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The effect of high sodium intake on bone mineral content in rats fed a normal calcium or a low calcium diet

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Abstract

The effect of high sodium intake on bone mineral content of rats fed a normal (0.6% Ca) or a low (0.02% Ca) calcium diet was studied. Rats on a normal calcium diet given 1.8% sodium chloride to drink showed persistent and significant hypercalciuria and subnormal bone mineral content. Total calcium content of femur was significantly lower after 4 months (p<0.02) and 12 months (p<0.001). In rats maintained on a low calcium diet (0.02% Ca), a high sodium diet for 8 weeks caused a significant loss of calcium in bone similar to that seen in animals fed a normal calcium diet for 4 months. We conclude that high sodium intake reduces bone mineral content, especially if the diet is low in calcium.

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Authors and Affiliations

  1. Department of Chemical Pathology, The Prince of Wales Hospital, Shatin NT, Hong Kong

    A. Y. S. Chan, E. L. P. Chan & S. L. M. Fung

  2. Department of Clinical Biochemistry, 5th Floor: Tower, Guy's Hospital, St Thomas' Street, SE1 9RT, London, UK

    P. Poon &  R. Swaminathan

Authors
  1. A. Y. S. Chan
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  2. P. Poon
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  3. E. L. P. Chan
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  4. S. L. M. Fung
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  5. R. Swaminathan
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Chan, A.Y.S., Poon, P., Chan, E.L.P. et al. The effect of high sodium intake on bone mineral content in rats fed a normal calcium or a low calcium diet. Osteoporosis Int 3, 341–344 (1993). https://doi.org/10.1007/BF01637321

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  • DOI: https://doi.org/10.1007/BF01637321

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