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Suitability of urethane anesthesia for physiopharmacological investigations in various systems. Part 2: Cardiovascular system

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Summary

Urethane produces a level of surgical anesthesia characterized by preservation of a number of cardiovascular reflexes. When the proper route of administration is used, and the use of unnecessarily high doses is avoided, urethane anesthesia appears to be suitable for a number of investigations at cardiovascular level. However in certain types of studies involving pharmacological stimulation of peripheral adrenoceptors urethane affects markedly the magnitude of the response under study.

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  1. Pharmacology Department, Research Laboratories, A. Menarini Pharmaceuticals, Via Sette Santi 3, I-50131, Florence, Italy

    C. A. Maggi & A. Meli

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  1. C. A. Maggi
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  2. A. Meli
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Maggi, C.A., Meli, A. Suitability of urethane anesthesia for physiopharmacological investigations in various systems. Part 2: Cardiovascular system. Experientia 42, 292–297 (1986). https://doi.org/10.1007/BF01942510

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