Summary
Plasma total cholesterol (TC), triglycerides (TG), high-density lipoprotein-cholesterol (HDL-C), and low-density lipoprotein-cholesterol (LDL-C) were studied in 15 hyperprolactinemic women who had a prolactin (PRL) adenoma, in comparison to 15 age-matched control women. In the hyperprolactinemic group, plasma lipids were also correlated to age, excess body weight (EBW), plasma PRL, and estradiol-17β (E2). Plasma TC, TG, and LDL-C were similar in both hyperprolactinemic and control women, while plasma HDL-C was significantly lower (P<0.01) in the hyperprolactinemic group. The correlation study showed a significant negative correlation between HDL-C and EBW (r=−0.64;P<0.02) and a slightly significant positive correlation between TG and PRL (r=0.54;P<0.05). The direct effect of PRL on plasma lipids is difficult to establish since many factors influencing lipid metabolism are altered during hyperprolactinemia.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Abbreviations
- EBW:
-
excess body weight
- E2:
-
estradiol-17β
- GH:
-
growth hormone
- HDL-C:
-
high-density lipoprotein-cholesterol
- LDL-C:
-
low-density lipoprotein-cholesterol
- LPL:
-
lipoprotein lipase
- PRL:
-
prolactin
- RIA:
-
radioimmunoassay
- TC:
-
total cholesterol
- TG:
-
triglycerides
References
Bartke A (1971) Effects of prolactin and luteinizing hormone on the cholesterol stores in the mouse testis. J Endocrinol 49:317–324
Briones ER, Mao SJT, Palumbo PJ, O'Fallon WM, Chenoweth W, Kottke BA (1984) Analysis of plasma lipids and apolipoproteins in insulin-dependent and noninsulin-dependent diabetics. Metabolism 33:42–49
Cameron CM, Linebaugh BE, Rillema A (1983) Hormonal control of lipid metabolism in mouse mammary gland explants. Endocrinology 112:1007–1011
Friedman CI, Falko JM, Patel ST, Kim MH, Newman HAI, Barrows H (1982) Serum lipoprotein responses during active and stable weight reduction in reproductive obese females. J Clin Endocrinol Metab 55:258–262
Gennes JL de, Dairou F, Truffert J (1981) Double screening test at 8th and 12th hour of overnight fasting for a better classification of idiopathic hyperlipidemias. Large scale study of 505 tests. Diabete Metab 7:161–167
Gennes JL de, Turpin G, Heshmati HM, Lebrun A (1979) Carence en somathormone: effet protecteur contre le développement de l'athérosclérose. A propos de 12 observations associant hypopituitarisme et hyperlipidémie. Nouv Presse Med 8:3877–3880
Gustafson AB, Banasiak MF, Kalkhoff RK, Hagen TC, Kim HJ (1980) Correlation of hyperprolactinemia with altered plasma insulin and glucagon: similarity to effects of late human pregnancy. J Clin Endocrinol Metab 51:242–246
Hazzard WR, Haffner SM, Kushwaha RS, Applebaum-Bowden D, Foster DM (1984) Preliminary report: kinetic studies on the modulation of high-density lipoprotein, apolipoprotein, and subfraction metabolism by sex steroids in a postmenopausal woman. Metabolism 33:779–784
Horseman ND, Meier AH (1979) Circadian phase-dependent prolactin mechanisms in hepatic lipogenèsis of a teleost. J Endocrinol 82:367–372
Johnston DG, Alberti KGMM, Nattrass M, Burrin JM, Blesa-Malpica G, Hall K, Hall R (1980) Hyperinsulinaemia in hyperprolactinaemic women. Clin Endocrinol (Oxf) 13:361–368
Jungmann E, Althoff PH, Hermann GJ, Schöffling K (1985) Evidence for functional impairment of growth hormone secretion in prolactinoma. In: Auer LM, Leb G, Tscherne G, Urdl W, Walter GF (eds) Prolactinomas: an interdisciplinary approach. Walter de Gruyter, Berlin, pp 147–153
Klibanski A, Neer RM, Beitins IZ, Ridgway EC, Zervas NT, McArthur JW (1980) Decreased bone density in hyperprolactinemic women. N Engl J Med 303:1511–1514
Mann GV (1974) The influence of obesity on health. N Engl J Med 291:226–232
Marcovitz S, Goodyer CG, Guyda H, Gardiner RJ, Hardy J (1982) Comparative study of human fetal, normal adult, and somatotropic adenoma pituitary function in tissue culture. J Clin Endocrinol Metab 54:6–16
Meier AH (1977) Daily rhythms of lipogenesis in fat and lean white-throated sparrowsZonotrichia albicollis. Am J Physiol 232:E193-E196
Pelkonen R, Nikkilä EA, Grahne B (1982) Serum lipids, postheparin plasma lipase activities and glucose tolerance in patients with prolactinoma. Clin Endocrinol (Oxf) 16:383–390
Sitruk-Ware LR, Sterkers N, Mowszowicz I, Mauvais-Jarvis P (1977) Inadequate corpus luteal function in women with benign breast diseases. J Clin Endocrinol Metab 44:771–774
Snyder JM, Longmuir KJ, Johnston JM, Mendelson CR (1983) Hormonal regulation of the synthesis of lamellar body phosphatidylglycerol and phosphatidylinositol in fetal lung tissue. Endocrinology 112:1012–1018
Vis-Melsen MJE van der, Wiener JD (1973) Effect of thyrotrophin-releasing hormone on serum cholesterol. Br Med J 4:419
Wallentin L, Larsson-Cohn U (1977) Metabolic and hormonal effects of post-menopausal oestrogen replacement treatment. II. Plasma lipids. Acta Endocrinol (Copenh) 86:597–607
Winter RJ, Green OC (1984) Effect of thyroxine and growth hormone on the hypercholesterolemia of growth hormone deficiency. Metabolism 33:54–57
Winter RJ, Thompson RG, Green OC (1979) Serum cholesterol and triglycerides in children with growth hormone deficiency. Metabolism 28:1244–1249
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Heshmati, H.M., Turpin, G. & de Gennes, J.L. Chronic hyperprolactinemia and plasma lipids in women. Klin Wochenschr 65, 516–519 (1987). https://doi.org/10.1007/BF01721038
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01721038