Skip to main content
Log in

Contribution of CT to characterization of focal nodular hyperplasia of the liver

  • Published:
Gastrointestinal Radiology Aims and scope Submit manuscript

Abstract

Our personal series of 20 cases of focal nodular hyperplasia (FNH) of the liver is presented. All lesions were studied with computed tomography (CT), 16 of which with surgical control. Retrospective evaluation of the CT features of the identified FNH, along with those of five hepatocellular adenomas (HCA) and 30 hepatocellular carcinomas (HCC), allowed the definition of specific patterns leading to a correct characterization of FNH in 78% of cases. This greatly reduced the diagnostic errors, with the sole exception of patients with fatty liver in whom nuclear medicine may eventually provide a correct characterization. Fine-needle biopsy is thus only necessary in the dubious cases. A precise diagnostic workup of FNH is necessary, since it may avoid the surgical intervention.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Edmonson HA. Tumors of the liver and intrahepatic bile ducts. In:Atlas of tumors. Pathology section. Washington, D.C.: AFIP, 1958:25

    Google Scholar 

  2. Ishak KG, Rabin L. Benign tumors of the liver.Med Clin North Am 1975;59:995–1013

    PubMed  Google Scholar 

  3. Kerlin P, Davis GL, McGill DB, Weiland LH, Adson MA, Sheedy PF II. Hepatic adenoma and focal nodular hyperplasia: clinical, pathologic and radiologic features.Gastroenterology 1983;84:994–1002

    Google Scholar 

  4. Knowles DM, Casarella WJ, Johnson PM, Wolff M. The clinical, radiologic and pathologic characterization of benign hepatic neoplasm. Alleged association with oral contraceptives.Medicine 1978;57:223–237

    PubMed  Google Scholar 

  5. Mangiante G, Pistacchi E, Marchiori L, Nicoli N, Dagradi A. Hepatocellular adenoma and focal nodular hyperplasia.Chir Ital 1989;41:117–128

    PubMed  Google Scholar 

  6. Nichols FC, Van Heerden JA, Weiland LH. Benign liver tumors.Surg Clin North Am 1989;69:297–314

    PubMed  Google Scholar 

  7. Mathieu D, Bruneton JN, Drouillard J, Pointreau CC, Vasile N. Hepatic adenoma and focal nodular hyperplasia: dynamic CT study.Radiology 1986;160:53–58

    PubMed  Google Scholar 

  8. Nokes SR, Baker ME, Spritzer CE, Meyers W, Herfkens RJ. Hepatic adenoma: MR appearance mimicking focal nodular hyperplasia.JCAT 1988;12:885–887

    Google Scholar 

  9. Rummeny E, Weissleder R, Sironi S, Stark DD, Compton CC, Hahn PF, Saini S, Wittenberg J, Ferrucci JT. Central scar in primary liver tumors: MR features, specificity and pathologic correlation.Radiology 1989;171:323–326

    PubMed  Google Scholar 

  10. Titelbaum DS, Burke DR, Meranze SG, Saul SH. Fibrolamellar hepatocellular carcinoma: pitfalls in nonoperative diagnosis.Radiology 1988;167:25–30

    PubMed  Google Scholar 

  11. Huguet C, Nordlinger B, Baron JC, Parc R, Tubiana JM, Loygue J. Kystes congenitaux et tumeurs benignes du foie de l'adulte. Quelles indications chirurgicales? A propos de quarante-sept cas.Ann Chir 1986;40:231–235

    PubMed  Google Scholar 

  12. Rogers JV, Mack LA, Freeny PC, Johnson ML, Sones PJ. Hepatic focal nodular hyperplasia: angiography, CT, sonography, and scintigraphy.AJR 1987;137:983–990

    Google Scholar 

  13. Ruschenburg I, Droese M. Fine needle aspiration cytology of focal nodular hyperplasia of the liver.Acta Cytol 1989;33:857–860

    PubMed  Google Scholar 

  14. Klatskin J. Hepatic tumors: possible relationship to use of oral contraceptives.Gastroenterology 1977;73:386–394

    PubMed  Google Scholar 

  15. D'Souza VJ, Sumner TE, Watson NE, Formanek AG. Focal nodular hyperplasia of the liver imaging by differing modalities.Pediatr Radiol 1983;13:77–81

    PubMed  Google Scholar 

  16. Freeny PC. Radiologic diagnosis of hepatic neoplasms.Postgrad Radiol 1990;10:263–283

    Google Scholar 

  17. Biersak HJ, Thelen M, Torres JF, Lackner K, Winkler CG. Focal nodular hyperplasia of the liver as established by Tc 99m sulfur colloid and HIDA scintigraphy.Radiology 1980;137:187–190

    PubMed  Google Scholar 

  18. Marabini A, Giorgetti PG, Zamboni M, Cavaggioni M, Braggio P, Nicoli N, Mangiante G. Nuclear medicine identification of hepatic focal nodular hyperplasia: experience of 10 cases.J Nucl Med Allied Sci 1989;33:154

    Google Scholar 

  19. Ros PR, Li KCP. Radiology of malignant and benign liver tumors. Part II: benign liver tumors.Curr Probl Diagn Radiol 1989;18:125–155

    PubMed  Google Scholar 

  20. Welch TJ, Sheedy PF, Johnson CM, Stephens DH, Charboneau JW, Brown ML, May GR, Adson MA, McGill DB. Focal nodular hyperplasia and hepatic adenoma: comparison of angiography, CT, US, and scintigraphy.Radiology 1985;156:593–595

    PubMed  Google Scholar 

  21. Calvet X, Pons F, Bruix J, Bru C, Lomena F, Herranz R, Brugera M, Faus R, Rodes J. Technetium-99m DISIDA hepatobiliary agent in diagnosis of hepatocellular carcinoma: relationship between detectability and tumor differentiation.J Nucl Med 1988;29:1916–1920

    PubMed  Google Scholar 

  22. Drane WE, Krasicky GA, Johnson DA. Radionuclide imaging of primary tumors and tumor-like conditions of the liver.Clin Nucl Med 1987;12:569–582

    PubMed  Google Scholar 

  23. Savitch I, Kew MC, Paterson A, Esser JD, Levin J. Uptake of Tc-99m-Di-isopropyliminodiacetic acid by hepatocellular carcinoma: concise communication.J Nucl Med 1983;24:1119–1122

    PubMed  Google Scholar 

  24. Lubbers PR, Ros PR, Goodman ZD, Ishak KG. Accumulation of technetium-99m sulfur colloid by hepatocellular adenoma: scintigraphic-pathologic correlation.AJR 1987;148:1105–1108

    PubMed  Google Scholar 

  25. Vincent LM, Rho TH, McCartney WH, Mauro MA. Hepatic adenoma. Demonstration of discordant uptake with Tc-99m sulfur colloid and Tc-99m DISIDA.Clin Nucl Med 1984;9:415–416

    PubMed  Google Scholar 

  26. Freeny PC, Marks WM. Hepatic hemangioma: dynamic bolus CT.AJR 1986;147:711–719

    PubMed  Google Scholar 

  27. Freeny PC, Marks WM. Patterns of contrast enhancement of benign and malignant hepatic neoplasms during bolus dynamic and delayed CT.Radiology 1986;160:613–618

    PubMed  Google Scholar 

  28. Itai Y, Ohtomo K, Kokubo T, Yamauchi T, Minami M, Yashiro N, Araki T. CT of hepatic masses: significance of prolonged and delayed enhancement.AJR 1986;146:729–733

    PubMed  Google Scholar 

  29. Lewis E, Bernardino ME, Barnes PA, Parvey HR, Soo CS, Chuang VP. The fatty liver: pitfalls in the CT and angiographic evaluation of metastatic disease.JCAT 1983;7:235–241

    Google Scholar 

  30. Casarella WJ, Knowles DM, Wolff M, Johnson PM. Focal nodular hyperplasia and liver cell adenoma: radiologic and pathologic differentiation.AJR 1978;131:393–402

    PubMed  Google Scholar 

  31. Bedi DG, Kumar R, Morettin LB, Gourley K. Fibrolamellar carcinoma of the liver: CT, ultrasound and angiography.Europ J Radiol 1988;8:109–112

    Google Scholar 

  32. Brandt DJ, Johnson CD, Stephens DH, Weiland LH. Imaging of fibrolamellar hepatocellular carcinoma.AJR 1988;151:295–299

    PubMed  Google Scholar 

  33. Kane RA, Curatolo P, Khettry U. “Scar sign” on computed tomography and sonography in fibrolamellar hepatocellular carcinoma.J Comput Tomogr 1987;11:27–30

    PubMed  Google Scholar 

  34. Saul SH, Titelbaum DS, Gansler TS, Varello M, Burke DR, Atkinson BF, Rosato EF. The fibrolamellar variant of hepatocellular carcinoma. Its association with focal nodular hyperplasia.Cancer 1987;60:3049–3055

    PubMed  Google Scholar 

  35. Schiebler ML. Hepatocellular carcinoma: MR appearance mimicking focal nodular hyperplasia.AJR 1988;150:472

    Google Scholar 

  36. Huebener KH, Treught H. Administration of biliary contrast media in computed tomography. In: Felix R et al, eds.Contrast media in computed tomography. Proceedings of the international workshop, Berlin 1981. Amsterdam: Excerpta Medica, 1981:46–51

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Procacci, C., Fugazzola, C., Cinquino, M. et al. Contribution of CT to characterization of focal nodular hyperplasia of the liver. Gastrointest Radiol 17, 63–73 (1992). https://doi.org/10.1007/BF01888511

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01888511

Key words

Navigation