Abstract
31P-containing metabolites in human blood, serum and erythrocytes were measured or calculated. Phosphodiesters were found in serum, but not in erythrocytes. 2,3-diphosphoglycerate and 2,3-diphosphoglycerate/ATP ratios were increased in patients with congestive heart failure (2,3-diphosphoglycerate by 13% in mild to moderate, 31% in severe congestive heart failure, 2,3-diphosphoglycerate/ATP ratio by 9% in mild to moderate, 38% in severe congestive heart failure); phosphodiesters were increased in diabetes mellitus (by 26%) and even more so in hyperlipidaemia (by 57%). Changes of blood31P compounds with disease states may have diagnostic potential and should be recognized for correction of organ spectra.
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Horn, M., Neubauer, S., Bomhard, M. et al. 31P-NMR spectroscopy of human blood and serum: first results from volunteers and patients with congestive heart failure, diabetes mellitus and hyperlipidaemia. MAGMA 1, 55–60 (1993). https://doi.org/10.1007/BF01760400
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DOI: https://doi.org/10.1007/BF01760400