Skip to main content

Advertisement

SpringerLink
Log in

Long-term follow-up results of 175 patients with malignant glioma: Importance of radical tumour resection and postoperative adjuvant therapy with interferon, ACNU and radiation

  • Clinical Articles
  • Published:
Acta Neurochirurgica Aims and scope Submit manuscript

Summary

We analysed long-term follow-up results of 175 patients with malignant glioma (110 glioblastoma and 65 anaplastic astrocytoma) treated under five different regimes during the past two decades. The factors of age (less than 40), histology (anaplastic astrocytoma) and type of adjuvant therapy (radiation and chemotherapy) contributed to long survival. The other important factor was the response to adjuvant therapy.

Cases of gross total removal or complete response (CR) of a residual tumour to an adjuvant therapy showed a better prognosis. The three and five year survival rate was 42% and 24%, respectively. The highest CR ratio (23%) was seen in patients treated by intravenous injection of interferon and ACNU in addition to radiotherapy (IAR therapy).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Akslen LA, Mork SJ, Larsen JL Myrseth E (1988) Giant cell glioblastoma: a work-up of 2 cases with long survival. Acta Neurol Scan 79: 194–199

    Google Scholar 

  2. Ammirati M, Vick N, Liao Y, Ciric I, Mikhael M (1987) Effect of extent of surgical resection on survival and quality of life in patients with supratentorial glioblastoma and anaplastic astrocytomas. Neurosurgery 21: 201–206

    PubMed  Google Scholar 

  3. Burger PC, Green SB (1987) Patient age, histologic features, and length of survival in patients with glioblastoma multiforme. Cancer 59: 1617–1625

    PubMed  Google Scholar 

  4. Gresser I, Maury C, Brouthy-boye' D (1972) Mechanism of the antitumor effect of interferon in mice. Nature 239: 167–168

    PubMed  Google Scholar 

  5. Kent DL, Larson EB (1988) Magnetic resonance imaging of the brain and spine is clinical efficacy established after the first decade. Ann Intern Med 107: 402–424

    Google Scholar 

  6. Mizuno M, Yoshida J, Sugita K, Inoue I, Seo H, Hayashi Y, Koshizaka T, Yagi K (1990) Growth inhibition of glioma cells transfected with human β-interferon gene by liposomes coupled with a monoclonal antibody. Cacer Res 50: 7826–7829

    Google Scholar 

  7. Nagai M, Asai T (1984) Clinical effect of interferon in malignant brain tumors. Neurosurg Rev 7: 55–64

    PubMed  Google Scholar 

  8. Ruts HP, De Tribolet N, Calmes JM, Chapuis G (1991) Longtime survival of a patient with glioblastoma and Turcot's syndrome. J Neurosurg 74: 813–815

    PubMed  Google Scholar 

  9. Shapiro WR, Green SB, Burger PC, Mahaley S, Selker RG, Vangilder JC, Robertson JT, Ransohof J, Mealey J, Strike TA, Pistenmaa DA (1989) Randomized trial of three chemotherapy regimens and two radiotherapy regimens in post operative treatment of malignant glioma. Brain tumor Coop Group Trial 8001. J Neurosurg 191: 1–9

    Google Scholar 

  10. Takakura S, Abe H, Kitamura K, Kitamura K, Miwa T, Takenchi K, Yamamoto S, Kageyama N, Handa H, Mogami H, Nishimoto A, Uozumi T, Matsutani M, Nomura K (1986) Effect of ACNU and radiotherapy on malignant glioma. J Neurosurg 64: 53–57

    PubMed  Google Scholar 

  11. Takeuchi K, Hoshino K (1977) Statistical analysis of factors affecting survival after glioblastoma multiforme. Acta Neurochir (Wien) 37: 57–73

    Google Scholar 

  12. Tashiro T, Yoshida J, Mizuno M, Sugita K (1993) Reinforced cytotoxicity of lymphokine-activated killer cells toward glioma cells by transfection with the tumour necrosis factor-α gene. J Neurosurg 78: 252–256

    PubMed  Google Scholar 

  13. Yamamoto SH, Tanaka H, Kanamori M, Nobuhara M, Namba M (1983) In vitro studies on potentiation of cytotoxic effects of anticancer drugs by interferon on a human neoplastic cell line (HeLa). Cancer 20: 131–138

    Google Scholar 

  14. Yoshida J, Kato K, Wakabayashi T, Enomoto H, Inoue I, Kageyama N (1986) Antitumor activity of interferon-β against malignant glioma in combination with chemotherapeutic agent of nitrosoureas (ACNU). In: Cantell Ket al (eds) The biology of the interferon system 1986. Martinus Nyhoff Netherlands, pp 399–406

    Google Scholar 

  15. Yoshida J, Yamamoto R, Wakabayashi T, Nagata M, Seo H (1990) Radioimmunoassay of glioma-associated antigen in cerebrospinal fluid and its usefulness for the diagnosis and monitoring of human glioma. J Neurooncol 8: 23–31

    PubMed  Google Scholar 

  16. Yoshida J, Mizuno M, Yagi K (1991) Secretion of human β-interferon into the cystic fluid of glioma transfected with the interferon gene. J Clin Biochem Nutr 11: 123–128

    Google Scholar 

  17. Yoshida J, Mizuno M, Yagi K (1992) Cytotoxicity of human β-interferon produced in human glioma cells transfected with its gene by means of liposomes. Biochem Inten 28: 1055–1061

    Google Scholar 

  18. Walker MD, Green SB, Byar DP, Alexander E, Batzdorf U, Brook WH, Hunt WE, Maccarty CS, Mahalry MS, Mealey J, Owens G, Ransohoff J, Robertson JT, Shapiro WR, Smith KR, Wilson CB, Strike TA (1980) Randomized comparison of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery. N Engl J Med 303: 1223–1329

    Google Scholar 

  19. Weir B (1973) The relative significance of factors affecting postoperative survival in astrocytomas, grade 3 and 4. J Neurosurg 38: 448–452

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurosurgery, Nagoya University School of Medicine, Nagoya, Japan

    J. Yoshida, Y. Kajita, T. Wakabayashi & K. Sugita

Authors
  1. J. Yoshida
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Y. Kajita
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. T. Wakabayashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. K. Sugita
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yoshida, J., Kajita, Y., Wakabayashi, T. et al. Long-term follow-up results of 175 patients with malignant glioma: Importance of radical tumour resection and postoperative adjuvant therapy with interferon, ACNU and radiation. Acta neurochir 127, 55–59 (1994). https://doi.org/10.1007/BF01808547

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01808547

Keywords

Search

Navigation