Summary
The steady-state formation of prooxidants in cells and organs is balanced by a similar rate of their consumption by antioxidants that are enzymatic and/or nonenzymatic. “Oxidative stress” results from imbalance in this prooxidantantioxidant equilibrium in favor of the prooxidants. A number of diseases are associated with oxidative stress, being the basis of a potential antioxidant therapy. However, current evidence in clinical research does not show unequivocal distinction between causal or associative relationships of prooxidants to the disease process.
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Abbreviations
- ARDS:
-
adult respiratory distress syndrome
- EDRF:
-
endothelium-derived relaxing factor
- MOF:
-
multi-or-gan failure
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Manuscripts published in this issue were the matter of a Symposium held at the University of Ulm, April 24–27, 1991
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Sies, H. Role of reactive oxygen species in biological processes. Klin Wochenschr 69, 965–968 (1991). https://doi.org/10.1007/BF01645140
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DOI: https://doi.org/10.1007/BF01645140