Summary
Three osteosarcomas (OS) with features resembling malignant fibrous histiocytoma (MFH) were selected and investigated to identify any clinico-pathological similarities. In all cases there was no significant difference from conventional OS on the radiography and laboratory data. The appearance of MFH-like features within the whole tumour tissue varied from 7% to 55%. It was composed of spindle-shaped cells arranged in short irregular fascicles and a storiform pattern admixed with osteoclast-like giant cells, but devoid of neoplastic osteoid. Such spindle-shaped cells had a poorly developed rough endoplasmic reticulum and expressed a strong alkaline phosphatase activity as well as vimentin. A series of allografts to athymic mice using the MFH-like tissues also showed histologically a proliferation of plump spindle-shaped cells with a storiform pattern lacking osteoclast-like giant cells, and intensely positive for alkaline phosphatase. These findings indicate that the MFH-like features are identified as modulated OS. The constituting cells are most likely to be poorly developed with possible phenotypic alteration in the maturation stage of osteoblastic cell lineage, but different from conventional MFH of bone as regards their distinct histochemical pattern.
Similar content being viewed by others
References
Aki T (1989) Purification and characterization of antisera to aminopeptidase M and dipeptidyl peptidase IV, and their application to fibroblasts and fibroblastic tumors (in Japanese). Yonago Igaku Zasshi 40:10–21
Ballance WA, Mendelsohn G, Carter JR, et al (1988) Osteogenic sarcoma: malignant fibrous histiocytoma subtype. Cancer 62:763–771
Bengt AM, Lagerlof BMA, Kaplan HS (1967) Specificity of the relationship between thymic alkaline phosphatase activity and lymphoma development in strain C57BL mice. J Natl Cancer Inst 38:437–458
Breiweiss IJ, Kaneko M (1988) Chondrosarcoma of the larynx with additional malignant mesenchymal component. Am J Surg Pathol 12:314–320
Brooks JJ (1986) The significance of double phenotypic patterns and markers in human sarcoma: a new model of mesenchymal differentation. Am J Pathol 125:113–123
Dahlin DC, Unni KK (1977) Osteosarcoma of bone and its important recognizable varieties. Am J Surg Pathol 1:61–72
Hashimoto H, Daimaru Y, Tsuneyoshi M, et al (1986) Leiomyosarcoma of the external soft tissues. A clinicopathologic, immunohistochemical and electron microscopic study. Cancer 57:2077–2088
Hayashi M, Nakajima Y, Fishman W (1964) The cytologic demonstration ofβ-glucuronidase employing naphtol AS-BI glucuronide and hexazonium pararosalinin. A preliminary report. J Histochem Cytochem 12:239–247
Huvos AG (1986) Osteogenic sarcoma of bones and soft tissues in older persons. Cancer 57:1442–1449
Huvos AG, Heilweil M, Bretsky SS (1985) The pathology of malignant fibrous histiocyloma of bone. A study of 30 patients. Am J Surg Pathol 9:853–871
Jaworski R (1984) Dedifferentiated chondrosarcoma: an ultrastructural study. Cancer 53:2674–2678
Jeffree GM, Price CH (1965) Bone tumours and their enzymes. J Bone Joint Surg [Br] 47:120–136
Kim YJ, Yu SE, Lee KW, et al (1989) Dedifferentiated liposarcoma of the liver. Cancer 60:2785–2790
Kosmell H, Langbine L, Katenkamp D (1990) Experimental rhabdomyosarcoma with regions like malignant fibrous histiocytoma (MFH): a true double phenotypic pattern? J Pathol 160:135–140
Eeder LD (1964) Über die selektive formentzytochemische Darstellung von neutrophilen myeloischen Zellen und Gewebsmastzellen im Paraffinschnitt. Klin Wochenschr 42:55
Minamizaki T, Yoshida H, Yumoto T (1990) Alkaline phosphatase-positive and negative tumors: immunohistochemical and ultrastructural studies of fibroblast-like tumor cells. Pathol Res Pract 186:633–641
Mirra JM (1980) Bone tumors: diagnosis and treatment. Lippincott, Philadelphia, pp 287–288
Müller-Hermelink HK (1974) Characterization of the B-cell and T-cell regions of human lymphatic tissue through enzyme histochemical demonstration of ATPase and 5′-nucleotidase activities. Virchows Archiv B Cell Pathol 16:371–378
Roholl PJM, Rutgers DH, Rademakcrs EHPM, et al (1988) Characterization of human soft tissue sarcoma in nude mice; evidence for histogenetic properties of malignant fibrous histiocytomas. Am J Pathol 131:559–568
Unni KK (1988) Bone tumors: contemporary tissues in surgical pathology. Churchill Eivingstone, Edinburgh, pp 107–133
Wick MR, Siegal GP, Mills SE, et al (1987) Dedifferentiated chondrosarcoma of bone. An immunohistochemical and lectinhistochemical study. Virchows Arch [A] 411:23–32
Yoshida H, Akeho M, Orito T, et al (1982) Enzyme histochemical study on bone tumors. Acta Med Okayama 36:469–482
Yumoto T, Naniwa S, Yoshida H, et al (1988) Establishment and characterization of a murine Gardner's osteosarcoma cell line (GOS/T): purification of bone-specific alkaline phosphatase (AEPase) and use of anti-ALPase as a diagnostic aid. Exp Pathol 35:177–187
Yunis EJ, Barnes L (1986) The histologic diversity of osteosarcoma. In: Sommers SC, Rosen PP, Fechner RE (eds) Pathology annual, part. Appleton-Century-Crofts Norwalk, pp 121–141
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Yoshida, H., Yumoto, T. & Minamizaki, T. Osteosarcoma with features mimicking malignant fibrous histiocytoma. Vichows Archiv A Pathol Anat 421, 229–238 (1992). https://doi.org/10.1007/BF01611180
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01611180