Abstract
Vertebral trabecular bone mineral density (BMD) was measured in 187 healthy Icelandic women, age 35–64 years, by quantitative computed tomography (QCT) with the use of internal references (muscle and subcutaneous fat) instead of the traditional external references (phantoms). We found a mean 2.4 mg/cm3 (1.8%) bone loss per year in the age range 35–64 years. There was an accelerated phase (exponential) after menopause, with 4% loss per year for the first 1–5 years after menopause or 5-fold trabecular bone loss compared with the subsequent 11–15 years after menopause. Reproducibility was found to be 1.9%. This method thus compares with traditional QCT measurements and is highly reproducible. We find QCT using internal references a promising method for assessing fracture risk in perimenopausal women and for follow-up in osteoporotic patients.
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Holland EA, Rogers LF. Osteoporosis: impact on the elderly, societal concerns, and the role of radiology. Curr Probl Diagn Radiol 1989;18:44–61.
Genant HK, Block JE, Steiger P, Glueer CC, Ettinger B, Harris ST. Appropriate use of bone densitometry. Radiology 1989;170:817–22.
Ross PD, Davis JW, Vogel JM, Wasnich RD. A critical review of bone mass and the risk of factures in osteoporosis. Calcif Tissue Int 1990;46:149–61.
Genant HK, Block JE, Steiger P, Glueer CC, Smith R. Quantitative computed tomography in assessment of osteoporosis. Semin Nucl Med 1987;17:316–33.
Cann CE, Genant HK, Kolb FO, Ettinger B. Quantitative computed tomography for prediction of vertebral fracture risk. Bone 1985;6:1–7.
Boden SD. Goodenough DJ. Stockham CD, Jacobs E, Dina T, Allman RM. Precise measurement of vertebral bone density using computed tomography without the use of an external reference phantom. J Digital Imaging 1989;2:31–8.
Steingrimsdottir L, Thorgeirsdóttir H, Aegisdottir S. Könnuná matarædi Íslendinga. (Nutritional survey in Iceland). Rannsoknir Manneldisrads Islands III, 1990;90
White DR, Tissue substitutes in experimental radiation physics. Med Phys 1987;5:467–79.
Dixon WJ (ed). BMDP statistical software manual. San Francisco: University of California Press, 1990.
Shrimpton PC, Jones DG, Hillier MC, Wall BF. Le Heron JC, Faulkner K. Survey of CT practice in the UK. II. Dosimetric aspects. National Radiological Protection Board, NRPB-R249, 1991.
Arnold BA. Works in progress: histogram analysis and ROI of pac-man shape. Osteo-Update 1987;1:6–7.
Krølner B, Pors Nielsen S. Bone mineral content of the lumbar spine in normal and osteoporotic women: cross-sectional and longitudinal studies. Med Sci 1982;62:329–36.
Firooznia H, Golimbu C, Rafii M, Schwartz MS, Alterman ER. Quantitative computed tomography assessment of spinal trabecular bone. I. Age-related regression in normal men and women. J Comput Tomogr 1984;8:91–7.
Montag M, Dören M, Meyer-Galander HM, Montag T, Peters PE. Computertomographischbestimmter Mineralgehalt in der LWS-spongiosa: Normverte für gesunde perimenopausale Frauen und Vergleich dieser Werte mit der mechanischen Wirbelsäulenbelastung. Radiologe 1988;28:161–5.
Compston JE, Evans WD, Crawley EO, Evans C. Bone mineral content in normal UK subjects. Br J Radiol 1988;61:631–6.
Kalender WA, Felsenberg D, Louis O, Lopez P, Klotz E, Osteaux M, Fraga J. Reference values for trabecular and cortical vertebral bone density in single- and dual-energy quantitative computed tomography. Eur J Radiol 1989;9:75–80.
Albertsson MP, Sigurdsson G. Tidni brota í laerleggshalsi, hryggsulu og framhandlegg i Reykjavík 1973–1981. Icelandic Med J 1984;70:253–6.
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Gudmundsdottir, H., Jonsdottir, B., Kristinsson, S. et al. Vertebral bone density in icelandic women using quantitative computed tomography without an external reference phantom. Osteoporosis Int 3, 84–89 (1993). https://doi.org/10.1007/BF01623378
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DOI: https://doi.org/10.1007/BF01623378