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Activation of natural killer (NK) cells in vivo with H-2 and non-H-2 alloantigens

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Abstract

Intraperitoneal inoculation of allogeneic lymphoid cells rapidly activates cytotoxic cells in the peritoneum which are nonadherent and express the NK-1, asialo-GM1, and Thy-1 antigens. Allogeneic spleen cells were very efficient at activating these natural killer (NK) cells, while allogeneic thymocytes were much less effective. Heat-killed allogeneic cells or sonicates also could augment NK activity. — Incompatibility atH-2K, H-2I-A, orH- 2D readily evoked NK cell activity, whileH-2S- andH-2I-E/C-associated disparities did not. Non-H- 2 differences also stimulated NK activity and augmentation was particularly evident inMls-disparate combinations. Thus, the same alloantigens which efficiently activate T cells also activate NK cells.

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  1. Department of Genetics, Regional Primate Research Center, University of Washington SK-50, 98195, Seattle, Washington

    Edward A. Clark & Richard D. Holly

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  1. Edward A. Clark
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Clark, E.A., Holly, R.D. Activation of natural killer (NK) cells in vivo with H-2 and non-H-2 alloantigens. Immunogenetics 12, 221–235 (1981). https://doi.org/10.1007/BF01561666

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  • DOI: https://doi.org/10.1007/BF01561666

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