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Role of eosinophilic granulocytes in women with infertility and pelvic adhesions

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Abstract

Increased numbers of eosinophilic granulocytes and eosinophil degranulation have been observed in various inflammatory conditions. Biopsies from the fallopian tubes of 28 patients were examined for the content of eosinophilic granulocytes. Peritoneal fluids (PF) from 89 patients were analyzed for the concentrations of eosinophilic granulocytes and the granule protein eosinophil cationic protein (ECP). The ECP levels in the PF were substantially elevated during genital inflammation (P < 0.001). Furthermore, one week after laparotomy for adhesiolysis there were both increased PF-ECP levels (P < 0.01) and raised concentrations of eosinophilic granulocytes (P < 0.001) when compared to the reference group. Staining of the biopsies with monoclonal antibodies revealed an increased total number as well as a number of activated eosinophilic granulocytes in specimens from adhesions and sactosalpinx compared to specimens from normal fimbriae. The findings indicate that eosinophilic granulocytes may have a possible role in the fibrotic process of pelvic adhesion disease.

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Author notes

  1. Greta Edelstam

    Present address: Obstetrics and Gynecology, Nacka Hospital, S-131 83, Nacka, Sweden

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Uppsala University, Uppsala, Sweden

    Greta Edelstam

  2. Department of Neurobiology, University of Arhus, Arhus, Denmark

    Kjeld Fredens

  3. Department of Clinical Chemistry, Uppsala University, Uppsala, Sweden

    Per Venge

Authors
  1. Greta Edelstam
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  2. Kjeld Fredens
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  3. Per Venge
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Edelstam, G., Fredens, K. & Venge, P. Role of eosinophilic granulocytes in women with infertility and pelvic adhesions. Inflammation 18, 361–371 (1994). https://doi.org/10.1007/BF01534434

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