Abstract
Esophageal motor function was tested in 12 patients with a clinical diagnosis of diabetic gastroenteropathy by radionuclide transit (RT) studies. Other insulin-dependent diabetics with and without symptoms of peripheral neuropathy but with no symptoms of gastrointestinal disease were similarly studied. Eleven of the 12 patients with gastroenteropathy were found to have abnormal esophageal function, even though only five had esophageal symptoms. Half the diabetics with peripheral neuropathy symptoms, and a quarter of those with no symptoms had abnormal esophageal transit studies. No abnormalities were found in a group of asymptomatic volunteers studied in a similar manner. We conclude that esophageal dysfunction, often subclinical, is present in nearly all patients with suspected diabetic gastroenteropathy. Esophageal dysfunction correlates less well with peripheral neuropathy. This study implies that if a diabetic, presenting with diarrhea or nausea and vomiting, has normal esophageal transit, then a cause for these symptoms, other than diabetic gastroenteropathy, may exist.
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Feldman M, Corbett D, Ramsey E, Walsh J, Richardson C: Abnormal gastric function in longstanding insulin-dependent diabetic patients. Gastroenterology 77:12–17, 1979
Campbell I, Heading R, Tothill P, Buist T, Ewing D, Clarke B: Gastric emptying in diabetic autonomic neuropathy. Gut 18:462–467, 1977
Battle W, Snape W, Alavi A, Cohen S, Braunstein S: Colonic dysfunction in diabetes mellitus. Gastroenterology 79:1217–1221, 1980
Mandelstram P, Siegel C, Lieber A, Siegel M: The swallowing disorder in patients with diabetic neuropathy—gastroenteropathy. Gastroenterology 56:1–11, 1969
Silber W: Diabetes in esophageal dysfunction. Br Med J 3:688–690, 1969
Vela A, Balart L: Esophageal motor manifestations in diabetes mellitus. Am J Surg 119:21–26, 1970
Vix V: Esophageal motility in diabetes mellitus. Radiology 92:363–364, 1969
Mandelstram P, Lieber A: Esophageal dysfunction in diabetic neuropathy/gastropathy. J Am Med Assoc 201(8):88–92, 1967
Hollis J, Castell D, Braddam R: Esophageal function in diabetes mellitis and its relation to peripheral neuropathy. Gastroenterology 73:1098–1102, 1977
Russell C, Hill LD, Holmes E, Hull D, Pope C: Radionuclide transit—a sensitive test of esophageal dysfunction. Gastroenterology 75(2):1248, 1980
Russell C, Hill LD, Holmes E, Hull D, Gannan R, Pope C: Radionuclide transit: A sensitive screening test for esophageal dysfunction. Gastroenterology 80:887–892, 1981
Tolin R, Malmud L, Reilly J, Fisher R: Esophageal scintigraphy to quantitate esophageal transit. Gastroenterology 76:1402–1408, 1979
Horn S, Williamson J: Statistical methods for reliability and validity testing:An application to nominal group judgments in health care. Med Care 15:922–928, 1977
Cohen J: A coefficient of agreement for nominal scales. Educ Psychol Meas 20:37–46, 1960
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This work was supported by a grant from the Howard Wright family.
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Russell, C.O.H., Gannan, R., Coatsworth, J. et al. Relationship among esophageal dysfunction, diabetic gastroenteropathy, and peripheral neuropathy. Digest Dis Sci 28, 289–293 (1983). https://doi.org/10.1007/BF01324943
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DOI: https://doi.org/10.1007/BF01324943