Summary
Guinea pigs made hyperthyroid were found to have increased responsiveness to dopaminergic stimulation of the striatum as measured by the dosage of apomorphine necessary to elicit stereotyped behavior. A dosage of apomorphine which produced stereotyped behavior in only 3 out of 36 euthyroid guinea pigs induced this behavior in 18 out of 20 hyperthyroid guinea pigs. This observation suggests that striatal dopamine receptor site sensitivity is increased in hyperthyroidism and is consistent with the hypothesis that increased receptor site sensitivity plays a role in the pathophysiology of hyperthyroid chorea.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Andén, N.-E.: Pharmacological and anatomical implications of induced abnormal movements with L-dopa, in: L-Dopa and parkinsonism (Barbeau andMcDowell). Philadelphia: Davis. 1970.
Birkmayer, W.: Theα-methyl-p-tyrosine effect in extrapyramidal disorders. Wien. klin. Wschr.81, 10 (1969).
Carlsson, A.: Biochemical implications of dopa-induced actions on the central nervous system, with particular reference to abnormal movements, in: L-Dopa and parkinsonism (Barbeau andMcDowell). Philadelphia: Davis. 1970.
Cools, A. R., andJ. M. Van Rossum: Caudal dopamine and stereotyped behavior in cats. Arch. Int. Pharmacodyn. Ther.187, 163–173 (1970).
Diarman, W. R., R. Gordon, S. Spector, S. Sjoerdsma, andS. Udenfriend: Increased synthesis of catecholamines in the intact rat following administration of alpha adrenergic blocking agents. Mol. Pharm.4, 457–464 (1968).
Emlen, W., D. S. Segal, andA. T. Mandell: Thyroid state: effects on pre- and post synaptic central noradrenergic mechanisms. Science175, 79–82 (1972).
Ernst, A. M.: Mode of action of apomorphine and desamphetamine on gnawing compulsion in rats. Psychopharm.10, 316–323 (1967).
Ernst, A. M.: The role of biogenic amines in the extrapyramidal system. Acta. Physiol. Pharmacol. Neurol.15, 141–154 (1969).
Ernst, A. M., andP. G. Smelik: Site of action of dopamine and apomorphine on compulsive gnawing behavior in rats. Experientia (Basel)22, 837–838 (1966).
Fidler, S. M., R. A. O'Rourke, andH. A. Buchsbaum: Choreo-athetosis as a manifestation of thyrotoxicosis. Neurology21, 55–57 (1971).
Fog, R. L., A. Randrup, andH. Pakkenberg: Aminergic mechanisms in corpus striatum and amphetamine induced stereotyped behavior. Psychopharmacologia (Berlin)11, 179–183 (1967).
Fog, R. L., A. Randrup, andH. Pakkenberg: Neuroleptic action of quaternary chlorpromazine and related drugs injected into various brain areas in rats. Psychopharmacologia (Berlin)12, 428–432 (1968).
Heffron, W., andP. R. Eaton: Thyrotoxicosis presenting as choreoathetosis. Int. Med.73, 425–428 (1970).
Hornykiewicz, O.: Dopamine and brain function. Pharmacol. Rev.18, 925–964 (1966).
Klawans, H. L.: A pharmacologic analysis of Huntington's chorea. Europ. Neurol.4, 148–163 (1970).
Klawans, H. L.: The pharmacology of tardive dyskinesia. Amer. J. Psychiat.130, 82–87 (1972).
Klawans, H. L.: The pharmacology of extrapyramidal movement disorders. Basel: Karger. 1973.
Klawans, H. L., C. Goetz, andW. J. Weiner: Dopamine receptor site sensitivity in hyperthyroid and hypothyroid guinea pigs. Adv. Neuro. (1973, in press.)
Klawans, H. L., andR. Rubovits: An experimental model of tardive dyskinesia. J. Neural Transm.33, 235–246 (1972).
Klawans, H. L., andD. M. Shenker: Observations on the dopaminergic nature of hyperthyroid chorea. J. Neural Transm.33, 73–81 (1972).
Lipton, M. A., A. J. Prange, Jr., W. Diarman, andS. Udenfriend: Increased rate of norepinephrine biosynthesis in hypothyroid rats. Fed. Proc.27, 399 (1968).
Munkvad, I., H. Pakkenberg, andA. Randrup: Aminergic systems in basal ganglia associated with stereotyped hyperactive behavior and catalepsy. Brain Behav. Evol.1, 89–100 (1968).
Nyback, H., Borzeck, andG. Sedvall: Accumulation and disappearance of catecholamines formed from tyrosine-14-C in mouse brain; effect of some psychotropic drugs. Europ. J. Pharmacol.14, 395–403 (1968).
Nyback, H., andG. Sedvall: Regional accumulation of catecholamines formed from tyrosine-14-C in rat brain: effect of chlorpromazine. Europ. J. Pharmacol.5, 245–252 (1969).
Prange, A. J., J. L. Meek, andM. A. Lipton: Catecholamines: diminished rate of synthesis in rat brain and heart after thyoxine pretreatment. Life Science9, 901–907 (1970).
Randrup, A., andI. Munkvad: Role of catecholamines in the amphetamine excitatory response. Nature (London)211, 540 (1966).
Rubovits, R., andH. L. Klawans: Implications of amphetamine induced stereotyped behavior as a model for tarvide dyskinesias. Arch. Gen. Psych.27, 502–507 (1972).
Sattler, H.: Basedow's disease (trans.Ward, J. W., andJ. F. Marchand). New York: Grune and Stratton. 1952.
Syner, J. C., P. S. Fancher, andJ. W. Kemble: Chorea associated with hyperthyroidism. U.S. Armed Forces Med. J.5, 61–66 (1954).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Klawans, H.L., Goetz, C. & Weiner, W.J. Dopamine receptor site sensitivity in hyperthyroid guinea pigs: A possible model of hyperthyroid chorea. J. Neural Transmission 34, 187–193 (1973). https://doi.org/10.1007/BF01367508
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01367508