F.A. Kuehl, J.L. Humes, R.W. Egan, E.A. Ham, G.C. Beveridge and C.G. Van Arman, Nature265, 170 (1977).
J.R. Vane, Nature New Biol.231, 232 (1971). — H.J. Robinson and J.R. Vane, eds: Prostaglandin Synthetase Inhibitors. Raven Press, New York 1976.
J.R. Vane, Adv. Prostaglandin Thromboxane Res.2, 791 (1976).
L.H. Rome and W.E.M. Lands, Prostaglandins10, 813 (1975). —M. Hemler, W.E.M. Lands and W.L. Smith, J. biol. Chem.251, 5575 (1976).
J.E. Shaw and P.W. Ramwell, Meth. biochem. Anal.17, 325 (1969).
We acknowledge the gift of the test compounds by Dr K. Görler from Dr. Madaus & Co., Cologne.
H.C. Kiefer, C.R. Johnson and K.L. Arora, Analyt. Biochem.68, 336 (1975); Z. analyt. Chem.279, 336 (1976).
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F. Fiebrich, Thesis, University of Vienna 1977.
H. Koch, Dt. ApothZtg118, 1844 (1978); reported in part at the Colloquium Pharmaceuticum in Münster, 21st November 1978.
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Fiebrich, F., Koch, H. Silymarin, an inhibitor of prostaglandin synthetase. Experientia 35, 1550–1552 (1979). https://doi.org/10.1007/BF01953185
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DOI: https://doi.org/10.1007/BF01953185