Skip to main content

Advertisement

Log in

Single X-ray absorptiometry: Performance characteristics and comparison with single photon absorptiometry

  • Original Article
  • Published:
Osteoporosis International Aims and scope Submit manuscript

Abstract

The aim of the present study was to evaluate a new device for measurement of forearm bone mass using the technique of single X-ray absorptiometry (SXA, DTX-100; Osteometer A/S, Rødovre, Denmark), and to compare the performance with the more traditional single photon absorptiometry (SPA, DT 100; Osteometer A/S, Rødovre, Denmark). The SPA phantom measurements showed a coefficient of variation of 0.43% and 0.42% for bone mineral content (BMC) and bone mineral density (BMD), respectively (39 months including seven source changes). The SXA precision errors were slightly lower with values of 0.30% and 0.30%, respectively. The patient measurements showed SPA coefficients of variation of 0.85% and 0.99% (BMC and BMD) and SXA coefficients of variation of 0.56% and 0.83%, respectively. The correlation between SPA and SXA values performed in 377 individuals yielded r values of 0.99 an 0.98 for BMC and BMD, respectively. The correlations between SXA measurements of the dominant and non-dominant forearm yielded anr-value of 0.95, with a slope of 0.949 (p<0.001) and an intercept of 0.204 (p<0.05). The non-dominant forearm thus had approximately 3% lower BMC than the dominant (the same was true for BMD). Correlations to spine and femur ranged fromr=0.48 tor=0.75. In conclusion, the new single X-ray absorptiometry forearm bone densitometer described in this paper has performance characteristics which allows it to be used both for diagnostic purposes and for the follow-up of treatment.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Mazess RB. On aging bone loss. Clin Orthop 1982;165:239–252.

    Google Scholar 

  2. Haynes WC, Gerhard TN. Biomechanics of bone: applications for assessment of bone strength. In: Peck WA, editor. Bone and mineral research 3. Amsterdam: Elsevier, 1985:259–94.

    Google Scholar 

  3. Riggs BL, Melton LJ. Medical progress: involutional osteoporosis. N Engl J Med 1986;26;314:1676–84.

    Google Scholar 

  4. Gärdsell P, Johnell O, Nilsson BE, Gullberg B. Predicting fragility fractures in women by forearm bone densitometry: a follow-up study. Calcif Tissue Int 1993;52:348–53.

    Google Scholar 

  5. Melton LJ, Atkinson EJ, O'Fallon WM, Wahner HW, Riggs BL. Long-term fracture prediction by bone mineral assessed at different skeletal sites. J Bone Miner Res 1993;8:1227–1232.

    Google Scholar 

  6. A Report from the Scientific Advisory Board of the National Osteoporosis Foundation. Clinical indications for bone mass measurements. J Bone Miner Res 1989;Suppl 2:1–28.

    Google Scholar 

  7. Nilas L, Nørgaard H, Pødenphant J, Gotfredsen A, Christiansen C. Bone composition in the distal forearm. Scand J Clin Lab Invest 1987;47:41–6.

    Google Scholar 

  8. Hassager C, Borg J, Christiansen C. Measurements of the subcutaneous fatin the distal forearm by single photon absorptio-metry. Metabolism 1989;38:159–65.

    Google Scholar 

  9. Hansen MA, Hassager C, Overgaard K, Marslev U, Riis BJ, Christiansen C. Dual-energy x-ray absorptiometry: a precise method of measuring bone mineral density in the lumbar spine. J Nucl Med 1990;31:1156–62.

    Google Scholar 

  10. Svendsen OL, Hassager C, Skødt V, Christiansen C. Accuracy of bone mineral measurement in the spine, hip and forearm: a human cadaver study. Am J Clin Nutr 1993;57:605–8.

    Google Scholar 

  11. Cameron JR, Sorensen J. Measurement of bone mineral in vivo. Science 1963;142:230–2.

    Google Scholar 

  12. Christiansen C, Rødbro P. Long-term reproducibility of bone mineral measurements. Scan J Clin Lab Invest 1977;37:321–3.

    Google Scholar 

  13. Hansen MA, Riis BJ, Overgaard K, Hassager C, Christiansen C. Bone mass measured by photon absorptiometry: comparison of forearm, heel and spine. Scand J Clin Lab INvest 1990;5:517–23.

    Google Scholar 

  14. Kelly TL. Single X-ray absorptiometry of the forearm: precision, correlation and reference data. Calcif Tissue Int 1994;54:212–8.

    Google Scholar 

  15. Faulkner KG, McClung MR, Schmeer MS, Roberts LA, Gaither KW. Densitometry of the radius using single and dual energy absorptiometry. Calcif Tissue Int 1994;54:208–11.

    Google Scholar 

  16. Gotfredsen A, Borg J, Christiansen C, Mazess RB. Total body bone mineral in-vivo by dual photo absorptiometry. I. Measurement procedures. Clin Physiol 1984;4:343–55.

    Google Scholar 

  17. Overgaard K, Hansen MA, Riis BJ, Christiansen C. Discriminatory ability of bone mass measurements (SPA and DEXA) for fractures in elderly postmenopausal women. Calcif Tissue Int 1992;50:30–5.

    Google Scholar 

  18. Nilas L, Pødenphant J, Riis BJ, Gotfredsen A, Christiansen C. Usefulness of regional bone measurements in patients with osteoporotic fractures of the spine and distal forearm. J Nucl Med 1987;28:960–5.

    Google Scholar 

  19. Law M. Wald NJ, Meade TW. Strategies for the prevention of osteoporosis and hip fracture. BMJ 1991;303:453–9.

    Google Scholar 

  20. Black DM, Cummings SR, Genant HK, Nevitt MC, Palermo L, Browner W. Axial and appendicular bone density predict fractures in older women. J Bone Miner Res 1992;7:633–8.

    Google Scholar 

  21. Naeton JD, Wentworth D, for the Multiple Risk Factor Intervention Trial Research Group. Serum cholesterol, blood pressure, cigarette smoking and death from coronary artery disease: overall findings and differences by age for 316 099 white men. Arch Intern Med 1992;152:56–64.

    Google Scholar 

  22. Khaw KT. predictors of stroke-associated mortality in the elderly. Stroke 1984;152:56–64.

    Google Scholar 

  23. Hassager C et al. The impact of measurement errors on the diagnostic value of bone mass measurements: thoretical considerations. Osteoporosis Int 1991;1:1250–6.

    Google Scholar 

  24. Marslew U et al. Desogestrel in hormone replacement therapy: long-term effects on bone, calcium and lipid metabolism, climacteric symptoms, and bleeding. Eur J Clin Inv 1991;21:601–7.

    Google Scholar 

  25. Overgaard K, Riis BJ, Christiansen C, Pødenphant J, Johansen JS. Nasal calcitonin for treatment of established osteoporosis. Clin Endocrinol 1989;30:435–42.

    Google Scholar 

  26. Johansen JS, Hassager C, Pødenphant J, Riis BJ, Hartwell D, Thomsen K, Christiansen C. Treatment of postmenopausal osteoporosis: is the anabolic steroid nandrolone dacanoate a candidate? Bone Miner 1989;6:77–86.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Borg, J., Møllgaard, A. & Riis, B.J. Single X-ray absorptiometry: Performance characteristics and comparison with single photon absorptiometry. Osteoporosis Int 5, 377–381 (1995). https://doi.org/10.1007/BF01622260

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01622260

Keywords

Navigation