Skip to main content
SpringerLink
Log in

Regulation of cartilage growth by growth hormone and insulin-like growth factor I

  • Growth Review Article
  • Published:
Pediatric Nephrology Aims and scope Submit manuscript

Abstract

A number of studies have shown that growth hormone (GH) and insulin-like growth factor-I (IGF-I) have important regulatory roles for skeletal growth. However, it has been a matter of controversy whether GH acts directly on cells in the growth plate or if the growth-promoting effects of GH are mediated by liver-derived (endocrine-acting) IGF-I. With the recognition that GH regulates the production of IGF-I in multiple extra-hepatic tissues, autocrine and paracrine functions of IGF-I have been suggested as important components of GH action. This review focuses on recent developments in our understanding of the cellular mechanisms by which GH promotes longitudinal bone growth and the inter-relationship between GH and IGF-I in the growth plate.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Salmon WD Jr, Daughaday WH (1957) A hormonally controlled serum factor which stimulates sulfate incorporation in vitro. J Lab Clin Med 49: 825–836

    PubMed  Google Scholar 

  2. Nilsson A, Isgaard J, Lindahl A, Peterson L, Isaksson OGP (1987) Effects of unilateral arterial infusion of GH and IGF-I on tibial longitudinal bone growth in hypophysectomized rats. Calcif Tissue Int 40: 91–96

    PubMed  Google Scholar 

  3. Schlechter NL, Russell SM, Spencer EM, Nicoll CS (1986) Evidence suggesting that the direct growth promoting effect of growth hormone on cartilage in vivo is mediated by local production of somatomedin. Proc Natl Acad Sci USA 83: 7932–7934

    PubMed  Google Scholar 

  4. Barnard R, Haynes KM, Werther GA, Waters MJ (1988) The ontogeny of growth hormone receptors in the rabbit tibia. Endocrinology 122: 2562–2569

    PubMed  Google Scholar 

  5. Edén S, Isaksson OGP, Madsen K, Friberg U (1983) Specific binding of growth hormone to isolated chondrocytes from rabbit ear and epiphyseal plate. Endocrinology 112: 1127–1129

    PubMed  Google Scholar 

  6. Nilsson A, Lindahl A, Edén S, Isaksson OGP (1989) Demonstration of growth hormone receptors in cultured rat epiphyseal chondrocytes by specific binding of growth hormone and immunohistochemistry. J Endocrinol 122: 69–77

    PubMed  Google Scholar 

  7. Nilsson A, Carlsson B, Mathews L, Isaksson OGP (1990) Growth hormone regulation of the growth hormone receptor mRNA in cultured rat epiphyseal chondrocytes. Mol Cell Endocrinol 70: 237–246

    PubMed  Google Scholar 

  8. D'Ercole AJ, Stiles AD, Underwood LE (1984) Tissue concentrations of somatomedin-C: further evidence for multiple sites of synthesis and paracrine or autocrine mechanisms of action. Proc Natl Acad Sci USA 81: 935–939

    PubMed  Google Scholar 

  9. Nilsson A, Isgaard J, Lindahl A, Dahlström A, Skottner A, Isaksson OGP (1986) Regulation by growth hormone of number of chondrocytes containing IGF-I in rat growth plate. Science 233: 571–574

    PubMed  Google Scholar 

  10. Isgaard J, Möller C, Isaksson OGP, Nilsson A, Mathews LS, Norstedt G (1988) Regulation of insulin-like growth factor messenger ribonucleic acid in rat growth plate by growth hormone. Endocrinology 122: 1515–1520

    PubMed  Google Scholar 

  11. Nilsson A, Carlsson B, Isgaard J, Isaksson OGP, Rymo L (1990) Regulation by GH of insulin-like growth-factor-I mRNA expression in rat epiphyseal growth plate as studied with in situ hybridization. J Endocrinol 125: 67–74

    PubMed  Google Scholar 

  12. Isgaard J, Carlsson L, Isaksson OGP, Jansson J-O (1988) Pulsatile intravenous growth hormone infusion to hypophysectomized rats increases insulin-like growth factor I messenger ribonucleic acid in skeletal tissues more effectively than continuous GH infusion. Endocrinology 123: 2605–2610

    PubMed  Google Scholar 

  13. Maor G, Hochberg Z, von der Mark K, Heinegard D, Silbermann M (1989) Human growth hormone enhances chondrogenesis and osteogenesis in a tissue culture system of chondroprogenitor cells. Endocrinology 125: 1239–1245

    PubMed  Google Scholar 

  14. Lindahl A, Isgaard J, Nilsson A, Isaksson OGP (1986) Growth hormone potentiates colony formation of epiphyseal chondrocytes in suspension culture. Endocrinology 118: 1843–1848

    PubMed  Google Scholar 

  15. Lindahl A, Nilsson A, Isaksson OGP (1987) Effects of growth hormone and insulin-like growth factor-I on colony formation of rabbit epiphyseal chondrocytes at different stages of maturation. J Endocrinology 115: 263–271

    Google Scholar 

  16. Green H, Morikawa M, Nixon T (1985) A dual effector theory of growth hormone action. Differentiation 29: 195–198

    PubMed  Google Scholar 

  17. Isaksson OGP, Lindahl A, Nilsson A, Isgaard J (1987) Mechanism for the stimulatory effect of growth hormone on longitudinal bone growth. Endocr Rev 8: 426–438

    PubMed  Google Scholar 

  18. Ohlsson C, Nilsson A, Isaksson O, Lindahl A (1991) Effects of growth hormone (GH) and insulin-like growth factor I (IGF-I) on DNA synthesis and matrix production in rat epiphyseal chondrocytes cultured at different cell densities, 2nd Int. IGF-I Symposium, San Fransisco, p 191 (Abstract)

Download references

Author information

Authors and Affiliations

  1. Department of Physiology, University of Gothenburg, S-40033, Gothenburg, Sweden

    Olle G. P. Isaksson, Claes Ohlsson, Anders Nilsson, Jörgen Isgaard & Anders Lindahl

Authors
  1. Olle G. P. Isaksson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Claes Ohlsson
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Anders Nilsson
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jörgen Isgaard
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Anders Lindahl
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Isaksson, O.G.P., Ohlsson, C., Nilsson, A. et al. Regulation of cartilage growth by growth hormone and insulin-like growth factor I. Pediatr Nephrol 5, 451–453 (1991). https://doi.org/10.1007/BF01453680

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01453680

Key words

Search

Navigation