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Interactions between cancer cells and the microvasculature: a rate-regulator for metastasis

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Abstract

Hematogenous metastasis is a major consideration in the staging, treatment and prognosis of patients with cancer. Key events affecting hematogeneous metastasis occur in the microvasculature. This is a brief, selective review of some interactions involving cancer cells and the microvasculature in pathologic sequence, specifically: (1) intravasation of cancer cells; (2) the arrest of circulating cancer cells in the microvasculature; (3) cancer cell trauma associated with arrest; (4) microvascular trauma; (5) the inflammatory; and (6) the hemostatic coagulative responses associated with arrest, and finally (7) angiogenesis, leading to tumor vascularization. The evidence shows that through a series of complex interactions with cancer cells, the microvasculature acts as a rate-regulator for the metastatic process, in addition to providing routes for cancer cell dissemination and arrest sites for cancer cell emboli.

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Authors and Affiliations

  1. Department of Experimental Pathology, Roswell Park, Memorial Institute, 4263, Buffalo, NY, USA

    Leonard Weiss

  2. Department of Pathology, McMaster University, L8N 3Z5, Hamilton, Ontario, Canada

    F. William Orr

  3. Department of Radiation Oncology, Wayne State University, 48202, Detroit, MI, USA

    Kenneth V. Honn

  4. Gershenson Radiation Oncology Center, Harper/Grace Hospitals, 48202, Detroit, MI, USA

    Kenneth V. Honn

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  1. Leonard Weiss
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Weiss, L., Orr, F.W. & Honn, K.V. Interactions between cancer cells and the microvasculature: a rate-regulator for metastasis. Clin Exp Metast 7, 127–167 (1989). https://doi.org/10.1007/BF01787020

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