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Ursodeoxycholic acid in the treatment of cholesterol cholelithiasis part II

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References

  1. Adler RD, Bennion LJ, Duane WC, Grundy SM: Effects of low dose chenodeoxycholic acid feeding on biliary lipid metabolism. Gastroenterology 68:326–334, 1975

    PubMed  Google Scholar 

  2. Aldini R, Mazzella G, Rossi RM, Cappelleri G, Roda E, Barbara L: Serum UDCA tolerance test in liver disease. Sixteenth meeting of the European Association for the Study of the Liver, Lisbon, Sept 3–5, 1981, No. 98 (abstract)

  3. Alessandrini A, Ripoli F, Boscaini M, Arcangeli A, Gentilini P, Blasi A, Mangiameli A, Fontana G, Costa L, Mazzacca G, D'Arienzo A, Okolicsanyi L, Lirussi F: A multicentre clinical trial on ursodeoxycholic acid: effect of different dosages upon cholesterol gallstone dissolution. Ital J Gastroenterol 12:185–188, 1980

    Google Scholar 

  4. Allan RN, Thistle JL, Hofmann AF: Lithocholate metabolism during chenotherapy for gallstone dissolution. 2. Absorption and sulfation. Gut 17:413–419, 1976

    PubMed  Google Scholar 

  5. Allan RN, Thistle JS, Hofmann AF, Carter JA, Yu PYS: Lithocholate metabolism during chenotherapy for gallstone dissolution. 1. Serum levels of sulphated and unsulphated lithocholates. Gut 17:405–412, 1976

    PubMed  Google Scholar 

  6. Angelin B, Ahlberg J, Björkhem, Einarsson K, Ewerth S: Serum levels of individual bile acids in portal venous and systemic circulation during treatment with chenodeoxycholic acid and cholic acid.In Biological Effects of Bile Acids, G Paumgartner, A Stiehl, W Gerok (eds). Lancaster, England, MTP Press, 1979, pp 107–108

    Google Scholar 

  7. Aries V, Hill MJ: Degradation of steroids by intestinal bacteria. II. Enzymes catalysing the oxidoreduction of the 3α, 7α-, and 12α-hydroxyl groups in cholic acid, and the dehydroxylation of the 7-hydroxyl group. Biochim Biophys Acta 202:535–543, 1970

    PubMed  Google Scholar 

  8. Attili AF, Angelico M, Cantafora A, DeBiase A, Capocaccia P, Gualdi GF, Capocaccia L: Effect of low doses of ursodeoxycholic acid on biliary lipid composition in nonobese gallstone patients. Ital J Gastroenterol 10:119–120, 1978

    Google Scholar 

  9. Attili AF, Angelico M, Capocaccia P, Gualdo G, Cantafora A, DeBiase A, Capocaccia L, Giunchi G: Effect of ursodeoxycholic acid on biliary lipid composition. A double blind study. Ital J Gastroenterol 12:177–180, 1980

    Google Scholar 

  10. Attili AF, DeBiase A, Pieche U, Cantafora A, Angelico M, Pueti C, Capocaccia L: Glyco/tauro ursodeoxycholate ratio during treatment with large doses of ursodeoxycholic acid. Effect of taurine dietary supplementation. VI International Bile Acid Meeting, “Bile Acids and Lipids.” Freiburg, W. Germany, Oct 1980, p 195 (abstract)

  11. Autrup H, Aage H, Barrett L: Effect of bile acids on cultured human colon. 1980 Workshop “Bile Acids and Large Bowel Carcinogenesis”. M.D. Anderson Hospital and Tumor Institute, p 43

  12. Baba S, Suminoe K, Venoyama R, Hasegawa S, Takeda F, Kameno Y: Studies on ursodeoxycholic acid tolerance test in hepatobiliary diseases with special reference to dynamic changes of individual serum bile acids. J Clin Chem Clin Biochem 19:605, 1981 (abstract)

    Google Scholar 

  13. Barnes S, Waldrop R, Spenney JG: Diminished enzymatic bile salt sulfation in rhesus monkeys. Gastroenterology 80 (part 2):1326, 1981 (abstract)

    Google Scholar 

  14. Bateson MC: Bile acid therapy and radiolucent gallstones. VI International Bile Acid Meeting, Freiburg, W. Germany, Oct 9–11, 1980, p 182 (abstract)

  15. Bateson MC, Bouchier IAD: Therapy with chenodeoxycholic acid (CDCA) and ursodeoxycholic acid (UDCA) in hyperlipidaemia. VII International Symposium on Drugs Affecting Lipid Metabolism, Milan, Italy, May 1980 (abstract)

  16. Bateson MC, Hill A, Bouchier IAD: Analysis of response to ursodeoxycholic acid for gallstone dissolution. Digestion 20:358–364, 1980

    PubMed  Google Scholar 

  17. Bateson MC, Hopwood D, Bouchier IAD: Effect of gallstone dissolution therapy on human liver structure. Am J Dig Dis 22:293–299, 1977

    PubMed  Google Scholar 

  18. Bateson MC, Maudgal DP, Trash DB, Northfield TC, Bouchier IAD: Gallstone Calcification caused by ursodeoxycholic acid. Gut 22:A-432, 1981 (abstract)

    Google Scholar 

  19. Bateson MC, Ross PE, Murison J, Bouchier IAD: Effect of prolonged chenodeoxycholic acid feeding on bile in patients with and without gallstones. Gut 18:A-419, 1977 (abstract)

    Google Scholar 

  20. Bateson MC, Ross PE, Murison J, Bouchier IAD: Effect of prolonged feeding with chenodeoxycholic acid on bile in patients with and without gallstones. Gut 18:599–605, 1977

    PubMed  Google Scholar 

  21. Bateson M, Ross PE, Murison J, Saunders JHB, Bouchier IAD: Ursodeoxycholic acid therapy and biliary lipids—a dose-response study. Gut 21:305–310, 1980

    PubMed  Google Scholar 

  22. Bateson MC, Trash DB, Bouchier IAD: Can a six-month cholecystogram predict eventual response to gallstone dissolution therapy? Gut 21:A-443, 1980 (abstract)

    Google Scholar 

  23. Batta AK, Salen G, Shefer S: The effect of feeding tauroursodeoxycholic acid on biliary bile acid composition. Gastroenterology 80(part 2):1106, 1981 (abstract)

    Google Scholar 

  24. Bazzoli F, Fromm H, Roda A, Sarva RP, Roda E: Bile acid metabolism in relation to hepatotoxicity after treatment with chenodeoxycholic (CDC) and ursodeoxycholic (UDC) acids in the rhesus monkey. VI International Bile Acid Meeting, “Bile Acids and Lipids.” Freiburg, W. Germany, Oct 1980, p 197 (abstract)

  25. Bazzoli F, Geminiani S, Roda A, Mazzella G, Sama C, Aldini R, Morselli AN, Festi D, Roda E, Barbara L: Ursodeoxycholic acid in the dissolution of cholesterol gallstones: a blind-controlled trial. Ital J Gastroenterol, Suppl 11:115, 1979 (abstract). Preliminary reportin Workshop in Ursodeoxycholic Acid, RH Dowling, AF Hofmann, L Barbara (eds). Lancaster, England, MTP Press, 1978, pp 66–70

    Google Scholar 

  26. Bazzoli F, Sarva RP, Fromm H, Ceryak S: Comparative formation of lithocholic acid (LC) from ursodeoxycholic (UDC) and chenodeoxycholic (CDC) acids in the human colon. American Association for the Study of Liver Diseases, Chicago, Nov 1980, p 5 (abstract)

  27. Bazzoli F, Sarva RP, Fromm H, Ceryak S, Sembrat RF: Lithocholic acid (LC) is formed from chenodeoxycholic (CDC) and ursodeoxycholic (UDC) acids at a similar rate. Gastroenterology 80(part 2):1107, 1981 (abstract)

    Google Scholar 

  28. Bell GD, Dowling RH, Whitney B, Sutor DJ: The value of radiology in predicting gallstone type when selecting patients for medical treatment. Gut 16:359–364, 1975

    PubMed  Google Scholar 

  29. Bell GD, Whitney B, Dowling RH: Gallstone dissolution in man using chenodeoxycholic acid. Lancet 2:1213–1216, 1972

    PubMed  Google Scholar 

  30. van Berge Henegouwen GP, Brandt KH, Eyssen H, Parmentier G: Sulphated and unsulphated bile acids in serum, bile, and urine of patients with cholestasis. Gut 17:861–869, 1976

    PubMed  Google Scholar 

  31. van Berge Henegouwen GP, Hofmann AF: Pharmacology of chenodeoxycholic acid. II. Absorption and metabolism. Gastroenterology 73:300–309, 1977

    PubMed  Google Scholar 

  32. von Bergmann K, Gutsfeld M, Schulze-Hagen K, von Unruh G: Effects of ursodeoxycholic acid on biliary lipid secretion in patients with radiolucent gallstones.In Biological Effects of Bile Acids, G Paumgartner, A Stiehl, W Gerok (eds). Lancaster, England, MTP Press, 1979, pp 61–66

    Google Scholar 

  33. von Bergmann K, Leiss O: Effects of bile acid feeding on lipoprotein metabolism and on biliary lipid secretion in patients with radiolucent gallstones. VI International Bile Acid Meeting, “Bile Acids and Lipids.” Freiburg, W. Germany, Oct 1980, p 60 (abstract)

  34. von Bergmann K, Strottköter H, Leiss O: Decreased cholesterol absorption during ursodeoxycholic acid administration. Hepatology 1:670, 1981 (abstract)

    Google Scholar 

  35. Bergstrom S, Lindstedt S, Samuelsson B: Bile acids and steroids. 82: On the mechanism of deoxycholic acid formation in the rabbit. J Biol Chem 243:2022–2025, 1959

    Google Scholar 

  36. Borgstrom B, Lundh G, Hofmann AF: The site of absorption of conjugated bile salts in man. Gastroenterology 45:229–238, 1963

    PubMed  Google Scholar 

  37. Bouma ME, Levy VG, Infante R: Liver ultrastructure in gallstone patients before and after chenotherapy. Gastroenterol Clin Biol 4:569–576, 1980

    PubMed  Google Scholar 

  38. Caciagli F, Bonvicini F, Ciccarelli R, Corazza GR, D'Angelo C, Gasbarrini G: Effetto degli acidi biliari sulla mucosa del colon. Interferenze farmacologiche sui livelli intracellulari di cGMP della mucosa colica umani di pazienti trattati con acidi biliari. Correlazione cliniche con le modificazione dell'alvo. 5th International Symposium on Bile Acids, Cortina d'Ampezzo, Italy, March 1979, p 31 (abstract)

  39. Camilleri M, Murphy R, Chadwick VS: Dose-related effects of chenodeoxycholic acid in the rabbit colon. Dig Dis Sci 25:433–438, 1980

    PubMed  Google Scholar 

  40. Camilleri M, Murphy R, Chadwick VS: Inhibition of chenodeoxycholic acid induced secretion in the rabbit colon. Eur J Clin Invest 11(part II):34, 1981 (abstract)

    Google Scholar 

  41. Campa PP: Chenodeoxycholic acid vs ursodeoxycholic acid in biliary tract dynamics in cholecystectomized patients. Ital J Gastroenterol 12:348–349, 1980

    Google Scholar 

  42. Canepa A, Volpi C, Ciravegna G, Dodero M, Celle G: Clinical experiences concerning gallstones dissolution with ursodeoxycholic acid. Acta Gastroenterol Belg 43:502–507, 1980

    PubMed  Google Scholar 

  43. Carey JB Jr, Wilson ID, Zaki FG, Hanson RF: Metabolism of bile acids with special reference to liver injury. Medicine 45:461–470, 1966

    PubMed  Google Scholar 

  44. Carey MC, Igimi H: Physical-chemical basis for dissimilar intraluminal solubilities and intestinal absorption efficiencies of chenodeoxycholic acid and ursodeoxycholic acid.In Bile Acids and Lipids, G Paumgartner, A Stiehl, W Gerok (eds). Lancaster, England, MTP Press, 1981, pp 123–132

    Google Scholar 

  45. Carey MC, Ko G: The importance of total lipid concentration in determining cholesterol solubility in bile and the development of critical tables for calculating “percent cholesterol saturation” with a correction factor for ursodeoxycholate-ric bile.In Biological Effects of Bile Acids, G Paumgartner, A Stiehl, W Gerok (eds). Lancaster, England, MTP Press, 1979, pp 299–308

    Google Scholar 

  46. Carey MC, Montet J-C, Phillips MC, Armstrong MJ, Mazer N: Thermodynamic and molecular basis for dissimilar cholesterol solubilizing capacities by micellar solutions of bile salts; cases of sodium chenodeoxycholate and sodium ursodeoxycholate and their glycine and taurine conjugates. Biochemistry 20:3637–3648, 1981

    PubMed  Google Scholar 

  47. Carey MC, Salvioli G: Differential detergent effects of taurochenodeoxycholate (TCDC) and taurourosodeoxycholate (TUDC) on lecithin and cholesterol secretion from model membranes: Description of a novelin vitro perfusion system. Fourth International GSTAAD Symposium, Switzerland, Sept 8–10, 1981, p 6 (abstract)

  48. Carey MC, Small DM: The physical chemistry of cholesterol solubility in bile. Relationship to gallstone formation and dissolution in man. J Clin Invest 61:998–1026, 1978

    PubMed  Google Scholar 

  49. Carey MC, Wu SJ, Watkins JB: Solution properties of sulfated monohydroxy bile salts. Relative insolubility of the disodium salt of glycolithocholate sulfate. Biochim Biophys Acta 575:16–26, 1979

    PubMed  Google Scholar 

  50. Carulli N, Ponz de Leon M, Podda M, Zuin M, Strata A, Digrisolo A, Frigerio G: Chenodeoxycholic acid and ursodeoxycholic acid effects in endogenous hypertriglyceridemias. A controlled double-blind trial (in press)

  51. Carulli N, Ponz de Leon M, Zironi F, Pinetti A, Smerieri A, Iori R, Moria P: Hepatic cholesterol and bile acid metabolism in subjects with gallstones: Comparative effects of short-term feeding of chenodeoxycholic and ursodeoxycholic acid. J Lipid Res 21:35–43, 1980

    PubMed  Google Scholar 

  52. Casanova S, Roda E, Geminiani S, Zappi A, Rossi R: Effect of CDCA treatment on intestinal structure and function. 5th International Symposium on Bile Acids, Cortina d'Ampezzo Italy, March 1979, p 33 (abstract)

  53. Caspary WF, Meyne K: Comparative effects of urso- and chenodeoxycholic acid on colonic and small intestinal function in rats.In Biological Effects of Bile Acids, G Paumgartner, A Stiehl, W Gerok (eds). Lancaster, England, MTP Press, 1979, pp 233–240

    Google Scholar 

  54. Celle G, Cavanna M, Bocchini R, Robbiano L, Dodero M, Volpi C, Dellepiane F, Cuneo-Crovari P, Scarvaglieri-Giuliano R, Sigari-Canu G: Chenodeoxycholic acid (CDCA) versus ursodeoxycholic acid (UDCA): a comparison of their effects in pregnant rats. Arch Int Pharmacodyn 246:149–158, 1980

    PubMed  Google Scholar 

  55. Chadwick VS, Gaginella TS, Carlson GL, Debongnie J-C, Phillips SF, Hofmann AF: Effect of molecular structure on bile acid-induced alterations in absorptive function, permeability, and morphology in the perfused rabbit colon. J Lab Clin Med 94:611–674, 1979

    Google Scholar 

  56. Chiarantini E, Arcangeli A, Romagnoli P, Buzzelli G, Salvadori G, Gentilini P: Functional and ultrastructural changes in the liver during CDCA treatment. Ital J Gastroenterol 12:224–227, 1980

    Google Scholar 

  57. Chirone E, Zaccherotti L, Fanteria E, Quaranta S, Camarri E: Confronto fra acido chenico ed ursodesossicolico nel trattamento della litiasi colesterolica e della dislipidemia tipo IV. 5th International Symposium on Bile Acids, Cortina d'Ampezzo, Italy, March 1979, p 35 (abstract)

  58. Ciravegna G, Volpi C, Canepa A, Michetti P, Dodero M, Celle G: UDCA e litiasi colesterolica: osservazioni cliniche. 5th International Symposium on Bile Acids, Cortina d'Ampezzo, Italy, March 1979, p 36 (abstract)

  59. Connor WE, Witiak DT, Stone DB, Armstrong ML: Cholesterol balance and fecal neutral steroid and bile acid excretion in normal men fed dietary fats of different fatty acid composition. J Clin Invest 48:1363–1375, 1969

    PubMed  Google Scholar 

  60. Corrigan OI, Su CC, Higuchi WI, Hofmann AF: Mesophase formation during cholesterol dissolution in ursodeoxycholate-lecithin solutions: new mechanism for gallstone dissolution in humans. J Pharm Sci 69:869–871, 1980

    PubMed  Google Scholar 

  61. Cousar CD, Gadacz TR: Comparison of antacids on the binding of bile salts. Gastroenterology 80(part 2):1357, 1981 (abstract)

    Google Scholar 

  62. Cowen AE, Korman MG, Hofmann AF, Cass OW: Metabolism of lithocholate in healthy man. I. Biotransformations and biliary excretion of intravenously administered lithocholate, lithocholyglycine, and their sulfates. Gastroenterology 69:59–66, 1975

    PubMed  Google Scholar 

  63. Cowen AE, Korman MG, Hofmann AF, Cass OW, Coffin SB: Metabolism of lithocholate in healthy man. II. Enterohepatic circulation. Gastroenterology 69:67–76, 1975

    PubMed  Google Scholar 

  64. Cowen AE, Korman MG, Hofmann AF, Thomas PJ: Metabolism of lithocholate in healthy man. III. Plasma disappearance of radioactivity after intravenous injection of labeled lithocholate and its derivatives. Gastroenterology 69:77–82, 1975

    PubMed  Google Scholar 

  65. Czygan P, Seitz H, Waldherr R, Stiehl A, Kommerell B: Untersuchungen zur kokarzinogenen Wirkung von Ursodeoxycholsäure and Chenodeoxycholsäure beim Dimethylhydrazine-induzierten Kolonkarzinom der Ratte. Z Gastroenterol 19:87, 1981 (abstract)

    Google Scholar 

  66. Czygan P, Seitz H, Weber E, Stiehl A, Kommerell B: DNA synthesis in the rat colon: Influence of chenodeoxycholic acid and ursodeoxycholic acid. Gastroenterology 80(part 2):1131, 1981 (abstract)

    Google Scholar 

  67. Czygan P, Stiehl A, Raedsch R, Männer Ch, Kommerell B: Cholesterol gallstone dissolution rate with urso and combined urso-cheno treatment. 16th meeting of the European Association for the Study of the Liver, Lisbon, Sept 3–5, 1981, p 152 (abstract)

  68. Dancygier H, Schneider M, Leuschner U, Hubner K: Effect of chenodeoxycholic acid and ursodeoxycholic acid on liver cell proliferation in the rat—a morphometric and histoautoradiographic study. Ital J Gastroenterol 12:44–48, 1980

    Google Scholar 

  69. Danzinger RG, Hofmann AF, Schoenfield LJ, Thistle JL: Dissolution of cholesterol gallstones by chenodeoxycholic acid. N Engl J Med 286:1–8, 1972

    PubMed  Google Scholar 

  70. Debongnie JG, Phillips SF: Capacity of the human colon to absorb fluid. Gastroenterology 74:698–703, 1978

    PubMed  Google Scholar 

  71. Delmont J, Rampal P, Math M, Faure X, Renson M: Traitement de la lithiase biliaire par l'acide ursodéoxycholique. Sem Hop Paris 56:1613–1616, 1980

    PubMed  Google Scholar 

  72. Dew MJ, Hawker PC, Nutter S, Allan RN: Human intestinal sulfation of lithocholate: a new site for bile acid metabolism. Life Sci 27:317–323, 1980

    PubMed  Google Scholar 

  73. Dietschy JM, Salomon HS, Siperstein MD: Bile acid metabolism. I. Studies on the mechanisms of intestinal transport. J Clin Invest 45:832–846, 1966

    PubMed  Google Scholar 

  74. Dolgin SM, Schwartz JS, Kressel HY, Soloway RD, Wallace TM, Trotman BW, Soloway AS, Good LI: Identification of patients with cholesterol or pigment gallstones by discriminant analysis of radiographic features. N Engl J Med 304:808–811, 1981

    PubMed  Google Scholar 

  75. Dowling RH: Medical treatment of gallstones with CDCA and UDCA.In Bile Acids and Lipids, G Paumgartner, A Stiehl, W Gerok (eds). Lancaster England, MTP Press, 1981, pp 329–339

    Google Scholar 

  76. Dowling RH, Hofmann AF, Barbara L (eds): Workshop on Ursodeoxycholic Acid. Baltimore, University Park Press, 1979

    Google Scholar 

  77. Dowling RH, Mack E, Small DM: Effects of controlled interruption of the enterohepatic circulation of bile salts by biliary diversion and by ileal resection on bile salt secretion, synthesis, and pool size in the rhesus monkey. J Clin Invest 49:232–242, 1970

    PubMed  Google Scholar 

  78. Dumont M, Erlinger S, Uchman S: Hypercholeresis induced by ursodeoxycholic acid and 7-ketolithocholic acid in the rat: possible role of bicarbonate transport. Gastroenterology 79:82–89, 1980

    PubMed  Google Scholar 

  79. Edenharder R, Knaflic T: Epimerization of chenodeoxycholic acid to ursodeoxycholic acid by human intestinal lecithinase-lipase-negativeClostridia. J Lipid Res 22:652–658, 1981

    PubMed  Google Scholar 

  80. Emerman S, Javitt NB: Metabolism of taurolithocholic acid in the hamster. J Biol Chem 242:661–664, 1967

    PubMed  Google Scholar 

  81. Fedorowski T, Salen G, Colallilo A, Tint GS, Mosbach EH, Hall JC: Metabolism of ursodeoxycholic acid in man. Gastroenterology 73:1131–1137, 1977

    PubMed  Google Scholar 

  82. Fedorowski T, Salen G, Tint GS, Mosbach E: Transformation of chenodeoxycholic and ursodeoxycholic acid by human intestinal bacteria. Gastroenterology 77:1068–1073, 1979

    PubMed  Google Scholar 

  83. Fedorowski T, Salen G, Zaki G, Shefer S, Mosbach EH: Comparative effects of ursodeoxycholic acid and chenodeoxycholic acid in the rhesus monkey. Biochemical and ultrastructural studies. Gastroenterology 74:75–81, 1978

    PubMed  Google Scholar 

  84. Fisher RL, Anderson D, Boyer JL, Ishak K, Klatskin G, Lachin F, Phillips MJ: A prospective morphologic evaluatin of hepatic toxicity of chenodeoxycholic acid (CDCA) in patients with cholelithiasis. Gastroenterology 80(part 2):1332, 1981 (abstract)

    Google Scholar 

  85. Forker EL: Mechanisms of hepatic bile formation. Annu Rev Physiol 39:323–347, 1977

    PubMed  Google Scholar 

  86. Francavilla A, Amoruso A, Panella C, Doronzo F, Sansonno D, Frigerio G: Effectiveness of ursodeoxycholic acid administered in a single bedtime dose to patients with radiolucent gallstones. 16th meeting of the European Association for the Study of the Liver, Lisbon, Sept 3–5, 1981, p 173 (abstract)

  87. Frigerio G: Ursodeoxycholic acid (UDCA) in the treatment of dyspepsia: report of a multicenter controlled trial. Curr Ther Res 26:214–224, 1979

    Google Scholar 

  88. Fromm H, Carlson GL, Hofmann AF, Farivar S, Amin P: Metabolism in man of 7-ketolithocholic acid: precursor of cheno- and ursodeoxycholic acids. Am J Physiol 239:G161-G166, 1980

    PubMed  Google Scholar 

  89. Fromm H, Erbler HC, Eschler A, Schmidt FW: Veränderungen des Gallensäurenstoffwechsels unter der Behandlung mit Chenodesoxycholsäure. Untersuchungen zur Bedeutung des Auftretens von Ursodesoxycholsäure fur die Gallensteinauflösung. Klin Wochenschr 54:1125–1131, 1976

    PubMed  Google Scholar 

  90. Gadacz TR, Allan RN, Mack E, Hofmann AF: Impaired lithocholate sulfation in the rhesus monkey: a possible mechanism for chenodeoxycholate toxicity. Gastroenterology 70:1125–1129, 1976

    PubMed  Google Scholar 

  91. Gasbarrini G, Bonvicini F, Ianiro G, Bolondi L, De Felicis S, Tovoli S, Arienti V, Labo G: Controllo dei parametri clinici, umorali, radiologici ed ultrasonografici in pazienti trattati con acido ursodesossicolico per calcolosi colesterinica. Risultati a breve e medio termine. 5th International Symposium on Bile Acids, Cortina d'Ampezzo Italy, March 1979, pp 42–43 (abstract)

  92. Gasbarrini G, Bonvicini F, Riario-Sforza G, Ianiro G, Bernardi M, Corazza GR, DiCosmo C, Cassiani R, Gabriele P: Laboratory and clinical investigations after ursodeoxycholic acid treatment. Preliminary observations on uric acid excretion in bile. Ital J Gastroenterol 10(Suppl 1):70–72, 1978

    Google Scholar 

  93. Gilmore IT, Barnhart JL, Hofmann AF, Erlinger S: Different effects of chenodeoxycholyl taurine and ursodeoxycholyl taurine on the biliary secretion of sucrose, cholesterol and lecithin in the unanesthetized dog. Am J Physiol (in press)

  94. Gilmore IT, Stokes K, Hofmann AF, Gurantz D, Lorenzo D: Differing acute effects of chenodeoxycholyl conjugates and ursodeoxycholyl conjugates on biliary phospholipid and cholesterol secretion in gallstone patients. American Association for the Study of Liver Diseases, Chicago, Nov 1980, p 22 (abstract)

    Google Scholar 

  95. Gilmore IT, Thompson RPA: Plasma clearance of oral and intravenous cholic acid in subjects with and without chronic liver disease. Gut 21:123–127, 1980

    PubMed  Google Scholar 

  96. Goldin B, Gorbach SL: Colon cancer connection: Beef, bran, bile and bacteria. Viewpoints Dig Dis 10:No. 3, 1978

  97. Gordon SJ, Kinsey MD, Magen JS, Joseph RE, Kowlessar OD: Structure of bile acids associated with secretion in the rat cecum. Gastroenterology 77:38–44, 1979

    PubMed  Google Scholar 

  98. Götz R, Raedsch R, Walker S, Stiehl A, Czygan P, Kommerell B: Uptake of taurochenodeoxycholic acid and tauroursodeoxycholic acid by isolated rat liver cells. VI International Bile Acid Meeting, “Bile Acids and Lipids.” Frieburg, W. Germany, Oct 1980, pp 98–99 (abstract)

  99. Greim H, Trülzsch D, Czygan P, Rudick J, Hutterer F, Schaffner F, Popper H: Mechanism of cholestasis. 6. Bile acids in human livers with or without biliary obstruction. Gastroenterology 63:846–850, 1972

    PubMed  Google Scholar 

  100. Greim H, Trülzsch D, Roboz J, Dressler K, Czygan P, Hutterer F, Schaffner F, Popper H: Mechanism of cholestasis. 5. Bile acids in normal rat livers and in those after bile duct ligation. Gastroenterology 63:837–845, 1972

    PubMed  Google Scholar 

  101. Grundy SM, Metzger AL: A physiologic method for estimation of hepatic secretion of biliary lipids in man. Gastroenterology 62:1200, 1972

    PubMed  Google Scholar 

  102. Gurantz D, Gilmore IT, Hofmann AF, DiPietro R: Acute effects of individual bile acids given enterally on biliary lipid secretion in the hamster. Gastroenterology 78(part 2):1307, 1980 (abstract)

    Google Scholar 

  103. Gurantz D, Gilmore It, Hofmann AF, Kozmary S: Biliary lipid secretion in the hamster: Greater cholesterol secretion induced by unconjugated bile acids. Hepatology 1:513, 1981 (abstract)

    Google Scholar 

  104. Gustafsson B, Midtvedt T, Norman A: Isolated fecal microorganisms capable of 7α-dehydroxylating bile acids. J Exp Med 123:413–432, 1966

    PubMed  Google Scholar 

  105. Hammarsten O: Untersuchungen über die Gallen einiger Polarthiere. I. Ueber die Galle des Eisbären. I Abschnitt. Hoppe-Seyler's Z Physiol Chem 32:435–466, 1901. II. Abschnitt. 36:525–555, 1902

    Google Scholar 

  106. Handelsman B, Bonorris GG, Marks W, Schoenfield LJ: Enrichment of bile with taurine-conjugated ursodeoxycholic acid in hamsters. Hepatology 1:24A, 1981 (abstract)

    Google Scholar 

  107. Hansen W, Schulz G: Binding of bile acidsin vitro by cholestyramine, colestipol and charcoal. VI International Bile Acid Meeting. Freiburg, W. Germany, Oct 1980, p 93 (abstract)

  108. Harada S, Hisatsugu T: Studies on calcified structure in human cholesterol gallstone. Fukuoka Acta Med 70:732–736, 1979

    PubMed  Google Scholar 

  109. Hardison WGM, Weiner RG, Hatoff DE: Determinants of bile acidT m in the rat. Gastroenterology 78(part 2):1307, 1980 (abstract)

    Google Scholar 

  110. Harris CC, Mulvihill JJ, Thorgeirsson SS, Minna JD: Individual differences in cancer susceptibility. Ann Intern Med 92:809–825, 1980

    PubMed  Google Scholar 

  111. Hartmann W, Paulini K, Goebell H: Light and electron microscopy of human liver before and during chenodeoxycholic acid therapy. Hepato-Gastroenterol 27:91–98, 1980

    Google Scholar 

  112. Haslewood GAD: The Biological Importance of Bile Salts. Amsterdam, North-Holland Publishing Co, 1978

    Google Scholar 

  113. Hatanaka H, Kawaguchi A, Hayakawa S, Katsuki H: Structural specificity of bile acid for inhibition of sterol synthesis in cell-free extracts of yeast. Biochim Biophys Acta 270:397–406, 1972

    PubMed  Google Scholar 

  114. Hatoff DE, Hardison WGM: Induced synthesis of alkaline phosphatase by bile acids in rat liver cell culture. Gastroenterology 77:1062–1067, 1979

    PubMed  Google Scholar 

  115. Hatoff DE, Hardison WGM: Bile acids modify alkaline phosphatase induction and bile secretion pressure after bile duct obstruction in the rat. Gastroenterology 80:666–672, 1981

    PubMed  Google Scholar 

  116. Haubrich WS: Getting rid of gallstones without surgery. J Am Med Assoc 231:747–748, 1975

    Google Scholar 

  117. Hayakawa S: Microbiological transformation of bile acids. Adv Lipid Res 11:143–192, 1973

    Google Scholar 

  118. Hegardt FG, Dam H: The solubility of cholesterol in aqueous solutions of bile salts and lecithin. Z Ernährungswissenschaft 10:223–233, 1971

    Google Scholar 

  119. Hellstrom K, Sjovall J: On the origin of lithocholic and ursodeoxycholic acids in man. Bile acids and steroids 106. Acta Physiol Scand 51:218–223, 1961

    PubMed  Google Scholar 

  120. Higashi H, Setoguchi T, Katsuki T: Interconversion between chenodeoxycholic and ursodeoxycholic in anaerobic cultures of intestinal bacteria and reduction of 7-ketolithocholic acid to both bile acids. Acta Hepatol Jpn 19:803, 1978

    Google Scholar 

  121. Hikasa Y, Nagase M, Tanimura H, Shioda R, Setoyama M, Kobayashi N, Mukaihara S, Kamata T, Naruyama K, Kato H, Mori K, Soloway RD: Epidemiology and etiology of gallstones. Arch Jpn Chir 49:555–571, 1980

    Google Scholar 

  122. Hill MF: Fecal steroids in the etiology of large bowel cancer.In The Bile Acids. Chemistry, Physiology, and Metabolism. Volume 3: Pathophysiology, PP Nair, D Kritchevsky (eds). 1976, pp 169–199

  123. Hirano S, Masuda N: Epimerization of the 7-hydroxy group of bile acids by the combination of two kinds of microorganisms with 7α- and 7β-hydroxysteroid dehydrogenase activity, respectively. J Lipid Res 22:1060–1068, 1981

    PubMed  Google Scholar 

  124. Hirano S, Masuda N, Oda H:In vitro transformation of chenodeoxycholic acid and ursodeoxycholic acid by human intestinal flora, with particular reference to the mutual conversion between the two bile acids. J Lipid Res 22:735–743, 1981

    PubMed  Google Scholar 

  125. Hisadome T, Nakama T, Itoh H, Furusawa T: Physical-chemical properties of chenodeoxycholic acid and ursodeoxycholic acid. Gastroenterol Jpn 15:257–263, 1980

    PubMed  Google Scholar 

  126. Hofmann AF: Studies on the bioavailability of Ursofalk. Unpublished observations

  127. Hofmann AF, Hoffman NE: Measurement of bile acid kinetics by isotope dilution in man. Gastroenterology 67:314–323, 1974

    PubMed  Google Scholar 

  128. Hofmann AF, Klein PD: Characterization of bile acid metabolism in man using bile acids labelled with stable isotopes.In Stable Isotopes, TA Baillie (ed). Baltimore, University Park Press, 1978, pp 189–204

    Google Scholar 

  129. Hofmann AF, Thistle JL, Klein PD, Szczepanik PA, Yu PYS: Chenotherapy for gallstone dissolution. II. Induced changes in bile composition and gallstone response. J Am Med Assoc 239:1138–1144, 1978

    Google Scholar 

  130. Horak W, Polterauer P, Renner F, Rauhs R, Muhlbacher F, Funovics J, Weidhofer J: Effect of different bile acids on cholesterol and phospholipid secretion in the isolated perfused baboon liver. VI International Bile Acid Meeting, “Bile Acids and Lipids.” Freiburg, W. Germany, Oct 1980, p 145 (abstract)

  131. Hoshita T, Kono M, Matsumoto M, Uchiyama M, Kuramoto T: Metabolism of bile acids. I. Absorption, distribution, excretion and metabolism of ursodeoxycholic acid. Yakugaku Zasshi (J Pharm Soc Jpn) 94:1196–1205, 1974

    PubMed  Google Scholar 

  132. Hosono H, Iwasaki M: Acute toxicity and hemolysis studies of ursodeoxycholic acid in rats and mice. Kiso to Rinsho (Clin Rep) 9:3159–3166, 1975

    Google Scholar 

  133. Igimi H: Ursodeoxycholate—a common bile acid in gall bladder bile of Japanese subjects. Life Sci 18:993–1000, 1976

    PubMed  Google Scholar 

  134. Igimi H, Carey MC: Cholesterol monohydrate (ChM) gallstones dissolved faster in chenodeoxycholate (CDC)-rich bile than in ursodeoxycholate (UDC)-rich bile. Gastroenterology 78(part 2):1186, 1980 (abstract)

    Google Scholar 

  135. Igimi H, Carey MC: pH-solubility relations of chenodeoxycholic and ursodeoxycholic acids: Physical-chemical basis for dissimilar solution and membrane phenomena. J Lipid Res 21:72–90, 1980

    PubMed  Google Scholar 

  136. Igimi H, Carey MC: Cholesterol gallstone dissolution in bile: Dissolution kinetics of crystalline (anhydrate and monohydrate) cholesterol with chenodeoxycholate, ursodeoxycholate, and their glycine and taurine conjugates. J Lipid Res 22:254–270, 1981

    PubMed  Google Scholar 

  137. Igimi H, Tamesue N, Ikejiri Y, Shimura H: Ursodeoxycholate—in vitro cholesterol solubility and changes of composition of human gallbladder-bile after oral treatment. Life Sci 21:1373–1380, 1977

    PubMed  Google Scholar 

  138. Isselbacher KJ: A medical treatment for gallstones? N Engl J Med 286:40–42, 1972

    PubMed  Google Scholar 

  139. Isselbacher KJ: Chenodiol for gallstones: Dissolution or disillusion? Ann Intern Med 95:377–379, 1981 (editorial)

    PubMed  Google Scholar 

  140. Iwamura K: Clinical studies on cheno- and ursodeoxycholic acid treatment for gallstone dissolution. Hepato-Gastroenterol 27:26–34, 1980

    Google Scholar 

  141. Iwasaki T: Über die Konstitution der Urso-desoxycholsäure. Z Physiol Chem 244:181–193, 1936

    Google Scholar 

  142. Johnston CG, Nakayama F: Solubility of cholesterol and gallstones in metabolic material. Arch Surg 75:436–442, 1957

    Google Scholar 

  143. Jorge A, Milutin C, Gutierrez L, Burgos M: Ultrastrukturelle Untersuchungen der Leber bei Patienten mit Cholesteringallensteinen unter Chenodesoxycholsäure-therapie. Leber Magen Darm 9:200–204, 1979

    PubMed  Google Scholar 

  144. Kajiyama G, Maruhashi A, Mizuno T, Yamada K, Kawamoto T, Fujiyama M, Kubota S, Sasaki H, Oyamada K, Nakao S, Miyoshi A: Treatment of gallstones with chenodeoxy- and ursodeoxycholic acid; the influence of presence or absence of hyperlipidemia on gallstone dissolution. Hiroshima J Med Sci 28:67–71, 1979

    PubMed  Google Scholar 

  145. Kameda H, Chairman, Tokyo Cooperative Gallstone Study Group: Efficacy and indications of ursodeoxycholic acid treatment for dissolving gallstones. A multi-center doubleblind trial. Gastroenterology 78:542–548, 1980

    PubMed  Google Scholar 

  146. Kanazawa T, Shimazaki A, Sato T, Hoshino T: Studies on the synthesis of ursodeoxycholic acid. Nippon Kagaku Zasshi (Jpn J Chem) 76:297–301, 1955 (summary in Chem Abst 51:17965, 1957)

    Google Scholar 

  147. Kawasaki H, Yamanishi Y, Kishimoto Y, Hirayama C, Ikawa S, Kuchiba K, Kondo T: Abnormality of oral ursodeoxycholic acid tolerance test in the Dubin-Johnson syndrome. Clin Chim Acta 112:13–19, 1981

    PubMed  Google Scholar 

  148. Kay RM: Effects of diet on the fecal excretion and bacterial modification of acidic and neutral steroids, and implications for colon carcinogenesis. Cancer Res 41:3774–3777, 1981

    PubMed  Google Scholar 

  149. Kelsey MI, Pienta RJ: Transformation of hamster embryo cells by cholesterol-α-epoxide and lithocholic acid. Cancer Lett 6:143–149, 1979

    PubMed  Google Scholar 

  150. Kimura T: Cytotoxicity of bile acids on cultured cells. Jpn J Gastroenterol 77:185–194, 1980

    Google Scholar 

  151. Kimura T, Shimamura M, Yamaguchi A, Katayama T, Kurita T, Tanaka A: Solubilization of cultured cell membrane by bile acids. Acta Hepatol Jpn 22:1–7, 1981

    Google Scholar 

  152. Kitani K, Kanai S: Tauroursodeoxycholate prevents taurocholate induced cholestasis. Hepatology 1:33B, 1981 (abstract)

    Google Scholar 

  153. Kitani K, Kanai S: Biliary transport maximum of tauroursodeoxycholate is twice as high as that of taurocholate in the rat. Life Sci 29:269–275, 1981

    PubMed  Google Scholar 

  154. Koch MM, Giampieri MP, Lorenzini I, Jezequel AM, Orlandi F: Effect of chenodeoxycholic acid on liver structure and function in man: A stereological and biochemical study. Digestion 20:8–21, 1980

    PubMed  Google Scholar 

  155. Koch MM, Giamperi MP, Lorenzini I, Jezequel AM, Orlandi F: Effect of ursodeoxycholic acid on liver structure in man: Quantitative data. Gastroenterol Clin Biol 4:560–568, 1980

    PubMed  Google Scholar 

  156. Kulkarni MS, Heidepriem PM, Yielding KL: Production by lithocholic acid of DNA strand breaks in L1210 cells. Cancer Res 40:2666–2669, 1980

    PubMed  Google Scholar 

  157. Kurtz W, Leuschner U, Althoff P, Frerichs K, Maurer T, Rietbrock N: Der Einfluss oraler Cholelitholytika auf die Resorption von Digitoxin. Z Gastroenterol 19:239, 1981 (abstract)

    Google Scholar 

  158. Kurtz W, Leuschner U, Klump P, Schneider M, Bergk G, Erb W, Strohm WD: Bile acids in tumor tissue, intestinal mucosa, serum, and feces of patients with colorectal carcinoma. Gastroenterology 78:1201, 1980 (abstract)

    Google Scholar 

  159. Kurtz W, Leuschner U, Scholz G, Michel J, Strohm WD: Differences in chenodeoxycholic acid and ursodeoxycholic acid influence on rat small intestinal wall bile acids. Ital J Gastroenterol 12:331–334, 1980

    Google Scholar 

  160. Kurtz W, Leuschner U, Strohm WD, Banzer W, Franz J: Unterschiedlicher Einfluss von Chenodeoxycholsäure (CDC) and Ursodeoxycholsäure (UDC) auf die Gallensäuren in Kolonwand und Koloninhalt der Ratte. Z Gastroenterol 19:10, 1981 (abstract)

    Google Scholar 

  161. Kutz K, Schulte A: Effectiveness of ursodeoxycholic acid in gallstone therapy. Gastroenterology 73:632, 1977 (letter)

    PubMed  Google Scholar 

  162. Kutz K, Schulte A: Effect of ursodeoxycholic acid on bile supersaturated with cholesterol in patients pretreated with clofibrate. Z Gastroenterol 19:231–236, 1981

    PubMed  Google Scholar 

  163. Lageron A, Levy V-G, Saffroy M, Verthier N: Étude histologique et histoenzymologique du foie. II. Dans la lithiase vésiculaire traitée par l'acide chénodésoxycholique. Acta Histochem 65:8–14, 1979

    PubMed  Google Scholar 

  164. LaRusso NF, Hoffman NE, Hofmann AF, Northfield TC, Thistle JL: Effect of primary bile acid ingestion on bile acid metabolism and biliary lipid secretion in gallstone patients. Gastroenterology 69:1301–1314, 1975

    PubMed  Google Scholar 

  165. LaRusso NF, Korman MG, Hoffman NE, Hofmann AF: Dynamics of the enterohepatic circulation of bile acids. Postprandial serum concentrations of conjugates of cholic acid in health, cholecystectomized patients, and patients with bile acid malabsorption. N Engl J Med 291:689–692, 1974

    PubMed  Google Scholar 

  166. LaRusso NF, Thistle JL: Effect of ursodeoxycholic acid and chenodeoxycholic acid absorption in patients with cholelithiasis.In Bile Acids and Lipids, G Paumgartner, A Stiehl, W Gerok (eds). Lancaster, England, MTP Press, 1981, pp 141–142

    Google Scholar 

  167. LaRusso NF, Thistle JL: Ursodeoxycholic acid ingestion after ileal resection: effect on biliary bile acid and lipid composition. Dig Dis Sci 26:705–709, 1981

    PubMed  Google Scholar 

  168. Leading article: Dissolving hopes for gallstone dissolution? Lancet 2:905–906, 1981

    Google Scholar 

  169. Lee D, Bonorris G, Cohen H, Gilmore C, Marks J, Schoenfield LJ: Effect of ursodeoxycholic acid on bile acid kinetics and hepatic lipid secretion. Hepatology 1:36A, 1981 (abstract)

    Google Scholar 

  170. Leiss O, von Bergmann K: Einfluss von Cheno- and Ursodeoxycholsäure auf biliäre Lipidsekretion und Serumlipoproteinkonzentration. Dtsch Ges Innere Med 292:April, 1981 (abstract)

  171. Leiss O, Bosch T, von Bergmann K: Effects of bile acid feeding on lipoprotein concentration, change in cholesterol synthesis and biliary lipid secretion in patients with radiolucent gallstones.In Bile Acids and Lipids, P. Baumgartner, A Stiehl, W Gerok (eds). Lancaster, England, MTP Press, 1981, pp 247–253

    Google Scholar 

  172. Leuschner U: Bilanz der medikamentösen Gallenstein Auflösung. Med Klin 76:232–234, 1981

    PubMed  Google Scholar 

  173. Leuschner U, Czygan P, Liersch M, Fröhling W, Stiehl A: Morphologische Untersuchungen zur Toxizität sulfatierter und nichtsulfatierter Lithocholsäure an der perfundierten Rattenleber. Z Gastroenterol 15:246–253, 1977

    PubMed  Google Scholar 

  174. Leuschner U, Leuschner M, Hübner K: Gallstone dissolution in patients with chronic active hepatitis. Gastroenterology 80(part 2):1208, 1981 (abstract)

    Google Scholar 

  175. Leuschner U, Leuschner M, Strohm WD, Kurtz W: Untersuchungen zur Wirksamkeit von Ursodeoxycholsäure und Chenodeoxycholsäure bei vergleichbaren Kollectiven von Gallensteinpatienten. Z Gastroenterol 19:168, 1981

    PubMed  Google Scholar 

  176. Leuschner U, Schneider M, Korte L: Der Einfluss von Chenodesoxycholsäure und Ursodesoxycholsäure auf die Leberstruktur der Ratte. Z Gastroenterol 17:244–255, 1979

    PubMed  Google Scholar 

  177. Levitt RE, Lafsky RD, Soloway RD, Touchstone JC, Trotman BW: Prediction of gallstone type by bile acid analysis of human gallbladder bile. Gastroenterology 80(part 2):1211, 1981 (abstract)

    Google Scholar 

  178. Lillemoe KD, Harmon JW, Gadacz TR, Hofmann AW, Weichbrod R: Effects of taurochenodeoxycholic and tauroursodeoxycholic acids on gastric mucosa. Gastroenterology 80(part 2):1214, 1981 (abstract)

    Google Scholar 

  179. Linos DA, Beard CM, O'Fallon WM, Dockerty MB, Beart RW Jr, Kurland LT: Cholecystectomy and carcinoma of the colon. Lancet 2:379–381, 1981

    PubMed  Google Scholar 

  180. Lipkin M, Sherlock P, DeCosse JJ: Risk factors and preventive measures in the control of cancer of the large intestine. Curr Prob Cancer 14(10):000, 1980

    Google Scholar 

  181. MacDonald IA, Hutchison DM, Forrest TP: Formation of urso- and ursodeoxycholic acids from primary bile acids byClostridium absonum. J Lipid Res 22:458–466, 1981

    PubMed  Google Scholar 

  182. Mahowald TA, Wu Yin M, Matschiner JT, Hsia SL, Doisy EA Jr, Elliott WH, Doisy EA: Bile acids. VIII. Metabolism of 7-ketolithocholic acid-24-C14 in the rat. J Biol Chem 230:581–588, 1958

    PubMed  Google Scholar 

  183. Makino I, Nakagawa S: Changes in biliary lipid and biliary bile acid composition in patients after administration of ursodeoxycholic acid. J Lipid Res 19:723–728, 1979

    Google Scholar 

  184. Makino I, Shinozaki K, Yoshino K, Nakagawa S: Dissolution of cholesterol gallstones by ursodeoxycholic acid. Jpn J Gastroenterol 72:690–802, 1975

    Google Scholar 

  185. Marigold JH, Gilmore IT, Thompson RPH: Direct hepatic extraction of bile acids in subjects with and without liver disease. VI International Bile Acid Meeting. “Bile Acids and Lipids,” Freiburg, W. Germany, Oct 1980, p 156 (abstract)

  186. Marteau C, Reynier MO, Mathieu S, Salasc B, Mule A, Montet JC, Gerolami A: L'état de la circulation enterohepatique influence-t'il l'action immediate de differents sels biliares sur la saturation de la bile en cholesterol. Gastroenterol Clin Biol 4:79A, 1980 (abstract)

    Google Scholar 

  187. Matern S, Schill A, Schubert P, Lehnert W, Tietjen K, Schulte-Kellinghaus M, Liomin E, Matern H, Gerok W: Bioverfügbarkeit von Ursodeoxycholsäure bei der Gallensteinauflösung des Menschen: Massenspektrometrische Studien mit13C-markierter Ursodeoxycholsäure. Z Gastroenterol 19:11, 1981 (abstract)

    Google Scholar 

  188. Matern S, Tietjen KG, Fackler O, Hinger K, Herz R, Gerok W: Bioavailability of ursodeoxycholic acid in man: Studies with a radioimmunoassay for ursodeoxycholic acid.In Biological Effects of Bile Acids, G Paumgartner, A Stiehl, W Gerok (eds). Lancaster, England, MTP Press, 1989, pp 99–102

    Google Scholar 

  189. Maton PN, Dowling RH: Hepatic cholesterol synthesis in cholelithiasis: role of HMGCoA reductase in response to and resistance to medical therapy.In Biological Effects of Bile Acids, G Paumgartner, A Stiehl, W Gerok (eds). Lancaster, England, MTP Press, 1979, pp 91–98

    Google Scholar 

  190. Maton PN, Ellis HJ, Higgins MJP, Dowling RH: Hepatic HMGCoA reductase in human cholelithiasis: effects of chenodeoxycholic and ursodeoxycholic acids. Eur J Clin Invest 10:325–332, 1980

    PubMed  Google Scholar 

  191. Maton PN, Murphy GM, Dowling RH: Ursodeoxycholic acid treatment of gallstones. Dose-response study and possible mechanism of action. Lancet 2:1297–1301, 1977

    PubMed  Google Scholar 

  192. Matschiner JT, Mahowald TA, Elliott WH, Doisy EA Jr, Hsia, SL, Doisy EA: Bile acids I. Two new acids from rat bile. J Biol Chem 225:771–779, 1957

    PubMed  Google Scholar 

  193. Mazer NA, Carey MC, Kwasnick RF, Benedek G: Quasielastic light scattering studies of aqueous biliary lipid systems. Size, shape and thermodynamics of bile salt micelles. Biochemistry 18:3064–3075, 1979

    PubMed  Google Scholar 

  194. Maudgal DP, Kupfer RM, Bird R, Northfield TC: Best buy bile acid treatment for gallstones. Gut 21:T58, 1980

    Google Scholar 

  195. McSherry CK: The National Cooperative Gallstone Study Report: A surgeon's perspective. Ann Intern Med 95:379–380, 1981 (editorial)

    PubMed  Google Scholar 

  196. Meredith IJ, Hilson A, Murphy GM, Dowling RH: An explanation for bile acid mediated gastritis and the relief of dyspepsia with chenodeoxycholic acid (CDCA) and ursodeoxycholic acid (UDCA) therapy. Clin Sci 60:72, 1981

    Google Scholar 

  197. Möckel G: Erfahrungen mit der Medikamentösen Gallensteinauflösung. Hamburger Ärzteblatt 35:76–69, 1981

    Google Scholar 

  198. Mok HYI, von Bergmann K, Crouse JR, Grundy SM: Biliary lipid metabolism in obesity. Effects of bile acid feeding before and during weight reduction. Gastroenterology 76:556–567, 1979

    PubMed  Google Scholar 

  199. Mok HYI, Grundy SM: Cholesterol and bile acid absorption during bile acid therapy in obese subjects undergoing weight reduction. Gastroenterology 78:62–67, 1980

    PubMed  Google Scholar 

  200. Montet J-C, Carey MC: Comparaison des propriétés micellaires et tensioactives des acides chénodésoxycholique (CDC) et ursodésoxycholique (UDC) et de leurs tauro (T-) et glyco (G-) conjugués en solution diluée. Gastroenterol Clin Biol 4:92, 1980 (abstract).

    Google Scholar 

  201. Moskovitz M, White C, Barnett R, Stevens S, Russell E, Vargo D, Floch MH: Diet, fecal bile acids, and neutral sterols in carcinoma of the colon. Am J Dig Dis 23:746–751, 1979

    Google Scholar 

  202. Nakagawa S, Makino I, Ishizaki T, Dohi I: Dissolution of cholesterol gallstones by ursodeoxycholic acid. Lancet 2:367–369, 1977

    PubMed  Google Scholar 

  203. Nakamura H: Studies on the mechanism of the serum cholesterol lowering effect of ursodeoxycholic acid. Hepatic cholesterol biosynthesis and fecal excretion of end products of cholesterol metabolism. Nippon Shokakibio Gakkai Zasshi 62:55–64, 1965

    Google Scholar 

  204. Nakamura T, Ohkuni A, Yamanaka M: Effects of chenodeoxycholic acid (CDCA) and ursodeoxycholic acid (UDCA) to glucose transport in hamster small intestine,in vitro. A study on the mechanism of diarrhea due to CDCA therapy. Jpn J Gastroenterol 77:1355–1361, 1980

    Google Scholar 

  205. Nakano Y, Nakano K: Some cases of gallstones dissolved by bile acid preparations. J Natl Council Communal Hospitals 70:25–32, 1973

    Google Scholar 

  206. Nakayama F, Miyazaki K, Koga A: Effect of chenodeoxycholic and ursodeoxycholic acids on isolated human hepatocytes. Gastroenterology 78(part 2):1228, 1980 (abstract)

    Google Scholar 

  207. Narisawa T, Reddy BS, Weisburger JH: Effect of bile acids and dietary fat on large bowel carcinogenesis in animal models. Gastroenterol Jpn 13:206–212, 1978

    PubMed  Google Scholar 

  208. National Cancer Institute: Bioassay of lithocholic acid for possible carcinogenicity. Technical Report Series No. 175, 1979

  209. Ng PY, Hofmann AF: Tissue distribution of cholylglycine-1-14C in rats and hamsters with a bile fistula or bile duct ligation. Proc Soc Exp Biol Med 154:134–137, 1977

    PubMed  Google Scholar 

  210. Nigro ND, Campbell RL: Bile acids and intestinal cancer.In The Bile Acids. Chemistry, Physiology and Metabolism. Volume 3: Pathophysiology, PP Nair, D Kritchevsky (eds). New York, Plenum Press, 1976, pp 155–168

    Google Scholar 

  211. Northfield TC, Hofmann AF: Biliary lipid secretion in gallstone patients. Lancet 1:747–748, 1973

    Google Scholar 

  212. Northfield TC, Hofmann AF: Biliary lipid output during three meals and an overnight fast. I. Relationship to bile acid pool size and cholesterol saturation of bile in gallstone and control subjects. Gut 16:1–11, 1975

    PubMed  Google Scholar 

  213. Northfield TC, LaRusso NF, Hofmann AF, Thistle JL: Biliary lipid output during three meals and an overnight fast. II. Effect of chenodeoxycholic acid treatment in gallstone subjects. Gut 16:12–17, 1975

    PubMed  Google Scholar 

  214. Ohkubo H, Okuda K, Iida S, Makino I: Ursodeoxycholic acid tolerance test in patients with constitutional hyperbilirubinemias and effect of phenobarbital. Gastroenterology 81:126–135, 1981

    PubMed  Google Scholar 

  215. Okumura M, Tanikawa K, Chuman Y, Koji T, Nakagawa S, Nakamura Y, Iino H, Yamasaki S, Hisatsugu T (Kyushu Inter-Hospital Study Group for Gallstones): Clinical studies on dissolution of gallstones using ursodeoxycholic acid. Gastroenterol Jpn 12:469–475, 1977

    PubMed  Google Scholar 

  216. Ota M, Isobe J, Tsuji Y, Kuramoto T, Hoshita T: Metabolism of bile acids IV. Absorption, distribution, excretion and metabolism of orally administered ursodeoxycholic acid in rats. Hiroshima J Med Sci 26:233–251, 1977

    PubMed  Google Scholar 

  217. Ota M, Matsumoto N, Kuramoto T, Hoshita T: Metabolism of bile acids V. Metabolism of ursodeoxycholic acid in rhesus monkey. Hiroshima J Med Sci 26:253–262, 1977

    PubMed  Google Scholar 

  218. Ota M, Tsuji Y, Hoshita T: Metabolism of bile acids VII. Metabolism of ursodeoxycholic acid in female rats. Hiroshima J Med Sci 27:139–145, 1978

    PubMed  Google Scholar 

  219. Palmer RH: Bile acids, liver injury, and liver disease. Arch Intern Med 130:606–617, 1972

    PubMed  Google Scholar 

  220. Palmer RH, McSherry CK, May PS: Lithocholate metabolism in baboons ingesting chenodeoxycholic acid. Gastroenterology 72:1173, 1977 (abstract)

    Google Scholar 

  221. Park YH, Igimi H, Carey MC: Human cholesterol (ChM) gallstones dissolve as fast in simulated ‘urso’-rich bile as in ‘cheno’-rich bile. Gastroenterology 80(part 2):1248, 1981 (abstract)

    Google Scholar 

  222. Parquet M, Infante R: Pharmacokinetics and fecal excretion of metabolites after a single administration of ursodeoxycholic acid in man. VI International Bile Acid Meeting, “Bile Acids and Lipids,” Freiburg, W. Germany, Oct 1980, p 190 (abstract)

  223. Parquet M, Rey C, Groussard M, Infante R: Pharmacokinetics and metabolism of [14C]-ursodeoxycholic acid in the rat. Biochim Biophys Acta 665:299–305, 1981

    PubMed  Google Scholar 

  224. Pearlman BJ, Bonorris GG, Phillips MJ, Chung A, Vimadalal S, Marks JW, Schoenfield LJ: Cholesterol gallstone formation and prevention by chenodeoxycholic and ursodeoxycholic acids. A new hamster model. Gastroenterology 77:634–641, 1979

    PubMed  Google Scholar 

  225. Peters H, Keimes AM: Die Cholezystektomie als prädisponierender Faktor in der Genese des kolorektalen Karzinoms? Dtsch Med Wochenschr 104:1581–1583, 1979

    PubMed  Google Scholar 

  226. Pienta R: A hamster embryo cell model system for identifying carcinogens.In Carcinogens: Identification and Mechanisms of Action, AC Griffin, CR Shaw (eds). New York, Raven Press, 1979, pp 121–141

    Google Scholar 

  227. Pienta RJ, Poiley JA, Lebherz WB III: Morphological transformation of early passage golden Syrian hamster embryo cells derived from cryopreserved primary cultures as a reliablein vitro bioassay for identifying diverse carcinogens. Int J Cancer 19:642–655, 1977

    PubMed  Google Scholar 

  228. Podda M, Zuin M, Dioguardi ML, Festorazzi S, Dioguardi N: A combination of cheno- and ursodeoxycholic acid is more effective than either alone in reducing bile cholesterol saturation. Liver 1:165, 1981 (abstract)

    Google Scholar 

  229. Podda M, Zuin M, Dioguardi ML, Lesma S: Comparison of effects of cheno-, urso-deoxycholic acid and their combination on biliary lipids in obese patients with gallstones. Gastroenterology 80(part 2):1344, 1981 (abstract)

    Google Scholar 

  230. Podesta MT, Murphy GN, Sladen GE, Breuer NF, Dowling RH: Fecal bile acid excretion in diarrhea: Effect of sulfated and non-sulfated bile acids on colonic structure and function.In Biological Effects of Bile Acids, G Paumgartner, A Stiehl, W Gerok (eds). Lancaster, England, MTP Press, 1979, pp 245–256

    Google Scholar 

  231. Polli E, Inter-Hospital Clinical Research Group (GRRC): The effect of ursodeoxycholic acid (UDCA) on “dyspepsia” in patients with gallstones or other biliary tract anomalies. Curr Ther Res 26:230–233, 1979

    Google Scholar 

  232. Polli EE, Bianchi PA, Conte D, Sironi L: Treatment of radiolucent gallstones with CDCA or UDCA. A multicenter trial. Digestion 22:185–191, 1981

    PubMed  Google Scholar 

  233. Ponz de Leon M, Carulli N: The influence of bile acid pool composition on the regulation of cholesterol absorption.In Bile Acids and Lipids, G Paumgartner, A Stiehl, W Gerok (eds). Lancaster, England, MTP Press, 1981, pp 133–140

    Google Scholar 

  234. Ponz de Leon M, Carulli N, Loria P, Ioria R, Zironi F: Cholesterol absorption during bile acid feeding. Effect of ursodeoxycholic acid (UDCA) administration. Gastroenterology 78:214–219, 1980

    PubMed  Google Scholar 

  235. Ponz de Leon M, Carulli N, Loria P, Romano G, Zironi F: Effect of chenodeoxycholic acid (CDCA) and ursodeoxycholic acid (UDCA) on cholesterol absorption in man. Ital J Gastroenterol 12:222, 1980

    Google Scholar 

  236. Ponz de Leon M, Loria P, Carulli N, Murphy GM, Dowling RH: Clinical pharmacology of oral chenodeoxycholic acid. Eur J Clin Invest 10:261–271, 1980

    PubMed  Google Scholar 

  237. Pries JM, Sherman CA, Williams GC, Hanson RF: Hepatic extraction of bile salts in conscious dog. Am J Physiol 5:E191-E197, 1979

    Google Scholar 

  238. Raedsch R, Stiehl A, Czygan P, Götz R, Manner Ch, Walker S, Kommerell B: Increased glycine conjugation of biliary bile acids during treatment of gallstone patients with chenodeoxycholic acid or ursodeoxcholic acid: Effects on biliary cholesterol saturation.In Bile Acids and Lipids, G Paumgartner, A Stiehl, W Gerok (eds). Lancaster, England, MTP Press, 1981, pp 195–202

    Google Scholar 

  239. Raedsch R, Stiehl A, Götz R, Walker S, Kommerell B: Kinetics of cholesterol gallstone dissolution by glycocheno-, glyco-urso-deoxycholic acid, and mixtures of bothin vitro. Z Gastroenterol 19:159–163, 1981

    PubMed  Google Scholar 

  240. Rahban S, Bonorris GG, Marks JW, Chung A, Schoenfield LJ: The effect of hydroxy bile acids on intestinal secretion, cyclic nucleotides, and Na+−K+-ATPase. Am J Med Sci 279:141–146, 1980

    PubMed  Google Scholar 

  241. Raicht RF, Cohen BI, Sarwal A, Takashai M: Ursodeoxycholic acid. Effects on sterol metabolism in rats. Biochim Biophys Acta 531:1–8, 1978

    PubMed  Google Scholar 

  242. Reddy BS, Wynder EL: Metabolic epidemiology of colon cancer. Fecal bile acids and neutral sterols in colon cancer patients and patients with adenomatous polyps. Cancer 39:2533–2539, 1977

    PubMed  Google Scholar 

  243. Rewbridge AG: The disappearance of gallstone shadows following the prolonged administration of bile salts. Surgery 1:395–400, 1937

    Google Scholar 

  244. Reynier MO, Montet J-C, Crotte C, Marteau C, Gerolami A: Cholesterol absorption from mixed micelles.In vitro effects of taurocholate (TC), taurochenodeoxycholate (TCDC) and tauroursodeoxycholate (TUDC). VI International Bile Acid Meeting, “Bile Acids and Lipids.” Freiburg, W. Germany, 1980, p 85 (abstract)

  245. Reynier MO, Montet J-C, Gerolami A, Marteau C, Crotte C, Montet AM, Mathieu S: Comparative effects of cholic, chenodeoxycholic and ursodeoxycholic acids on micellar solubilization and intestinal absorption of cholesterol. J Lipid Res 22:467–473, 1981

    PubMed  Google Scholar 

  246. Roda A, Bazzoli F, Petronelli A, Aldini R, Festi D, Frabboni R: Intestinal cholesterol absorption during CDCA and UDCA administration in man. VI International Bile Acid Meeting, “Bile Acids and Lipids.” Freiburg, W. Germany, Oct 1980, p 128 (abstract)

  247. Roda E, Mazzella G, Roda A, Bazzoli F, Messale E, Morselli AM, Festi D, Aldini R, Barbara L: Effect of chenodeoxycholic acid and ursodeoxycholic acid administration on biliary lipid secretion in normal weight and obese gallstone patients.In Bile Acids and Lipids, G Paumgartner, A Stiehl, W Gerok (eds). Lancaster, England, MTP Press, 1991, pp 189–193

    Google Scholar 

  248. Roda E, Roda A, Sama C, Festi D, Mazzella G, Aldini R, Barbara L: Effect of ursodeoxycholic acid administration on biliary lipid composition and bile acid kinetics in cholesterol gallstone patients. Dig Dis Sci 24:123–128, 1979

    PubMed  Google Scholar 

  249. Ross PE, Pennington CR, Bouchier IAD: Gas-liquid chromatic assay of serum bile acids. Anal Biochem 80:458–465, 1977

    PubMed  Google Scholar 

  250. Ruppin DC, Dowling RH: Is recurrence inevitable on withdrawing treatment after complete dissolution with chenodeoxycholic (CDC) and ursodeoxycholic (UDC) acids? Gut 22:A432, 1981 (abstract)

    Google Scholar 

  251. Salen G, Colalillo A, Verga D, Bagan E, Tint GS, Shefer S: The effect of high and low doses of ursodeoxycholic acid on gallstone dissolution in humans. Gastroenterology 78:1412–1418, 1980

    PubMed  Google Scholar 

  252. Salen G, Fedorowski T, Colalillo A, Tint GS, Mosbach EH: The metabolism of ursodeoxycholic acid in man.In Bile Acid Metabolism in Health and Disease. G Paumgartner, A Stiehl (eds). Lancaster, England, MTP Press, 1979, pp 167–172

    Google Scholar 

  253. Salen G, Shefer S, Tint GS, Batta AK, Verga D: The metabolism of 7-ketolithocholic acid in man. VI International Bile Acid Meeting, “Bile Acids and Lipids.” Freiburg, W. Germany, Oct 1980, p 52 (abstract)

  254. Salen G, Tint GS, Eliav B, Deering N, Mosbach EH: Increased formation of ursodeoxycholic acid in patients treated with chenodeoxycholic acid. J Clin Invest 53:521–612, 1974

    Google Scholar 

  255. Salen G, Tint GS, Verga D, Shefer S: The metabolism of 7-ketolithocholic acid in man.In Bile Acids and Lipids. G Paumgartner, A Stiehl, W Gerok (eds). Lancaster, England, MTP Press, 1981, pp 97–101

    Google Scholar 

  256. Salvioli G, Igimi H, Carey MC: Crystalline cholesterol monohydrate (ChM) dissolves in ‘urso’-rich bile by both liquid crystalline and micellar mechanisms: A phase equilibria explanation and possible clinical relevance. Gastroenterology 80(part 2):1268, 1981 (abstract)

    Google Scholar 

  257. Salvioli G, Salati R: Faecal bile acid loss and bile acid pool size during short-term treatment with ursodeoxycholic and chenodeoxycholic acid in patients with radiolucent gallstones. Gut 20:698–704, 1979

    PubMed  Google Scholar 

  258. Salvioli G, Salati R, Fratalocchi A, Lugli R: Ursodeoxycholic acid therapy for radiolucent gallstone dissolution. Curr Ther Res 26:995–1004, 1979

    Google Scholar 

  259. Sama C, Lopez V, LaRusso NF, Thistle JL: Acute administration of ursodeoxycholic acid decreases biliary cholesterol secretion in man. American Association for the Study of Liver Disease, Chicago, Nov 1980, p 57 (abstract)

    Google Scholar 

  260. Sama C, Morselli AM, Bazzoli F, Roda A, Roda E, Barbara L: Bioavailability and pharmacology of UDCA in man. 5th International Symposium on Bile Acids, Cortina d'Ampezzo, Italy, March 1979 (abstract)

  261. Sarva RP, Fromm H, Carlson GL, Mendelow L, Ceryak S: Intracolonic conversion in man of chenodeoxycholic acid (CDC) to ursodeoxycholic acid (UDC) with and without formation of 7-ketolithocholic acid (KLC) as an intermediate. Gastroenterology 78 (part 2):1253, 1980 (abstract)

    Google Scholar 

  262. Sarva RP, Fromm H, Farivar S, Sembrat RF, Mendelow H, Shinozuka H, Wolfson SK: Comparison of the effects between ursodeoxycholic and chenodeoxycholic acids on liver function and structure and on bile acid composition in the rhesus monkey. Gastroenterology 79:629–636, 1980

    PubMed  Google Scholar 

  263. Schersten T, Lindblad L: Biliary cholesterol output during ursodeoxycholic acid secretion in man.In Biological Effects of Bile Acids, G Paumgartner, A Stiehl, W Gerok (eds.) Lancaster, England, MTP Press, 1979, pp 53–60

    Google Scholar 

  264. Schoenfield LJ, Lachin JM, National Cooperative Gallstone Study Group: Chenodiol (chenodeoxycholic acid) for dissolution of gallstones: The National Cooperative Gallstone Study. A controlled trial of efficacy and safety. Ann Intern Med 95:257–282, 1981

    PubMed  Google Scholar 

  265. Schölmerich J, Schmidt K, Kremer B, Becher M-S, Gerok W: Bile salts and the liver cell membrane. 16th Meeting of the European Association for the Study of the Liver, Lisbon, Sept 3–5, 1981, p 5

  266. Schwenk M, Hofmann AF, Carlson GL, Carter JA, Coulston F, Greim H: Bile acid conjugation in the chimpanzee: Effective sulfation of lithocholic acid. Arch Toxicol 40:109–118, 1978

    PubMed  Google Scholar 

  267. Shapero TF, Lee V, Wilson RS, Rosen IE, Fisher MM: A problem in the evaluation of gallstone dissolution. Gastroenterology 80(part 2):1348, 1981 (abstract)

    Google Scholar 

  268. Shimada K, Bricknell KS, Finegold SM: Deconjugation of bile acids by intestinal bacteria. Review of literature and additional studies. J Infect Dis 119:273–281, 1969

    Google Scholar 

  269. Shinozaki K: Pharmacokinetic study of oral ursodeoxycholic acid tolerance test. Acta Hepatol Jpn 20:782–794, 1979

    Google Scholar 

  270. Shoda M: Über die Ursodesoxycholsäure aus Bärengallen und ihre physiologische Wirkung. J Biochem 7:505–517, 1927

    Google Scholar 

  271. Silverman SJ, Andrews AW: Bile acids: Co-mutagenic activity in theSalmonella-mammalian-microsome mutagenicity test: Brief communication. J Natl Cancer Inst 59:1557–1559, 1977

    PubMed  Google Scholar 

  272. Sjovall J: The occurrence of 7β-hydroxylated bile acids in human bile. Bile acids and steroids 76. Acta Chem Scand 13:711–716, 1959

    Google Scholar 

  273. Stiehl A: Effects of chenodeoxycholic acid and ursodeoxycholic acid on bile acid and biliary lipid metabolism in patients with radiolucent gallstones. Correlation with efficacy and toxicity.In Bile Acids and Lipids G Paumgartner, A Stiehl, W Gerok (eds). Lancaster, England, MTP Press, 1981, pp 309–317

    Google Scholar 

  274. Stiehl A, Ast E, Czygan P, Fröhling W, Kommerell B: Zur Ursache erhöhter Serumtransaminasen nach Behandlung von Patienten mit Cholesteringallensteinen mit Chenodeoxycholsäure. Inn Med 3:75–80, 1976

    Google Scholar 

  275. Stiehl A, Czygan P, Kommerell B, Weis HG, Höltermuller KH: Urosodeoxycholic acid versus chenodeoxycholic acid. Comparison of their effects on bile acid and bile lipid composition in patients with cholesterol gallstones. Gastroenterology 75:1016–1020, 1978

    PubMed  Google Scholar 

  276. Stiehl A, Czygan P, Raedsch R: Sulphation lithocholate in patients during chenodeoxycholate treatment. A protective mechanism.In Advances in Bile Acid Research, S Matern, P Hackenschmidt, P Back, W Gerok (eds). Stuttgart, FK Schattauer, 1975, pp 347–350

    Google Scholar 

  277. Stiehl A, Raedsch R: Increasing sulfation of lithocholate in patients during chenodeoxycholate therapy. Digestion 10:323, 1974 (abstract)

    Google Scholar 

  278. Stiehl A, Raedsch R, Czygan P, Götz R, Männer C, Walker S, Kommerell B: Effects of biliary bile acid composition on biliary cholesterol saturation in gallstone patients treated with chenodeoxycholic acid and/or ursodeoxycholic acid. Gastroenterology 79:1192–1198, 1980

    PubMed  Google Scholar 

  279. Sue SO, Pearlman BJ, Marks JW, Bonorris GG, Varady P, Lachin JM, Schoenfield LJ: Lithocholate sulfation: A determinant of hypertransaminesia in chenodeoxycholate-treated gallstone patients. Gastroenterology 78:1324, 1980

    Google Scholar 

  280. Sugata F, Kobayashi A, Yamamura M, Shimizu M: Five year follow-up study on UDCA therapy for cholelithiasis with special reference to recurrence. XI International Congress of Gastroenterology, Hamburg, Germany, June 1980, E34.11 (abstract)

  281. Sugata F, Shimizu M: Retrospective studies on gallstone disappearance. Jpn J Gastroenterol 71:75–80, 1974

    Google Scholar 

  282. Takahashi H, Tozuka K, Miyashita K, Miyamoto K: Toxicity studies of ursodeoxycholic acid orally administered for three months in Wistar male rat. Kiso to Rinsho (Clin Rep) 9:3203–3208, 1975

    Google Scholar 

  283. Takahashi H, Tozuka K, Miyashita T, Miyamoto K: Chronic toxicity studies of ursodeoxycholic acid orally administered for six months in Wistar male rat. Kiso to Rinsho (Clin Rep) 9:3209–3222, 1975

    Google Scholar 

  284. Takahashi H, Tozuka K, Miyashita T, Usui K, Miyamoto K: Subacute toxicity studies of orally administered ursodeoxycholic acid in Wistar rat. Kiso to Rinsho (Clin Rep) 9:3167–3181, 1975

    Google Scholar 

  285. Takahashi H, Tozuka K, Miyashita T, Usui K, Miyamoto K: Subacute toxicity studies of intraperitoneally administered ursodeoxycholic acid in Wistar rat. Kiso to Rinsho (Clin Rep) 9:3183–3202, 1975

    Google Scholar 

  286. Takahashi H, Tozuka K, Miyashita T, Usui K, Miyamoto K: Influence of ursodeoxycholic acid administered during pregnancy on the development of foetus and postnatal growth in rats and mice. Kiso to Rinsho (Clin Rep) 9:3223–3242, 1975

    Google Scholar 

  287. Tangedahl TN, Thistle JL, Hofmann AF, Matseshe JW: Effect of β-sitosterol alone or in combination with chenic acid on cholesterol saturation of bile and cholesterol absorption in gallstone patients. Gastroenterology 76:1341–1346, 1979

    PubMed  Google Scholar 

  288. Tashiro A: Oral ursodeoxycholic acid tolerance test for patients with hepatobiliary disease. Acta Hepatol Jpn 20:369–375, 1979

    Google Scholar 

  289. Tateyama T, Matsushiro T: Bile acid composition affecting cholesterol dissolution rate: A use of multiple regression analysis. Tohoku J Exp Med 133:467–475, 1981

    PubMed  Google Scholar 

  290. Thistle JL: Treatment of bile duct stones.In Bile Acids and Lipids, G Paumgartner, A Stiehl, W Gerok (eds). Lancaster, England, MTP Press, 1981, pp 351–356

    Google Scholar 

  291. Thistle JL, Hofmann AF, Ott BJ, Stephens DH: Chenotherapy for gallstone dissolution. I. Efficacy and safety. J Am Med Assoc 239:1041–1046, 1978

    Google Scholar 

  292. Thistle JL, LaRusso NF, Hofmann AF, Turcotte J, Carlson GL, Ott BJ: Differing effects of ursodeoxycholic or chenodeoxycholic acid on biliary cholesterol saturation and bile acid metabolism in man: A dose-response study. Dig Dis Sci 27:161–168, 1982

    PubMed  Google Scholar 

  293. Thistle JL, Ott BJ, Ellefson RD: Serum lipoprotein cholesterol changes during bile acid ingestion for gallstone dissolution. Gastroenterology 75:990, 1978 (abstract)

    Google Scholar 

  294. Thomas PJ, Hsia SL, Matschiner JT, Doisy EA Jr, Elliott WH, Thayer SA, Doisy EA: XIX. Metabolism of lithocholic acid-24-14C in the rat. J Biol Chem 239:102–105, 1964

    PubMed  Google Scholar 

  295. Thudichum JLW: A treatise on gallstones: their chemistry, pathology and treatment. London, John Churchill and Sons, 1863

    Google Scholar 

  296. Tint GS, Salen G, Colalillo A, Graber D, Verga D, Speck J, Shefer S: Ursodeoxycholic acid: a clinical trial of a safe and effective agent for dissolving cholesterol gallstones. Gastroenterol 80(part 2):1304, 1981 (abstract)

    Google Scholar 

  297. Tobiasson P, Fryden A, Tagesson C: Serum bile acids after test meals and oral load of chenodeoxycholic acid. Scand J Gastroenterol 16:763–767, 1981

    PubMed  Google Scholar 

  298. Töndury GD: Die Behandlung eines Syndroms von dyspeptischen Beschwerden mit Ursodeoxycholsäure. Praxis 70:969–973, 1981

    PubMed  Google Scholar 

  299. Toyoshima S, Fujita H, Sakurai T, Sato R, Kashima M: Reproduction studies of ursodeoxycholic acid in rats. (II) Teratogenicity study. Pharmacometrics 15:931–945, 1978

    Google Scholar 

  300. Toyoshima S, Fujita H, Sato R, Kashima M: Reproduction studies of ursodeoxycholic acid in rats. (4) Perinatal and postnatal study. Pharmacometrics 15:1141–1155, 1978

    Google Scholar 

  301. Toyoshima S, Fujita H, Sato R, Kashima M, Sato S: Reproduction studies of ursodeoxycholic acid in rats. (1) Fertility study. Pharmacometrics 15:923–930, 1978

    Google Scholar 

  302. Toyoshima S, Fujita H, Sato R, Kashima M, Sato S: Teratogenicity study of ursodeoxycholic acid in rabbits. Pharmacometrics 15:1133–1140, 1978

    Google Scholar 

  303. Trotman BW, Petrella E, Soloway RD, Sanchez H, Morris T, Miller WT: Evaluation of radiographic lucency or opaqueness of gallstones as a means of identifying cholesterol or pigment stones; correlation of radioopaqueness with mineral content. Gastroenterology 68:1563–1566, 1975

    PubMed  Google Scholar 

  304. Vernick LJ, Kuller LH: Cholecystectomy and right-sided colon cancer: An epidemiological study. Lancet 2:381–383: 1981

    PubMed  Google Scholar 

  305. Volpi C, Ciravegna G, Canepa A, De Conca, Celle G, Dodero M, Frigerio G: A cross-over double-blind trial comparing the effects of ursodeoxycholic acid (UDCA) and chenodeoxycholic acid (CDCA) on bowel habit in man. Curr Ther Res 26:225–229, 1979

    Google Scholar 

  306. Vuaridel D, Borel G-A, Bron B: Indication a la dissolution médicale de la lithiase biliaire et valeur de la détermination de l'index lithogene. Schweiz Med Wochenschr 110:877–879, 1980

    PubMed  Google Scholar 

  307. Walker S, Raedsch R, Götz R, Stiehl A, Czygan P, Kommerell B: Intestinale Resorption von konjugierter und nichtkonjugierter Urso- und Cheno-desoxycholsäure. Dtsch Ges Innere Med 193: April 1981 (abstract)

  308. Watari N, Torizawa K, Kanai M, Sato T, Yokoi K: Ultrastructural studies on the preventive effect of ursodeoxycholic acid in possible alloxan-induced pancreatic injury. J Clin Electr Microsc 9:69–81, 1976

    Google Scholar 

  309. Weiner IM, Lack L: Bile salt absorption; enterohepatic circulation.In Handbook of Physiology. Section 6: Alimentary Canal, CF Code (ed). Washington, DC, American Physiological Society, 1968, pp 1439–1455

    Google Scholar 

  310. Weis HJ, Holtermüller KH, Stiehl A, Czygan P: Clinical experience in bile composition in patients taking ursodeoxycholic acid for gallstone dissolution.In Biological Effects of Bile Acids, G Paumgartner, A Stiehl, W Gerok (eds). Lancaster, England, MTP Press, 1979, pp 90–102

    Google Scholar 

  311. Wheeler HO, King KK: Biliary excretion of lecithin and cholesterol in the dog. J Clin Invest 51:1337–1350, 1972

    PubMed  Google Scholar 

  312. Whiting MJ, Watts J MCK: Prediction of the bile acid composition of bile from serum bile acid analysis during gallstone dissolution therapy. Gastroenterology 78:220–225, 1980

    PubMed  Google Scholar 

  313. Williams G, Mathews L, Breuer NF, Murphy GM, Dowling RH: Effect of ursodeoxycholic acid (UDCA) on primary bile acid kinetics in gallstone patients. Clin Sci 58:15P, 1980 (abstract)

    PubMed  Google Scholar 

  314. Williams G, Maton PN, Meredith TJ, Murphy GM, Saxton HM, Dowling RH: Will “urso” replace “cheno” in the medical treatment of gallstones? A retrospective comparison and update of results with ursodeoxycholic acid therapy. (in press)

  315. Williams G, Murphy GM, Dowling RH: Effect of ursodeoxycholic acid (UDCA) on serum total and VLDL triglycerides in gallstone patients. Clin Sci 58:15P, 1980 (abstract)

    PubMed  Google Scholar 

  316. Williams G, Tenida N, Maton PN, Murphy GM, Dowling RH: The biliary cholesterol saturation index (SI) in ursodeoxycholic acid (UDCA)-rich bile: is the Carey correction necessary when predicting gallstone dissolution. 5th International Symposium on Bile Acids, Cortina d'Ampezzo, Italy, 1979, p 56 (abstract)

  317. Wolfson M, Miyai K, Javitt NB: Ursodeoxycholic acid toxicity in rabbits. Gastroenterology 73:A-57/1255, 1977 (abstract)

    Google Scholar 

  318. Wolpers C: The natural history of gallstone formation.In Interdisciplinary Trends in Surgery, Edizioni Minerva Medica, 1979

  319. Yamatake Y, Ishikawa S, Yanaura S: Effects of some bile acids on hepatic blood flow in dogs-with reference to biliary excretion. Jpn J Pharmacol 26:273–275, 1976

    PubMed  Google Scholar 

  320. Yanaura S, Ishikawa S: Choleretic properties of ursode-oxycholic acid and chenodeoxycholic acid in dogs. Jpn J Pharmacol 28:383–389, 1978

    PubMed  Google Scholar 

  321. Yousef IM, Tuchweber B, Vonk RJ, Masse D, Audet M, Roy CC: Lithocholate cholestasis—sulfated glycolithocholate-induced intrahepatic cholestasis in rats. Gastroenterology 80:233–241, 1981

    PubMed  Google Scholar 

  322. Zouboulis-Vafiadis I, Dumont M, Erlinger S: Conjugation is the rate-limiting step in the hepatic transport of ursode-oxycholic acid in the rat. Fourth International GTSAAD Symposium, Switzerland, Sept 8–10, 1981, p 10 (abstract)

  323. Zuin M, Dioguardi ML, Festorazzi S, Racca V, Podda M: Is the saturation index predictive for gallstone dissolution during treatment with ursodeoxycholic acid? Gastroenterology 78(part 2):1327, 1980 (abstract)

    Google Scholar 

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Supported in part by NIH grant AM 21506.

Part I of this article appeared inDigestive Diseases and Sciences, Volume 27 Number 8.

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Bachrach, W.H., Hofmann, A.F. Ursodeoxycholic acid in the treatment of cholesterol cholelithiasis part II. Digest Dis Sci 27, 833–856 (1982). https://doi.org/10.1007/BF01391378

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