Summary
Left ventricular hypertrophy was induced by banding of the ascending aorta in puppies at the age of 6 weeks. At the age of one year left ventricular weight per body weight was increased by 87% compared to control litter mates. While myocardial perfusion and myocardial oxygen consumption per 100 g were identical in the hypertrophy and control group, there was a significantly diminished ratio of subendocardial/subepicardial flow in the hypertrophy group during moderate exercise. With maximal coronary dilation subendocardial diastolic resistance (mm Hg/ml·min−1 per 100 g) was 0.16±0.03 in the control group and 0.26±0.03 in the hypertrophy group. This diminished coronary reserve indicates an insufficient growth of the vascular bed in these hypertrophied hearts.
Zusammenfassung
Jungen Hunden im Alter von 6 Wochen wurde ein Ring um die Aorta ascendens gelegt. Dadurch wurde eine Hypertrophie des linken Ventrikels induziert, so daß im Alter von einem Jahr das Gewichtsverhältnis des linken Ventrikels pro Körpergewicht um 87% höher war als in normalen Wurfgeschwistern. Während die Myokardperfusion und der myokardiale Sauerstoffverbrauch pro 100 g in der normalen Gruppe und in der Gruppe mit Hypertrophie identisch waren, ergab sich bei Arbeit ein signifikant erniedrigtes Verhältnis der subendokardialen Druchblutung zur subepikardialen Durchblutung in den Hunden mit hypertrophierten Herzen. Bei maximaler Koronardilatation betrug der subendokardialen Durchblutung zur subepikardialen Durchblutung in den Hunden in normalen Hunden und 0,26±0,03 in Hunden mit Herzhypertrophie. Diese verminderte Koronarreserve spricht für ein nicht ausreichendes Wachstum des Koronargefäßbettes in diesen hypertrophierten Herzen.
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Holtz, J., v. Restorff, W., Bard, P. et al. Transmural distribution of myocardial blood flow and of coronary reserve in canine left ventricular hypertrophy. Basic Res Cardiol 72, 286–292 (1977). https://doi.org/10.1007/BF01906375
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DOI: https://doi.org/10.1007/BF01906375