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Plasma levels of IL-1, TNF alpha, IL-6, IL-8, G-CSF, and IL1-RA during febrile neutropenia: Results of a prospective study in patients undergoing chemotherapy for acute myelogenous leukemia

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Abstract

Plasma levels of IL-1, IL-6, IL-8, IL1-RA, TNF alpha, and G-CSF were prospectively studied during 23 chemotherapy cycles of 20 patients suffering from acute myelogenous leukemia. Increased plasma levels of IL-6, IL-8, and G-CSF were observed in patients with febrile neutropenia and/or major infection. Plasma levels of IL-6, IL-1, TNF alpha and IL-1-RA measured 1 day before and 1 day after the onset of febrile episodes did not accurately predict the development of major infection. In contrast, IL-8 plasma levels were significantly higher in those patients who subsequently developed major infection. The question whether IL-8 plasma levels identify high risk or low risk patients with sufficient specificity and sensitivity has to be answered in large scale clinical trials.

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Authors and Affiliations

  1. Department of Microbiology, Division of Hematology, Third Department of Internal Medicine, University Hospital Mainz, Langenbeckstrasse 1, D-55131, Mainz, Germany

    H. Schönbohn, M. Schuler, K. Kolbe, C. Peschel, C. Huber, W. Bemb & W. E. Aulitzky

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  1. H. Schönbohn
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  2. M. Schuler
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  3. K. Kolbe
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  4. C. Peschel
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  5. C. Huber
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  6. W. Bemb
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  7. W. E. Aulitzky
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This work was performed as thesis of H. Schönbohn

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Schönbohn, H., Schuler, M., Kolbe, K. et al. Plasma levels of IL-1, TNF alpha, IL-6, IL-8, G-CSF, and IL1-RA during febrile neutropenia: Results of a prospective study in patients undergoing chemotherapy for acute myelogenous leukemia. Ann Hematol 71, 161–168 (1995). https://doi.org/10.1007/BF01910312

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  • DOI: https://doi.org/10.1007/BF01910312

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