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Physiologie und Biochemie der Knochenbildung

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Zusammenfassung

Die heutige Auffassung der physiologischen und biochemischen Vorgänge bei der Knochenbildung wurden kurz dargelegt. Der Aufbau und die Struktur der drei Hauptbestandteile des Knochens, die Zellen, das organische Stroma und das Mineral, wurde besprochen. Insbesondere ist auf die Differenzierungsvorgänge in Osteoblasten, welche die Synthese der Kollagenfasern und der Grundsubstanz vollziehen und auf den Mechanismus der Calciumphosphatablagerung eingegangen worden.

Summary

Current concepts of the physiology and biochemistry of bone formation have been briefly reviewed. The synthesis and the structure of the three basic parts of bone, cells, organic matrix and mineral are described. After differentiation the osteoblasts synthesize the collagen fibers and the mucoproteins of the organic matrix. This organic matrix is probably involved in the regulation of calcium phosphate deposition, although the mechanism is still poorly understood. Other factors influencing mineralization are discussed.

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    H. Fleisch

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Fleisch, H. Physiologie und Biochemie der Knochenbildung. Klin Wochenschr 44, 360–363 (1966). https://doi.org/10.1007/BF01745924

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