Summary
Sulfasalazine, a drug used in the treatment of inflammatory bowel disease, has been associated with male infertility, an effect attributed to sulfapyridine rather than to 5-aminosalicylic acid (5-ASA), the presumed therapeutically active component of sulfasalazine. Recently, the sperm penetration assay (SPA) has been found to be an accurate method of quantitating male fertilization potential. We report the case of a man with ulcerative colitis in whom infertility and a markedly abnormal SPA were demonstrated while he was taking sulfasalazine. Shortly after discontinuing sulfasalazine and initiating treatment with 5-ASA enemas, his SPA became normal and his wife became pregnant. The SPA is a useful screening test for sulfasalazine-induced male infertility. On the other hand, 5-ASA enemas do not appear to be associated with an abnormal SPA.
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Svartz N: Salazopyrine, a new sulfanilimide preparation. Acta Med Scand 110:577–598, 1942
Svartz N: The treatment of 124 cases of ulcerative colitis with salazopyrine and attempts of densensibilization in cases of hypersensitiveness to sulfa. Acta Med Scand 206:465–472, 1948
Toth A: Reversible toxic effect of salicylazosulfapyridine on semen quality. Fertil Steril 1:538–540, 1979
Levi AJ, Fisher AM: Male infertility due to sulphasalazine. Lancet 2:276–278, 1979
Toth A: Male infertility due to sulphasalazine. Lancet 2:904, 1979
Traub AI, Thompson W, Carville J: Male infertility due to sulphasalazine. Lancet 2:639–640, 1979
Grieve J: Male infertility due to sulphasalazine. Lancet 2:464, 1979
Collen MJ: Azulfidine-induced oligospermia. Am J Gastroenterol 74:441–442, 1980
Toovey S, Hudson E, Hendry WF, Levi AJ: Sulphasalazine and male infertility: Reversibility and possible mechanism. Gut 22:445–451, 1981
Birnie GG, McLeod TIF, Watkinson G: Incidence of sulphasalazine-induced male infertility. Gut 22:452–455, 1981
Hudson E, Dore C, Sowter C, Toovey S, Levi AH: Sperm size in patients with inflammatory bowel disease on sulfasalazine therapy. Fertil Steril 38:77–84, 1982
Taffet SL, Das KM: Sulfasalazine-adverse effects and densensitization. Dig Dis Sci 28:833–842, 1983
O'Morain C, Smethurst P, Dore CJ, Levi AJ: Reversible male infertility due to sulphasalazine: Studies in man and rat. Gut 25:1078–1084, 1984
Cann PA, Holdsworth CD: Reversal of male infertility on changing treatment from sulphasalazine to 5-aminosalicylic acid. Lancet 1:1119, 1984
Shaffer JL, Kershaw, Berrisford MH: Sulphasalazine-induced infertility reversed on transfer to 5-aminosalicylic acid. Lancet 1:1240, 1984
Yanagimachi R, Yanagimachi H, Rogers BJ: The use of zona-free animal ova as a test system for the assessment of the fertilizing capacity of human spermatazoa. Biol Reprod 15:471–476, 1976
Karp LE, Williamson RA, Moore DE, Shy KK, Plymate SR, Smith WD: Sperm penetration assay: Useful test in evaluation of male fertility. Obstet Gynecol 57:620–623, 1981
Margalioth EJ, Navot D, Beyth Y: Diagnosis of drug-related male infertility by zona-free hamster egg sperm penetration assay. Lancet 1:275, 1985
Guarino J, Berk T, Friedman LS: 5-Aminosalicylic acid (5-ASA) enemas in distal ulcerative colitis (UC): Maintenance of remission. Gastroenterology 90:1441, 1986 (abstract)
Hall JL: Relationship between semen quality and human sperm penetration of zona-free hamster ova. Fertil Steril 35:457–463, 1981
Martin RH, Taylor PJ: Reliability and accuracy of the zona-free hamster ova assay in the assessment of male infertility. Br J Obstet Gynecol 89:951–956, 1982
Rogers BJ, Mygatt GG, Soderdahl DW, Hale RW: Monitoring of suspected infertile men with varicocele by the sperm penetration assay. Fertil Steril 44:800–805, 1985
Rogers BJ: The sperm penetration assay: its usefulness reevaluated. Fertil Steril 43:821–840, 1985
Evans JA: Sperm penetration assay. Fertil Steril 45:141, 1986 (letter)
Rogers BJ. Sperm penetration assay. Fertil Steril 45:141–142, 1986 (reply)
Bondesen S, Haagen Nielsen O, Jacobsen O, Rasmussen SN, Hansen SH, Halkov S, Binder V, Hvidberg EF: 5-Aminosalicylic acid enemas in patients with active ulcerative colitis. Influence of acidity on the kinetic pattern. Scand J Gastroenterol 19:677–682, 1984
Friedman LS, Richter JM, Kirkham SE, DeMonaco HJ, May RJ: 5-Aminosalicylic acid enemas in refractory distal ulcerative colitis: A randomized, controlled trial. Am J Gastroenterol 81:412–418, 1986
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Chatzinoff, M., Guarino, J.M., Corson, S.L. et al. Sulfasalazine-induced abnormal sperm penetration assay reversed on changing to 5-aminosalicylic acid enemas. Digest Dis Sci 33, 108–110 (1988). https://doi.org/10.1007/BF01536639
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DOI: https://doi.org/10.1007/BF01536639